What Is Thyroid Disorder

What Is Thyroid Disorder

Thyroid disease is a common problem that can cause symptoms because of over- or under-function of the thyroid gland. The thyroid gland is an essential organ for producing thyroid hormones, which maintain are body metabolism. The thyroid gland is located in the front of the neck below the Adam’s apple. Thyroid disease can also sometimes lead to enlargement of the thyroid gland in the neck, which can cause symptoms that are directly related to the increase in size of the organ (such as difficulty swallowing and discomfort in front of the neck). Thyroid Supplements are widely used to support people who suffering from over- or under-function of the thyroid glands.

Symptoms of Thyroid Problems

Just as the types of thyroid conditions can vary, so can the symptoms of thyroid problems. Here are listed ten common symptoms of thyroid disease:

  • Nervousness and tremor: These symptoms, along with agitation, can signal an overfunction of the thyroid gland (hyperthyroidism).
  • Mental fogginess and poor concentration: Mental functioning can be affected in both hyperthyroidism (elevated levels of thyroid hormone) and hypothyroidism (too low levels of thyroid hormones). While sluggishness and depressed mood are often associated with hypothyroidism, hyperthyroidism can also lead to a reduced capacity for concentration.
  • Menstrual changes: Hypothyroidism is sometimes associated with excessive or prolonged menstrual bleeding, while hyperthyroidism can be characterized by scanty or reduced menstrual flow.
  • Feeling bloated: Fluid retention is often a sign of an underactive thyroid gland.
  • Racing heartbeat: An increased heart rate (tachycardia) and palpitations can be symptoms of hyperthyroidism.
  • Aches and pains: Muscle aches and pain can accompany different types of thyroid problems.
  • Weight gain: A modest amount of weight gain often accompanies conditions in which thyroid gland activity is lower than normal.
  • High cholesterol levels: An increase in blood cholesterol levels can occur in individuals with hypothyroidism.
  • Heat intolerance: People with an overactive thyroid gland often complain of intolerance to higher temperatures.
  • Feeling cold: Conversely, those with an underfunctioning thyroid may feel constantly cold.

It is important to remember that none of these symptoms is absolutely specific for thyroid disease. All of them may be caused by a number of different conditions and normal states. Your health care professional can order laboratory tests to evaluate the function of your thyroid gland if you have troubling symptoms.

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Retin-A VS Retin-A MICRO®

Retin-A VS Retin-A MICRO®

Everyone should know that prior to the development of Retin-A in the 1970’s, by Dr.Albert Kligman and Dr.James Fulton, dermatologists basically relied upon oral Vitamin A to help treat acne, and just a few topical treatments helped with signs of photoaging.

Then Retin-A Cream was developed.  Although it was originally used as an acne treatment product, Retin-A has numerous uses now, such as:

  • Treating signs of aging
  • Deeply exfoliating the skin
  • Acting as a keratolytic agent (an agent that removes a plug out of a hair follicle or sweat gland).

After that, different delivery systems of tretinoin were developed, including the following:



Here are the most important things you need to know about Retin-A and the different forms of tretinoin.

1. Retin-A Micro is better for skin and much innovative than Retin-A.

Retin-A Micro is just a technologically evolutioned Retin-A. Retin-A Micro has the sustained Microsponge® systems technology enables the retinoid to be active in your skin for a longer time and absorb faster and deeper in skin cells. The Retin-A Micro Microsponge® system prevents the accumulation of excessive tretinoin within the surface layers of the skin. Each Microsponge® is less than one-thousandth of an inch of diameter, holding a small amount of tretinoin in reserve and introducing only small amounts of tretinoin to the skin over time during prolonged period.

The progressive Microsponge® delivery technology is the reason why Retin-A Micro has higher efficacy and lower irritation rates than simle Retin-A gel or cream. Remember, your skin never gets more vitamin A than it can handle at one time. Retin-A Micro is superior for those with oily and sensitive skin types, due to there being more shine reduction and less irritation potential than with traditional Retin-A.

There is one smaill downside – Retin-A Micro is significantly more expensive than Retin-A, although the price may vary.


2. If your skin is rough, you still may prefer creamy emollient tretinoin options for dry and rough skin such as – Retin-A 0.025% & Retin-A 0.05% and its analogs/generics such as Tretoin 0.05%, Retino-A 0.025%, Retino-A 0.05%, Tretin 0.025%, Tretin 0.05%. They are all has the same active ingredients as Retin-A and Retin-A Micro: (tretinoin at 0.05% or 0.025% concentration).

Only Renova is FDA-approved for the treatment of skin surface roughness following UV exposure, including fine facial wrinkles and brown spots. But as we can see all this mentioned creams has the same composition so you can choose whichever you like and achieve the same or better results with all of this analogs/generics and original Retin-A cream.

The reason why plain Retin-A cream is significantly better than Retin-A Micro gel/cream for treating skin aging is due to its emollient system, which prevents irritation for dry and rough skin types (proved by biomedical and Life Sciences). Retin-A softens and soothes the skin once it is absorbed, so users typically have much better compliance, sticking with it far longer than Retin-A Micro.

Since your skin only turns over once every three to four weeks as an adult, it takes this long to see reductions in fine facial wrinkles and brown spots. Since a lot of people have given up on  Retin-A Micro in this time, it makes emollients tretinoin creams the better choice for skin aging.


3. Adaferin has NOT the same active ingredient as Retin-A, Retin-A Micro or Tretoin. It may be better for acne tretment purposes.
People often think that all retinoids are the same, but in fact they are not. Adaferin is a form of tretinoin called adapalene at 0.1%. Tazorac or Tazret is a form of vitamin A called tazarotene at 0.1% or tazarotene at 0.05%.

Adaferin or Differin contains adapalene, a derivative of naphthoic acid. Adaferin or Differin possesses similar biological properties of tretinoin, but has higher solubility in fats and oils, and increased photostability (i.e., stability in light).

Adaferin or Differin is also a lot more targeted than Retin-A or Retin-A Micro. Adaferin or Differin only binds to specific receptors within the skin, RAR-β and RAR-γ, whereas Retin-A or Retin-A Micro binds to a multitude of proteins.

What this means for practical purposes is that adaferin/differin is great for cutting through oil and treating acne. At 12 weeks, the combination has been shown to significantly reduce total, inflammatory, and non-inflammatory acne lesions. It has also been shown to have fewer side effects than tretinoin.


4. Tazret / Tazorac also does not have the same form of vitamin A as Retin-A or Retin-A Micro. It may be better for psoriasis.
Tazret / Tazorac contains a form of vitamin A known as tazarotene at 0.1% or tazarotene at 0.05%.

Tazorotene is the first retinoid formulated specifically for psoriasis. Like Adaferin and Differin, Tazorac only binds to specific receptors in the skin, RAR-β and RAR-γ.

But if you’re considering Tazorac for treating fine lines, wrinkles, and other signs of UV damage and aging, you may want to reconsider. There are a lot of evidences nowadays that tazarotene benefit patients with moderate photodamage on the face.


5. Retinol is a non-prescription formula and about 20 times less potent than tretinoin (Retin-A, Retin-A Micro, Adaferin and Tazret).

Retinol has incredible efficacy but is technically still a cosmetic rather than a cosmeceutical or professional dermatologis solution. This is because retinol must be activated within the skin before it can do anything: retinol must first be converted to retinaldehyde, and then a compound called all-trans retinoic acid within the skin in order to be effective.

In general, retinol is considered to be about 20 times less potent than retinoic acid, ounce for ounce. So a 0.025% tretinoin is like a 0.50% retinol. A 0.050% tretinoin is like a 1.0% retinol.

Although retinol needs to be present in higher quantities than tretinoin in order to be effective, patients typically experience lower levels of irritation when using retinol products. This may be due to the time it takes for retinol to convert to all-trans retinoic acid within the skin.


6. Retinyl palmitate is even weaker than retinol.
Retinyl palmitate is a combination of pure retinol and palmitic acid  – a substance typically used in cosmetics as a cleansing agent.

Retinyl palmitate must be broken down into retinol and palmitic acid, and then the retinol must still be converted to retinaldehyde and then all-trans retinoic acid within the skin in order to be effective.

It is true that retinyl palmitate present in sufficiently high concentrations can have efficacy similar to that of retinol. But have you ever seen a skin care product say “5.0% retinyl palmitate?” No. Manufacturers of retinyl palmitate don’t dare suggest the concentration of retinyl palmitate, because it leads to questions they don’t want to answer. They know it doesn’t do much, if anything.

You’ll sometimes see retinyl palmitate added towards the bottom of ingredient lists in products. If they’re great products aside from the retinyl palmitate, I’ll still advocate for them. Never buy a skin care product with retinyl palmitate less than  concentration of 5% or higher, because they are all super weak.

Dermatologist are always advised Retin-A and Retin-A Micro for skin aging problems, but try to rethink all you read now and consider the following: Retin-A Micro has better efficacy than Retin-A cream; Retin-A & Tretoin creams has been shown to have better results for treating signs of sun damage than Retin-A Micro, with typical use; Adaferine or adapalene may be better for people with acne who also want to improve their skin; Tazret or tazarotene may be better for people with psoriasis who also want to improve their skin; 0.025% tretinoin is similar to 0.50% retinol; 0.050% tretinoin is similar to 1.00% retinol; Retinol is far more effective than retinyl palmitate.

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Everything you need to know about Retinol & Retinoids

Everything you need to know about Retinol & Retinoids

Yes and no. Prescription strength formulas contain retinoic acid, the magic ingredient that fights visible aging; nonprescription alternatives need to be converted into retinoic acid by the skin at the cellular level. “In off-the-shelf formulas, the ingredient called retinol is the only derivative of vitamin A worth using,” says an associate professor of dermatology at the University of Michigan Medical School. “There’s a lot of literature showing that while retinol is more gentle than retinoic acid, biochemically it does exactly the same thing – it may just take a lot longer to see results.” The same can’t be said for the derivatives called pro-retinols (a.k.a. retinyl palmitate, retinyl acetate, and retinyl linoleate), which are the most gentle and weaker, too. Retin-A Cream is one of the strongest retinoic acid component cream available. Other OTC analogs like ROC Night cream with Retinol are weak and not contain pure all-trans-retinoic acids but only weaker formulas for general purposes.

Retinoic acid swept away dead skin cells and it means exfoliating. “There’s often peeling and redness, but that’s a side effect of the irritation – not a true and even exfoliation, like the one you get from an ingredient like glycolic acid or other AHA acids,” says dermathologists. The peeling is generally not why people start looking better. In fact, it’s why most people give up using retinoic acids or retinols. Retinoids work at a much more profound level by affecting gene expression and causing enhanced skin collagen production, skin smoothing, and evening out of pigmentation.

This is one of the biggest myths out there, it’s true that retinoids break down in sunlight, which is why they are bottled in opaque packaging and are still best worn at night – to make sure they aren’t rendered inactive. However, they do not make the skin more prone to sunburn. This misconception came about because in some early studies, people described putting on a retinoid, walking into the sun, and immediately burning. But that redness is likely related to heat exposure. Clinical studies have shown pretty definitively that retinoids do not lower the minimal erythemal dos of human skin, which is the amount of UV light you can take before the skin burns. When we talk about prescription strength Retinoids starting from 0.025% concentration you should always use UV Sunscreens no matter you go under the sun or staying at home, its obligatory!

The instructions on the box often recommend waiting until your face is completely dry before applying a retinoid, but there’s no evidence in the scientific literature that shows damp or wet skin exacerbates sensitivity. Applying a retinoid to damp skin doesn’t maximize its potency, either. We would recommend applying retinoic acid creams on completely dry skin.

Many over-the-counter formulas claim you’ll see results within weeks, but in over-the-counter world it takes an average of 12 weeks for retinoic acid to produce noticeable changes in the skin – so stick with it for at least that long to see the benefits. By the way prescription strength retinoic acids like Retin-A starting acting same week, and dramatic improvements may seen within 1-2 weeks from start of usage.

The answer is No. OTC Retinoids are the weakest, but medical strengths retinoic acids are very potent starting from 0.025% concentration. Sensitive skin are often code for a low concentration of active ingredients. However, dermatologists still recommend them because these lower concentrations (and soothing supplemental ingredients) make them the perfect gateway retinoid. Once a user with sensitive skin has tolerated a tube of that, over a period of several weeks, or a weaker Retin-A 0.025% Cream we can then graduate to a stronger retinoid knowing the skin cells are now better adapted to handle it.

Irritation that flares up after adding vitamin A cream to your regimen is all part of the process. We’ve seen clinically that after two or three weeks, the skin cells adapt to the retinoic acid and begin to tolerate the ingredient and irritation caused by it. The caveat: We’re talking about reasonably flushed, drier-than-usual, lightly peeling skin. If the discomfort is prolonged or very uncomfortable, use it once a week or switch to a weaker formula.

A change in climate won’t suddenly make your skin react to a retinoid you were tolerating a few days earlier at home. Once skin cells have adapted to the strength of the retinoid you’re applying, any irritation (called retinoid dermatitis) generally stops. It’s unlikely to flare up again until you switch to something stronger. Still, if you’re jumping on a long-haul flight or going skiing, it’s a good idea to layer a heavier moisturizer over your retinoid to avoid dryness, which makes skin more susceptible to irritation in general.

We’re still processing the fact that retinoids don’t increase your risk of sunburn, too. But get this: Combining retinoids with island hopping may even be a good thing. They not only boost collagen production, but may also have the potential to stop photoaging before it starts. They’ve been shown to prevent the rise of collagenase – the enzyme that breaks down collagen—after UV exposure. But please remember to use strong Sunscreens when on vacation!

Not only can you, you really should – that’s where most of the damage shows up. “Studies have shown that people who apply retinoids right up to the eyes get the best results. And if you get it in your eye? It may sting a little, but it won’t do any harm, and the skin there is no more likely to get red or flaky than anywhere else on the face. But please don’t use strong Retinoids starting from 0.04% concentration under your eyes, they are really strong for under eye sensitive skin!

Several clinical studies have shown that prescription retinoids will significantly improve skin for over a year, when used 2-3 months, and Johnson & Johnson recently completed a trial demonstrating that over-the-counter retinol smooths wrinkles and fades blotches over 12 months, too, not so significantly. OK, so what are you supposed to do after the year is up? The answer isn’t to rush off and embrace a new ingredient (peptides, anyone?). Your skin may just be ready for a stronger prescription retinoids.

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