What is Isotretinoin Pills Sotret®
Sotret® is manufactured by reputable Sun Pharmaceuticals. This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring.
Sotret® is an oral treatment for recalcitrant nodular acne (also called nodulocystic or cystic acne), acne conglobata, and acne fulminans. Sotret® capsules should be used in patients who failed to respond to safer acne treatments, including oral antibiotics. The active substance used in Sotret® is Isotretinoin, a first-generation anti-acne retinoid, a derivative of vitamin A.
Isotretinoin has strong comedolytic, keratolityc, sebostatic, and anti-inflammatory properties. It cures acne by suppressing skin oil secretion and follicular hyperkeratinization (overabundance of the dead epithelial cells in the pores). Isotretinoin reduces the size of sebaceous glands (microscopic organs producing skin oil) and exfoliates the dead skin cells from the pores. By these actions Isotretinoin indirectly reduces the amount of P. acnes in the skin.
When to use Isotretinoin Pills Sotret®
- Severe acne vulgaris (cystic, nodulocystic or recalcitrant nodular acne), characterized by red painful bumps, cysts, nodules with a diameter of 5 mm or greater, and painful lesions beneath the skin. It occurs if the skin produces too much sebum and pores get clogged, as the acne-causing bacteria P. acnes (Propionibacterium acnes) proliferate inside of a clogged pore.
- Acne conglobata, characterized by abscesses and draining sinus tracts in addition to nodulocystic acne symptoms.
- Acne fulminans, that develops after unsuccessful treatment of acne conglobata and is much harder to treat due to its unresponsiveness to the variety of medications.
How to use Isotretinoin Sotret® capsules
Read the Medication Guide provided by your doctor or supplied with the product before you start using isotretinoin and each time you get a refill. Read and sign a Patient Information/Informed Consent form before you start taking this medication. If you have any questions about isotretinoin, consult your doctor before taking the medication.
Swallow capsules whole. Do not crush or chew them. Isotretinoin is usually taken twice daily for 15-20 weeks, or as directed by your doctor. Directions for most generic forms of isotretinoin state that it should be taken with meals. Food helps increase absorption of this drug into your bloodstream. Take this drug with a full glass of water, and do not lie down for at least 10 minutes after taking it.
The dosage is based on your medical condition, weight, and response to treatment. Your acne may worsen during the first few days of taking this drug, and it may take up to 1-2 months before you notice the full benefit of this medication. If severe acne returns, the second course of treatment may be started after you have stopped taking the drug for 2 months. The manufacturer does not recommend long-term use of isotretinoin. Do not take more than the recommended dose.
Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication.
Side effects of Isotretinoin Sotret® capsules
Dry lips and mouth, minor swelling of the eyelids or lips, crusty skin, nosebleeds, upset stomach, or thinning of hair may occur. If any of these effects persist or worsen, tell your doctor. To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any of these unlikely but serious side effects: mental/mood changes (e.g., depression, aggressive or violent behavior, and in rare cases, thoughts of suicide), tingling feeling in the skin, back/joint/muscle pain, signs of infection (e.g., fever, persistent sore throat), painful swallowing, peeling skin on palms/soles.
Isotretinoin may rarely cause disease of the pancreas (pancreatitis) that may rarely be fatal. Stop taking this medication and tell your doctor right away if you develop: severe stomach pain, severe or persistent nausea/vomiting.
Stop taking this medication and tell your doctor right away if you develop these unlikely but very serious side effects: a severe headache, vision changes, ringing in the ears, hearing loss, chest pain, yellowing eyes/skin, dark urine, severe diarrhea, rectal bleeding.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Before taking isotretinoin, tell your doctor if you are allergic to it; or to vitamin A-related drugs (other retinoids such as tretinoin); or if you have any other allergies. This product may contain inactive ingredients (such as soybean, parabens), which can cause allergic reactions or other problems. Some people who are allergic to peanuts may also be allergic to soy.