WHAT IS ACNETOR AD ADAPALENE 0.1% + CLINDAMYCIN 1% GEL
Acnetor AD Gel is made by Torrent Pharmaceuticals and containing Adapalene 0.1% and Clindamycin 1.0% components.
Adapalene 0.1% is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, it works by stopping pimples from forming under the surface of the skin, and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Vitamin A derivative Adapalene 0.1% works to correct the irregular skin cell shedding that’s irritating your skin and clogging your pores. Unlike the retinoid tretinoin (Retin-A), adapalene has also been shown to retain its efficacy when applied at the same time as benzoyl peroxide due to its more stable chemical structure. Unlike tretinoin, adapalene inhibits keratinocyte differentiation. This inhibition of keratinocyte differentiation and proliferation is responsible for adapalene’s comedolytic effect. It has both exfoliating and anti-inflammatory effects. In an in vivo study, adapalene’s ability to reduce comedo formation was demonstrated by a 50–60% reduction in comedo counts compared with vehicle.
Acnetor AD Gel same as Differin Gel contains adapalene, a type of retinoid. Topical retinoids play a crucial role in the treatment of acne. Retinoids have vitamin A activity which helps regulate cell turnover to make sure your skin goes through the right process, creating a healthier environment for skin. Regulating cell turnover helps to keep the pores from clogging and target acne before it even starts. Don’t think of Acnetor AD Gel as a spot treatment only to be used when acne rears its ugly head. In fact, if used daily, Acnetor AD Gel stops new acne from forming, resulting in improved skin tone and texture.
Retinization is the adjustment period in which the skin becomes acclimated with the retinoid adapalene. During this time skin may become irritated, resulting in dryness, scaling, redness and burning/stinging. Irritation usually lessens after four weeks of continued, once-daily use. It’s also important to note that some never experience retinization. This simply means Acnetor AD Gel is still working under the surface of the skin without causing any irritation. Okdermo Skin Care Store Moisturizers works to help relieve the dryness associated with retinization.
In the United States, Adapalene is available under the brand name Differin by Galderma. Adapalene is also available combined with benzoyl peroxide under the brand name Epiduo. Adapalene is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin. It is mostly available in 0.1% gel form.
Clindamycin 1% anti-inflammatory component in Acnetor Gel works by preventing bad bacteria from producing proteins that are essential to them. Without these proteins the bad bacteria cannot grow, replicate and increase in numbers which will allow the immune system to treat the infection. Clindamycin 1% component is mainly prescribed to treat serious infections caused by bacteria such as acne, pimples and various bacterial skin infections. Acnetor AD Adapalene 0.1% & Clindamycin 1% Gel is currently marketed by Galderma under the brand names Differin and “Epiduo® Gel” – this acne treatment gel which is new to the market also contains benzoyl peroxide component, you can also buy benzoyl peroxide separately if you would like.
BENEFITS OF ACNETOR AD ADAPALENE 0.1% + CLINDAMYCIN 1% GEL
Acnetor AD gel is a combination of topical-antibiotic-plus-retinoid treatment of inflammatory acne using adapalene 0.1 percent gel (Differin) with clindamycin 1 percent lotion offers better efficacy and safety compared with clindamycin 1 percent lotion alone, according to the world researches.
The combination adapalene/clindamycin and clindamycin monotherapy regimens were compared in a 12-week, multicenter, randomized, investigator-masked, vehicle-controlled trial enrolling 249 subjects. The patients applied adapalene or its vehicle gel each evening. They applied clindamycin twice daily, once in the morning and again two minutes after evening application of the topical retinoid or vehicle control.
Efficacy and safety were assessed at follow-up visits conducted after weeks two, four, eight, and 12, and the analyses showed the combination regimen was associated with a significantly faster onset of effect, and greater overall efficacy in clearing inflammatory and non-inflammatory lesions. Significant differences favoring adapalene plus clindamycin were seen as early as week two in analyses of percent reduction in both total and non-inflammatory lesion counts. Those benefits were maintained throughout the study. Beginning at the week eight visit, there was a significant advantage of the combination treatment with regard to percent reduction in inflammatory lesions.
Safety, evaluated by investigator ratings of the severity of erythema, scaling, dryness, and stinging and burning, also showed a significant benefit of the combination treatment. Patients using adapalene plus clindamycin experienced significantly less erythema than their counterparts using the topical antibiotic plus vehicle gel. Other than that, there were no significant differences in local reactions or other reported adverse effects between the investigational groups.
Acnetor AD with Adapalene 0.1% & Clindamycin 1% Gel can also be used as an wrinkle prevention solution.
HOW TO USE ACNETOR AD ADAPALENE 0.1% + CLINDAMYCIN 1% GEL
Acnetor AD Gel should be used only once daily and integrated as an important step into your morning or evening skincare routine. Try to apply the product at the same time each day. For best results, first wash skin with a mild (non-irritating), non-drying cleanser; apply a thin layer of Acnetor AD Gel to clean, dry skin (full face); and follow treatment with a moisturizer. If Acnetor AD Gel is used during the day, allow it to dry before applying sunscreen. Acnetor AD Gel should not be used more than once a day. Applying more than directed will not provide faster or better results.