WHAT IS DERIVA CMS ADAPALENE 0.1% + CLINDAMYCIN 1% GEL
Deriva CMS Gel is made by popular Glenmark Pharmaceuticals and containing micronized Adapalene 0.1% in Microspheres and Clindamycin 1.0% in Microspheres. Adapalene 0.1% is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, it works by stopping pimples from forming under the surface of the skin, and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Vitamin A derivative Adapalene works to correct the irregular skin cell shedding that’s irritating your skin and clogging your pores. Clindamycin Phosphate 1% component in Deriva CMS Gel works by preventing bad bacteria from producing proteins that are essential to them. Without these proteins, the bad bacteria cannot grow, replicate, and increase in numbers which will allow the immune system to treat the infection. Clindamycin 1% component is mainly prescribed to treat serious infections caused by bacteria such as acne, pimples, and various bacterial skin infections.
Deriva CMS Adapalene 0.1% & Clindamycin 1% Gel is currently marketed by Galderma under the brand names Differin and “Epiduo® Gel” – this acne treatment gel which is new to the market also contains benzoyl peroxide component. Deriva CMS Gel has the most technologically advanced time-release formula with a micro-gel base for deeper skin penetration absorbs faster with a special Microsponge molecular delivery system called – Microspheres. Deriva CMS Gel has a regenerating effect, removes acne without scarring, reduces the oiliness of the skin; eliminates and prevents black spots, good consistency, easily absorbed, pretty bland, rarely causes side effects, FDA – approved product.
Not all Adapalene & Clindamycin gels are the Microspheres formula. The regular Adapalene Differin gel is not a time-release formula, and the gel itself contains a high amount of denatured alcohol. Deriva CMS Adapalene 0.1% Clindamycin 1% Microspheres formula does not contain as much denatured alcohol and is an opaque color. The difference is that Deriva CMS Adapalene 0.1% + Clindamycin 1% Microspheres uses a special delivery system called Microsponge, which is composed of tiny, sphere-shaped particles with a porous surface. The porous surface allows for a sustained flow of the Adapalene & Clindamycin out of the sphere and is what makes Deriva CMS Adapalene 0.1% & Clindamycin 1% Gel Microspheres a time-release product. It’s worth noting that the spheres are so small that you cannot see or feel them in the product.
Deriva CMS gel is a combination of topical-antibiotic-plus-retinoid treatment of inflammatory acne using adapalene 0.1 percent gel (Differin) with clindamycin 1 percent lotion offers better efficacy and safety compared with clindamycin 1 percent lotion alone, according to the world researches.
The combination adapalene/clindamycin and clindamycin monotherapy regimens were compared in a 12-week, multicenter, randomized, investigator-masked, vehicle-controlled trial enrolling 249 subjects. The patients applied adapalene or its vehicle gel each evening. They applied clindamycin twice daily, once in the morning, and again two minutes after evening application of the topical retinoid or vehicle control.
Efficacy and safety were assessed at follow-up visits conducted after weeks two, four, eight, and 12, and the analyses showed the combination regimen was associated with a significantly faster onset of effect and greater overall efficacy in clearing inflammatory and non-inflammatory lesions. Significant differences favoring adapalene plus clindamycin were seen as early as week two in analyses of the percent reduction in both total and non-inflammatory lesion counts. Those benefits were maintained throughout the study. Beginning at the week eight visit, there was a significant advantage of the combination treatment with regard to the percent reduction in inflammatory lesions.
Safety, evaluated by investigator ratings of the severity of erythema, scaling, dryness, and stinging and burning, also showed a significant benefit of the combination treatment. Patients using adapalene plus clindamycin experienced significantly less erythema than their counterparts using the topical antibiotic plus vehicle gel. Other than that, there were no significant differences in local reactions or other reported adverse effects between the investigational groups.
Deriva CMS with Adapalene 0.1% & Clindamycin 1% Gel can also be used as a wrinkle prevention solution.