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Regen-D® Epidermal Growth Factor Gel

Recombinant Human Epidermal Growth Factor 60mg / 150mg

(3 customer reviews)

From USD $75.00

Regranex alternative gel Regen-D 60mg/150mg is the recombinant platelet-derived growth factor (PDGF) therapy for diabetic neuropathic ulcers and also for anti-aging purposes.

Endogenous PDGF is the trigger that initiates healing by attracting repair cells to wounds. Platelet-derived growth factor (PDGF) works to stimulate fibroblast proliferation to increase the growth of granulation tissue, increase the rate of re-epithelialization and revascularization, and promote natural collagen production.

Regen-D 60mg/120mg (rhEGF, aka Epidermal Growth Factor) is a topical gel prescribed to those who require rapid regrowth or strengthening of the skin for a variety of reasons, mostly for quick wound healing.

EGF is one of the most important growth factor proteins in our skin and plays a vital role in the production of collagen, elastin, and hyaluronic acid to maintain the skin’s healthy, dense, and youthful appearance. If we imagine a baby’s skin, it is so thick and plump, because it is full of EGF.

Regen-D 150 Gel works by releasing a growth factor that causes skin regeneration in diabetic foot ulcers. It reduces the healing time and promotes skin regeneration by the formation of new skin cells at the site of the wound.

📍 Patient Product Information

📍 REGEN-D 60/150 Brochure

Size: 15g / 0.53oz
Brand name: Regranex, TNS, Fibroblast, Growth Factor
Title Range Discount
Items: 2 - 4 5%
Items: 5 - 8 10%
Items: 9 + 15%



Regen-D contains skin growth hormones Ranitidine / Dicyclomine / Simethicone which act on the skin cells to encourage rapid reproduction and natural strengthening. This makes it useful for those who have recently had a skin graft operation or a recent injury causing abrasion or an open wound. It has also shown effectiveness for the rejuvenation of the skin for cosmetic reasons. Your dermatologist may prescribe this medication for the treatment of other unlisted conditions, as well. Regen-D 150 Gel is a medicine that helps in the faster healing of ulcers (sores) of the leg, ankle, or foot in diabetic patients.

Regen-D 60-150 (Epidermal Growth Factor) is a topical gel prescribed to those who require rapid regrowth or strengthening of the skin for a variety of reasons. Regen-D 60mg or 150mg is an alternative to  Regranex Gel, which contains growth hormones rhEGF (Ranitidine / Dicyclomine / Simethicone) that act on the skin cells to encourage rapid reproduction and natural strengthening. This makes it useful for those who have recently had a skin graft operation or a recent injury causing abrasion or an open wound. It has also shown effectiveness for the rejuvenation of the skin for cosmetic reasons. Your dermatologist may prescribe this medication for the treatment of other unlisted conditions, as well.

Regen-D 60-150 ® is Human Epidermal Growth Factors re GF produced by recombinant technology and is a new generation therapy with a novel factor used for first and second-degree burns, skin grafts, and bedsores. Regen-D 60-150 ® has been widely researched and documented with published data and an International patent as well. Regen-D 60 ® Gel regenerates faster and halves the healing time took first & second-degree burns, skin grafts, and bedsores. Regen-D ® was awarded an Innovation Award by Marico Foundation World for its product and process innovation.

Recombinant human epidermal growth factor (REGEN-D 150), which was cloned and overexpressed in E. coli, has shown enhanced healing of chronic diabetic foot ulcers (DFU) by significantly reducing the duration of healing in addition to providing excellent quality of wound healing and re-epithelization. The post-marketing surveillance (PMS) study of REGEN-D 150 in 135 patients of DFU was compared with Phase III clinical trial data of REGEN-D 150. Statistical analysis of study data determined that the empirical survival probability distribution, in terms of non-healing of ulcers, was lowest in the case of the PMS study, better than that for Phase III; more DFU patients were healed in the PMS study. The percentage of patients cured in any given week (e.g., in week 10) is above 90% in the PMS study, as compared to 69% in Phase III clinical trial; this percentage was around 18% for the control group with placebo in the Phase III trial. The average wound healing time was significantly lower in the PMS study, 4.8 weeks, while it was 9 weeks in Phase III clinical trials while the average wound healing with REGEN-D 150 was found to be 86% in this study. REGEN-D 150 has been found to result in healthy granulation and stimulate epithelization, thus leading to final wound closure. The PMS study has established the efficacy of REGEN-D 150 in faster healing of diabetic foot ulcers.

The healing effect of recombinant human epidermal growth factor (EGF) on chronic diabetic foot ulcers is shown in this article. A total of 89 patients (65 male and 24 female) aged from 36 to 82 years (average of 54) enrolled for the prospective, open-label trial, crossover study. Predetermined criteria were used for the diagnosis and classification of ulcers. The average duration of the ulcer was 6 months (ranging from 3 to 27 months) prior to the study. Upon study, the ulcers were debrided and treated with hydrocolloid or composite dressing depending on the condition of the wound. If the treatment effect was minimal using advanced dressing for 3 weeks, patients were crossed over to twice-a-day treatment with 0.005% EGF and advanced dressing. Among the patients, 21 patients showed improvement using hydrocolloid or composite dressing alone and 68 patients were crossed over to treatment with EGF and advanced dressing. In the EGF-treated patients, complete healing was noted in 52 patients within an average of 46 days (ranging from 2 to 14 weeks). Recurrence was not noted during the 6-month observation. But 5 patients showed new lesions different from the prior site. Sixteen patients required further interventions. This paper suggests that topical treatment with EGF combined with advanced dressing may have positive effects in promoting the healing of chronic diabetic foot wounds.

Regen D is a recombinant human epidermal growth factor gel that promotes skin repair in conditions like diabetic ulcers and skin wounds or burns. It acts on connective tissue cells to rapidly repair and regenerate severely damaged skin areas. Additionally, growth factors reverse the aging effect on skin through their potent skin renovation abilities.

Regen D is a topical gel indicated for patients that require quick skin repair and strengthening. It has been used for skin grafts, open wounds, ulcers, and conditions that profoundly alter skin integrity. Moreover, growth factors have cosmetic potential. They strengthen and renew skin structure by Boosting collagen production, enhancing skin blood supply, and slowing cellular death.

Regen D contains three skin growth hormones: ranitidine, dicyclomine, and simethicone. It leads to thicker and firmer skin with subsequent lesser wrinkles and fine lines appearance.
The potent rejuvenating and repairing properties of Regen D skin growth factors translate to youthful and elastic skin. Hence, regen D reduces wrinkles and fine line appearances. Moreover, it evens out the skin tone, clearing dark spots and discolorations.

In addition to its age-fighting effect, Regen D helps in healing profound wounds and preventing scar formation. It induces connective tissue cells to produce collagen and rapidly repair damaged areas.

Regen D has the potential for a potent age-fighting skin cosmetic. It is a rapid fix for damaged skin and the answer for glowing, toned, firm, youthful skin.

Recombinant platelet-derived growth factor therapy

Regen-D® Gel, a natural formulation for skin is actually a recombinant platelet-derived growth factor therapy for diabetic and neuropathic ulcers. This endogenous growth factor stimulates healing by attracting repair cells to the wound. The platelet growth factor promotes collagen production and increases the rate of skin cell regeneration. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes-macrophages and fibroblasts in vitro, cell types considered essential for tissue repair.

Regen-D® Gel 60mg and 120 mg formulation is an ideal one for those requiring rapid growth and strengthening of the skin for fast wound healing. Regen-D® Gel 150 mg helps in faster healing of ulcers of the neck, ankle, and foot in diabetic patients.

A formula with three growth factors: Regen-D® Gel gel by OKdermo contains three skin growth hormones that are ranitidine, dicyclomine, and simethicone. All these three hormones thicken and firm the skin, ultimately reducing the appearance of fine lines, wrinkles, and scars. This natural formulation for the skin also reduces hyperpigmentation and evens the skin tone. These benefits make Regen-D® Gel an ideal cosmetic formulation for fighting premature skin aging for smooth and fresh skin.

Science-backed technology: None of our products are marketed and supplied without clinical trials and scientific research. All of OKdermo’s skincare products & treatments including moisturizers, cleansers, serums, skin tone and wrinkle regimens, and creams for eyes are clinically proven for their safety and efficacy. Our products are biocompatible, vegan, cruelty-free, and paraben-free. Moreover, no artificial colorants or flavors are added.

How do human epidermal recombinant growth factors regenerate skin repair and renewal?

Growth factors are not hormones. They are substances naturally produced by platelets, skin cells, or connective tissue to support the repair of damaged skin. As with most biological processes in an aging body, the growth factor production declines with age. Subsequently, the skin’s ability to repair itself also decreases. Hence, dermatologists concluded the connection between high levels of growth factors and youthful skin.

Topically applied growth factors have a large size. But trials showed that their size does not affect their absorption and penetration to the skin. Growth factors combined with antioxidants like vitamin C or Vitamin E boost their efficiency and show sooner results, reducing wrinkles and fine lines typically in 6 to 8 weeks.

The growth factors are natural agents produced by the skin to repair damage caused by environmental factors like UV rays or trauma. As the largest organ in the body with a vast surface exposed to the external world, The skin is prone to regular damage. Hence, the skin is in a constant state of renewal and regeneration to resist daily tear and wear.

Growth factors used in cosmetics are the product of bioengineered cells in the laboratory. Biotechnology makes it possible to grow skin or bone cells that produce growth factors to isolate later for cosmetic use.

In conclusion, no growth factors induce cellular pathways that lead to enhanced collagen and elastic fibers production. Regen D gel combines multiple growth factors for maximum skin firmness and softness.


Regen-D (Recombinant Human Epidermal Growth Factor) should be used according to the instructions provided by your doctor and included with the packaging to get the most effective results from treatment. Regen-D 60-150 (Epidermal Growth Factor) Gel is normally applied once each day, but your individual directions will depend on your age, weight, health condition, and the severity of your symptoms. To apply the Regen-D 60 Gel gently rinse and dry the area to remove any dirt or loose skin, apply a small amount of cream, and gently massage it into the skin if possible. Leave the area being treated open to the air following each administration to allow any excess medication to evaporate. Wash your hands using soap and water after each application to prevent them from contacting any mucous membranes or areas not being treated.

Use Regen-D once per day. Wash and clean the skin to remove any dirt, apply the gel, and gently massage. Leave the area being applied open to air to allow any extra medication to evaporate.
OKdermo aims to supply you with a 100% authentic and pure formulation of Regen gel that is the best solution for dark circles. OKdermo is determined to supply original and high-quality products only from reputable manufacturers. To explore more about our skincare products, visit our website.


  • Mild stinging or burning sensations
  • Dry, flaking, or peeling skin
  • Slight redness or discoloration
  • Discoloration of the skin

Stop using the medication and contact your dermatologist immediately if you experience any serious side effects such as severe pain or signs of an allergic reaction such as hives, skin rashes, swelling, or difficulty breathing. These conditions may require reduced application frequency or immediate medical attention in serious cases to prevent further health problems from occurring.

Regen-D 60-150 (Recombinant Human Epidermal Growth Factor) should not be used by users with a history of allergic reactions to similar conditions. You are also suggested to have your dermatologist perform a health check before beginning use of the Regen-D 60 Gel to ensure you do not have any chronic health conditions that may cause unexpected complications.

Strictly use Regen-D 60-150 Gel (Recombinant Human Epidermal Growth Factor) as prescribed and follow all instructions provided by your doctor. Regen-D 60 (Recombinant Human Epidermal Growth Factor) may not be safe or suitable for everyone. Always ensure your dermatologist is informed if you are pregnant or breastfeeding, using any other type of medication (including non-prescription medicine, vitamins, and supplements), as well as if you have any allergies, other illnesses, or pre-existing medication conditions.

Safety Information

Regen-D Gel is indicated for the treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond and have an adequate blood supply when used as an adjunct to, and not a substitute for, good ulcer care practices.

The efficacy of Regen-D Gel has not been established for the treatment of pressure ulcers and venous stasis ulcers.

The effects of Regen-D Gel on exposed joints, tendons, ligaments, and bones have not been established in humans.

Regen-D Gel is a non-sterile, low-bioburden preserved product. Therefore, it should not be used in wounds that are close to the primary intention. Malignancies distant from the site of application have been reported in both a clinical study and in postmarketing use. The benefits and risks of Regen-D Gel treatment should be carefully evaluated before prescribing to patients with known malignancy.

Recombinant Human Epidermal Growth Factor Gel

Additional Information


Growth hormones rhEGF (Ranitidine / Dicyclomine / Simethicone) 60mg or 150mg