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A common autoimmune skin disorder that results in partial loss of skin pigmentation, ie white patches of skin is named vitiligo. MBEH or monobenzone is the most commonly used depigmenting agent used in vitiligo. It is the only topical depigmentation treatment ingredient for extensive vitiligo that has been approved by the FDA.
Monobenzone unlike hydroquinone, almost always causes irreversible depigmentation, as it results in the death of melanocytes (the cells that make skin pigment or melanin). Depigmentation therapy refers to medical treatments that remove skin pigmentation causing contact leukoderma. Depigmentation therapy with skin depigmentation treatment products is used in someone that has widespread, but incomplete, vitiligo on the face and/or other sites, in an attempt to improve their appearance.