Tretin® Emollient Cream 30g/1.05oz

Tretinoin USP 0.025%-0.05%
(62 customer reviews)

USD $31.00USD $33.00

✓ Mild and moderate strengths available in creamy base

✓ Chemical skin exfoliator peel cream

✓ Retinoic acid cream suitable for acne/wrinkle treatment

✓ Extremely effective in combating signs of aging

✓ Acne and after-acne treatment solution

✓ Works by increasing the skin cell turnover rate and helps gently exfoliate the skin

Tretin cream in a big 30g tube with tretinoin (aka Yellow peel or Retinol peel) concentration equal to 0.025% or 0.05% is made by reputable H&H Company. Tretinoin widely used as a chemical peel component for skin peeling procedures. Main ingredient is a retinoic acid (Vitamin A or  stable strong medical grade Retinol).

Retinoic acid peel effectively cleanse the skin, regenerate skin cells, has anti-inflammatory effects, makes skin glow, improves skin texture and structure, provides a lifting effect. Use tretinoin cream only when prescribed by your dermatologist.

Tretinoin generally used to treat acne, keeping skin pores clear. When used correctly, Tretin cream does amazing things for skin.  Tretinoin has proven itself to reduce, reverse, and prevent wrinkles, it’s never too late to start using it. Brand names – Atralin, Avita, Refissa, Renova, Retin-A, Tretin-X, Rejuva-A, Stieva-A cream, Vitamin A Acid.

Title Range Discount
Items: 2 - 3 4%
Items: 4 - 6 8%
Items: 7 - 11 14%
Items: 12 + 20%


What is Tretin® tretinoin 0.025-0.05 retinol cream

Tretin tretinoin cream is used to treat fine wrinkles, dark spots, or rough skin on the face caused by damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and by slowing down the way the body removes skin cells that may have been harmed by the sun. Tretinoin cream works best when used within a skin care program that includes protecting the treated skin from the sun. Tretin is available without prescription in okdermo skin care store.

All-trans-retinoic acid, aka tretinoin is an active form of retinol (vitamin A). In nature, it can be found both in vegetable substances and in animal products. It is capable of making bonds with nuclear receptors and initiating a cellular response with their help. It is worth mentioning that almost all cells in a body are sensitive to tretinoin. To prevent it accumulation in tissues, which in many cases may lead to various side effects, only small amount of product should be used on particular areas only. The result of Tretin cream application is active exfoliation, which leads to epidermis renewal at the cellular level, the quality of the extracellular matrix of the dermis is also considerably improved.

Retinoic acid is a chemical peel and belongs to skin treatments with a short recovery period. Retinoids (synthesized equivalents of vitamin A) regulate the processes of differentiation, proliferation, and intercellular communication. When retinoids get into a cell, they make a bond with nuclear sensors. As a result, particular sections of the cell genome are activated or decelerated.

Since the main effect of retinoids on cells is produced through nuclear sensors (through nuclear receptors and specific molecular activation mechanisms), they can be included in the same category as thyroid and steroids. The main advantages of this treatment are minimal skin damage, a brief recovery period and a low probability of complications.

  • Tretin cream (Retin-A) is clearly a powerful skin care treatment, but there are tricks for using it to get the greatest benefits.
  • Always apply it to your skin at bedtime. Never use it during the day and totally avoid the sunlight.
  • Never layer tretinoin with benzoyl peroxide and ideally don’t apply it when you also have acid products on your skin like vitamin C, glycolic acid or salicylic acid.
  • Always wait at least 15-30 minutes after cleansing and applying any other skin care products to your skin before you apply tretinoin cream.

Benefits of using tretinoin 0.025-0.05 retinoic acid peel

  • Tretinoin helps to lighten the skin and prevent age spots by the way of exfoliating and deep chemical penetration capabilities.
  • Tretinoin builds collagen to thicken and increase the structural strength of treated skin.
  • Tretinoin helps to decrease a person’s risk of developing skin cancer. (This should be reason enough!)
  • Skin just looks better and younger when use tretinoin.

Despite the many benefits of Tretin cream therapy to prevent wrinkles and other issues of aging skin, it can result in some issues if it’s not used correctly. For instance, when starting tretinoin therapy, you need to begin with “pearl-sized” portions for the face, neck, and chest. It is important to begin using it gradually to allow your skin to adjust. Its recommended to use it twice a week (every third night) for the first couple of months. During this time, understand that a little scaliness and irritation is normal at first, but if the treated skin becomes really sensitive, back off the tretinoin for a bit. Let your skin return to normal before you begin the treatment again. As your skin adjusts, slowly try to increase to using it every night.

Always consult to your dermatologist prior start using any tretinoin products topically.

When to use Tretin® tretinoin 0.025-0.05 retinoic acid peel

  • Lack of collagen production;
  • Disruption of skin’s natural moisture balance;
  • Mimic wrinkles;
  • Loss of skin elasticity and strength;
  • Need for skin whitening;
  • Excessive pigmentation caused by solar radiation;
  • Skin aging and photoaging;
  • Acne and problematic skin;
  • Acne scars treatment;
  • Hyperpigmentation;
  • Hyperkeratosis.

Contraindications for Tretin® tretinoin 0.025-0.05 retinol cream

  • Various allergies – indicate the probability of severe skin reaction to the treatment, also increased with the use of retinoids that makes skin more reactive;
  • Atopic skin, eczema, seborrheic dermatitis etc. – indicate skin hypersensitivity (reactivity);
  • Viral infections – under the influence of retinoids and acids, can cause herpes lesions in patients with a history of herpes;
  • Warts – can cause further viral shedding from a wart;
  • Photosensitivity – high skin sensitivity to solar or other types of UV radiation;
  • Compatibility with pharmaceutical products – those who have taken roaccutane should wait at least half a year before getting a retinoic acid peel;
  • Liver diseases, including previous hepatitis infections;
  • Pregnancy or pregnancy planning within a year, as well as lactation, for retinoids are embryotoxic, do not use Tretin cream if you pregnant or planning to become.

Related resources/references:

  1. Retin-A cream User Guide
  2. Retin-A vs Retin-A Micro®
  3. Tretinoin cream for wrinkles
  4. Retin-A tretinoin: Cream vs Gel
  5. The difference between Retin-A and Tretinoin
  6. How to minimize irritation/redness with Retin-A
  7. Everything you need to know about Retinol & Retinoids
  8. User reviews for Retin-A
  9. Retin-A (Topical)
  10. Retin-A (Gel)
  11. Tretinoin (Topical)
  12. Acne treatment with tretinoin
  13. Retin-A side effects


Hegde & Hegde Pharma

Hegde & Hegde Pharmaceutica LLP is a professionally managed speciality Dermatological company, promoted by Dr. B. V. Hegde, MD; MS; MACG and Dr. Hemanth Hegde, MBBS in the year 1989. Dr. B V HEGDE passed his MS (Medicine) 1st Class with Honours from the University of Southern California, Graduate School of Medicine (Los Angeles) and has been now associated with the Pharmaceutical sector for more than 50 years. During these years he was associated with Roche Pharma for 6 years, Ethnor Limited for 20 years as Chief Executive and as Executive Director and Vice President Johnson & Johnson. He is credited with making Ethnor an integrated multi-crore Company. Post-retirement he set up Hegde & Hegde Pharmaceutica along with his son Dr. Hemanth Hegde. Dr. B. V. Hegde and Dr. Hemanth Hegde share a vision – to build Hegde & Hegde Pharmaceutica into a dermatological giant, by providing and ethically promoting – high-quality products and services to the field of Dermatology. A vision they are transforming to reality, with a high degree of professionalism. Over the years, Hegde & Hegde Pharmaceutica a dedicated speciality product company marketing a high-quality range of Dermatological products has grown to a multi-crore, multi-product specialized Dermatological company having a wide network of Stockists and Retailers throughout India and neighboring countries. Our formulations have been developed after extensive market research and have a decisive edge over similar competitive products. The product range covers a wide spectrum of dermatological indications and includes a range of Anti-Fungal, Anti-Bacterial, Anti-Acne, and Anti-Dandruff products as well as a superior, widely tested sunscreen – SUNBAN and DERMADEW range of moisturizers and soap. Our products have been extremely well accepted by Dermatologists and their patients throughout India and neighboring countries.

Additional information


Mild 0.025%, Moderate 0.05%


  • Tretinoin USP 0.025 or 0.05  w/w
  • Preservative Sorbic acid IP 0.20% w/w
  • Preservative Butylated Hydroxytoluene IP 0.10% w/w
  • Cream base q.s.
  • Adequate average added

Apply as directed by your dermatologist.

62 reviews for Tretin® Emollient Cream 30g/1.05oz

  1. Enrique

    No regrets, work as it should, and the price is awesome for 30g tube!

  2. Lloyd Carter

    I have been using tretinoin since my early 20’s when I began to suffer from cystic acne, and I have never really stopped using it – over 25 years. YOU MUST WEAR SUNBLOCK if you use this. I always put on sunblock, always. I wish I had been this vigilant when I was in my twenties – would have saved me some money on laser treatments.

  3. Angelo Erickson

    30g of pure tretinoin, it is quite creamy, satisfied. Shipping took forever, dislike

  4. Darin Owen

    30g tube and great price from okdermo, buying only this brand, several tubes at once, not so popular but works for me!

  5. Jake Fleming

    This stuff is such a pain to use! After you use it your skin peels for days. I originally bought if for clogged pores that nothing would help with and it didn’t work as amazingly as I had hoped. So for a few months I used it for an acne spot treatment, which it worked amazing for. But the last couple months I’ve been been using it for pitted scaring and amazing isn’t even a big enough word! For the last 20 years I have had pitted scaring (on my nose of all places) and even though I’ve mastered the art of covering them up (spackling miracle-blur) it has caused me so much anxiety and caused me to feel so self-counciousness. I have 3 holes right down the middle of my nose for everyone to wonder what the hell happened (acne happened, don’t pick your acne) and I was starting to lose hope in fixing them (ps don’t dermaroll your nose). I use 0.05% 1 or 2 times a week, or when ever I have time to look peely-freaky for the next couple of days and I pretty much shed an entire layer of skin. A few months of this and the scars are a third of what they were! SO amazed! They have become not that big of a deal at all. Oh and I forgot to mention I’ve never been to the dermatologist but heard people online highly recommending this shop under the name “okdermo”, I ordered, it took 3 weeks to get from okdermo to Canada. I’m not sure what people usually pay but this seemed very worth it to not have to pay to see a dermatologist. Overall, totally worth it 🙂

  6. Tommie Carlson

    u wun be disappointed

  7. Derek K

    This stuff is the spawn of Satan, burn as hell

  8. Dewey Higgins

    Definite skin saver. I read that it changes the cell structure, a REAL change to your skin, not just topical temporary stuff, i get it cheap from okdermo online store. Recommend

  9. Steven Parks

    Tretin is my chois due to its big tube size

  10. Glenn Lee

    Forget all other skincare products and claims. This is the HG of age fighters — and this is backed up by hundreds of scientific studies.

  11. Pablo

    It broke me out badly, after a month not using this, i still got a new acnes bcos of this.

  12. Roderick Gill

    Best treatment I have tried so far for acne but also the most potent and therefore should be used correctly and carefully.

  13. Noah

    My pores first got big and weird, and the skin on my forehead began to grey out and get a coarse texture. I was afraid but persisted through the “dark night”. Eventually the coarse skin went away especially when I did salicylic acid. Although I don’t have pure “baby skin” since I didn’t peel in sheets, tretinoin has “calmed down” my skin a lot and I feel that I now have more of a clean slate

  14. Daryl Morrison

    Would use this forever 🙂

  15. Myron Yates

    Cheap, love it

  16. Ronald B

    Treated my acne

  17. Tim

    USE SUNSCREEN in the morning. Its not an option, its a most!!!

  18. Ellis Bailey

    Best money i’ve ever spent on my skin

  19. Paul S

    My ex girlfriend turned me onto Retin A as she has beautiful skin. I have been using .05% and mixed it with a night moisturizer and pine cone extract. The colour is a bit dark as the extract is brown. After 3 months of nightly use the results are amazing when used in this combo. My crows feet around my eyes are almost unnoticeable. The wrinkles that used to be on my forehead are gone. I don’t wake up with bags under my eyes either. I’m 54 and people comment that I look years younger as my skin is radiant and glows. My miracle cream…

  20. Guy Chandler

    It will most likely dry out your skin a bit in the beginning, you will probably get some flakiness and peeling. Give it some time and peeling will eventually stop, it’s part of the exfoliating process. I would highly recommend starting with lower concentration initially. And start slow, once every few days or so and slowly build up. Also remember to balance out the dryness with good oil-free mositurizer.

  21. Ian

    Best product ever and a very cheap price as well, seems legit and in a metal tube as it should be. Thanx okdermo

  22. Juan Mann

    Nice big tube, very efficient!

  23. Wesley C

    it is really excellent for both photoaging as well as acne. Initially my acne got worse but I got a good result after 1 month of its use . Strongly recommended

  24. Doug Olson

    The biggest tube i’ve ever seen, thanx!

  25. Antonio B

    Yes it made my skin flake. But underneath was the most beautiful healthy skin!!!

  26. Kenny Rodriguez

    I live in sunny California and I waited till November when the sun is less harsh to start. I’ve been using Tretin 0.025% for a bit more than 9 months. I have sensitive rosacea prone skin and it took me some time to build up my skin tolerance to this cream. I’ve started by using it ones a week (my skin was pink and peeling terribly) and built it up to three times a week without any visible irritation. Do I notice any improvement? – It keeps my rosacea fully invisible, but I don’t see any anti-aging benefits, unfortunately, maybe strength is not so high as required.

  27. Scott

    0.025 no effect on my skin, ordered 0.05% strength

  28. Ignacio H

    My skin became more youthful, without pigmentation, brighter, wrinkles and fine lines became less visible and its only within first 2 months of usage, I’m very impressed! Thank you, tretinoin!

  29. Ricky

    With love!

  30. Frederick

    This is an amazing product for acne and hyperpigmentation

  31. Salvador Reese


  32. Tommy Evans

    This stuff made my face bleed! I tried using it every other night, every 3 nights, etc….but my face looked like it had been burned. It was so painful. Went back to dermatologist and got switched to Adapalene and its working wonders and not pain like tretinoin did.

  33. Kristopher Gibbs

    Tretin cream helps to speed up the fading and healing of my acne scars. New scars peel away completely within a week. Old scars are more stubborn though but definitely faded significantly.

  34. Emanuel J

    I’m 68 and have used Tretinoin for four months. The first 2-3 weeks of use my skin did peel and burn. After putting this product on at night, I use an oil serum and a night moisturizer. It helps to soothe my skin. I love this product and I get so many compliments on my smooth and younger looking skin. If you’re getting your face waxed, don’t use this 1-2 days before. My skin burned. I use daily moisturizer and sunscreen daily over Tretinoin.

  35. Sam P

    I want to use it all my life, would recommend it to everyone who has signs of aging, acne, wrinkles, color fading, discoloration etc problems.

  36. Randy

    I am using a pea size amount all over the face at night. Can take a few months to see results so I will update you. Must wear SPF! So far it’s too irritating for me to use daily.

  37. Rene Garcia

    Tretin cream made my skin VERY DRY. I never had a dry skin before!

  38. Leo

    With some patience, this cream can give you good results. It seriously even out my skin and greatly shorten the life span of my acne. Great product that every woman should try.

  39. Carroll Hogan

    5 stars because it works, only when I workout my face burns from sweating (real bad) . My face turns red, the whole day, & itchy. Planning to have a wet towel next time, and pat before it boils my skin

  40. Wm D

    Thanx for great product!

  41. Erik Houston

    I really have a love/hate relationship with with my Tretin tretinoin 0.05% cream. It peels my skin but it works as well

  42. Dr.Simmonth

    excellent product… will reorder, but order in advance because delivery taking time

  43. Allen Kim

    I’m definitely impatient regarding skin products, but after having read multiple of reviews from people that have used this for years, I now know that patience is key and you will get results accordingly.

  44. Rodolfo

    Overall, I really really like tretinoin Tretin cream, it cleared up my skin quickly and nicely. Its side effects are a pain in the butt to deal with but I get lots of compliments on my skin now and definitely feel better about it. I have had friends try this product and have the complete opposite affect so it really depends on the person.

  45. Brad Chavez

    Use it only at night and follow the instructions. DO NOT put it on right after the shower, the mositure on your skin will worsen the peeling. Wait for 15 minutes, then apply the cream. DO NOT use it as a spot treatment, instead take a pea sized amount and then gently spread out on your skin. Using it as a spot treatment will also worsen the peeling. The cream is also great for fading acne scars and preventing wrinkle, so it will exfoliat your skin all around. At last wait for an hour for the cream to sink in then apply oil free moisturizer. Another option is to do all your routine first and wait for some time, then put this on right before going to bed.

  46. Dwight Casey

    Im a religius retinol user, since 5 years ago (im 32 now) once i hit 30 i started to use tretinoin (Tretin brand) and no more on the counter expensive retinol creams. it helped me with my acne scars from my youth and cleaned up my pores. i only used it one week straight at night then off for two weeks and then a week again. just make sure to use a very good spf in the morning and since it can be very drying i like to use it a pea size amount after my hydrating toner/lotion (i use hyalugel hyaluronic acid gel) let it sit for 30mnt and moisturise with any medical grade stuff.

  47. Simon Webster

    Good luck. Don’t go too fast with this stuff. It can burn. Patience is key! For the love of God, stay out of the sun and always wear SPF 30+.

  48. Clarence Gonzalez

    When and if you feel it is time to get serious about skincare, whatever your concerns/needs, Tretinoin is the first course of action.

  49. Brendy F.

    Just received product so cant comment on effects yet, well packaged and shipping took around 2 weeks to US

  50. Lance M

    Do not like it glue smell and ugly tube

  51. Dave Butler

    I can’t walk in the sun without a parasol (sun umbrella) without burning my face.

  52. Michel & Steve

    This one in a huge tube, my favorite! Price is great as well, thank you for the opportunity to buy it! Especially thank you to Angela! 😉

  53. Julio Jenkins

    Finally!! Peeling is gone, my skin feels softer and I’ve got a beautiful rosy glow. My pores do in fact look enlarged, and my skin feels more oily, but in general my skin looks better and smoother than before. No difference regarding lines, but blackheads/whiteheads seem to have diminished a bit. Curious to see how the next weeks will be like!

  54. Jose B

    I dilute it with my paraffin moisturizer, works great! You cannot find a better really working product on the market.

  55. Elaine R

    This is the best price you’re ever going to find on one of the best anti-aging products out there – tretinoin. Love this cream and thank you for the discount!

  56. Gilbert H

    Face is red after appication

  57. Phillip

    I wish I could use this, as it is the gold standard treatment for large pores and acne AND fine lines, but my poor skin can not take it. No matter how I space it out or apply it ( under or over lotion), my poor skin burns, flakes, peels and purges FOREVER.

  58. Suzanne M

    I also have only been using this for a few days but a little goes a long way so it will last for a really long time in this 30g tube, got from the fresh stock, amazed by the professionalism of the company. I am also hopeful about the results.

  59. Miranda Silver

    Just as effective as retin-a…. only less expensive

  60. Cary George

    It lasts for a year! Woah, thank you okdermo for affordable price!

  61. Gerard Hanson


  62. Samuel Lawson

    Definitely recommend Tretin cream for aging skin, firstly recommend to use low-tretinoin consistency 0.025% and after go deeper with 0.05% and 0.1% creams. My skin became more youthful, without pigmentation, brighter, wrinkles and fine lines became less visible and its only within first 2 months of usage, i’m pretty impressed! Thanks Tretin! Will use it all my life, would recommend it to everyone who have signs of aging, wrinkles, color fading, discoloration etc problems. My doctors say that they dont prescribe tretinoin for anti-aging purposes. So I got it without doc (thanks

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