Triluma® Hydroquinone 4% + Tretinoin 0.05% + Fluocinolone 0.01% Cream 15g

Rated 5.00 out of 5 based on 4 customer ratings
(4 customer reviews)


✓ Potent melasma remover with 3 active ingredients

✓ A powerful depigmenting agent to help lighten the skin

✓ Reducing inflammation – help heal the skin

✓ A vitamin-A derivative which protects & increasing exfoliation

✓ A short‐term (up to 8 weeks) treatment of severe melasma

✓ Reputable manufacturer Galderma

Triluma cream with active substances fluocinolone, hydroquinone, and tretinoin is a high-quality affordable analog/alternative to Tri-Luma cream for skin hyperpigmentation removal with the same active ingredients.

Triluma is a triple combination cream which works for melasma, skin hyperpigmentation, dark spots, freckles, other skin dark discolorations by lightening the skin, reducing inflammation and increasing exfoliation.

Tri Luma should always be used in conjunction with sun-avoidance measures, like using strong sunscreens and wearing protective clothing. Lumacip Plus may improve the appearance of melasma but is not a cure.

Tri-Luma cream has two versions: with mild strength components – Hydroquinone 2%/Tretinoin 0.025%/Fluocinolone Acetonide 0.01%  and a version with moderate strength components: Hydroquinone 4%/Tretinoin 0.05%/Fluocinolone 0.01% active ingredients is designed for topical treatment of dark, black and brown spots, skin hyperpigmentation conditions, melasma, and freckles.



What is TriLuma RD® cream

TriLuma is an anti-melasma cream with 3 active ingredients, uniquely combined and more effective than solutions containing only two of the ingredients. A unique triple-combination topical therapy for the short-term (8-week) treatment of the dark spots associated with moderate-to-severe facial melasma. Fluocinolone 0.01 to reduces inflammation, Hydroquinone 4 (depigmenting agent) lightens the skin, and Tretinoin 0.05 is increasing the skin cell turnover rate – helps exfoliate the skin.

Melasma is a skin condition which affects the appearance of the facial skin, causing brown patches to appear. These are due to excess melanin production (the pigment that gives the skin its color). It could be related to pregnancy or pills which have been taken by the affected person, sunlight is also believed to trigger it.

Tri-Luma RD cream has two versions: with mild strength components – Hydroquinone 2%/Tretinoin 0.025%/Fluocinolone Acetonide 0.01%  and version with moderate strength components: Hydroquinone 4%/Tretinoin 0.05%/Fluocinolone 0.01% active ingredients is designed for topical treatment of dark, black and brown spots, skin hyperpigmentation conditions, melasma, and freckles.

Triluma RD cream is an analog/alternative of famous Tri-luma with identical composition. TriLuma RD cream made by reputable Galderma manufacturer has two strengths: twice weaker from original Tri-Luma cream but still very effective solution Tri-Luma RD against mild hyperpigmentation problems, and Tri-Luma original strength composition for severe hyperpigmentation cases. Not recommended to use Tri-Luma RD cream longer than 4 months in a row. Tri Luma RD should always be used in accordance with the instructions of your dermatologist.

TriLuma-RD® cream is made by reputable Galderma and it is a topical skin cream used to treat melasma, a chronic skin hyperpigmentation characterized by symmetrical, blotchy, brownish facial pigmentation. Melasma/chloasma is caused by overproduction of melanin by the pigment-producing cells melanocytes. Tri Luma RD cream contains a combination of three active agents:

  • Hydroquinone 4% – skin depigmenting agent flawlessly blocks the melanin, and evens skin tone;
  • Tretinoin 0.05% – synthetic vitamin A, it renews the skin;
  • Fluocinolone acetonide 0.01% – anti-inflammatory agent, helps to heal the skin, reducing the inflammation.

Hydroquinone 4%: The production of melanin is controlled by the enzyme tyrosine, which is found in the melanosomes of melanocytes. Hydroquinone 2% in Triluma RD cream is a tyrosinase inhibitor that works by blocking the action of tyrosinase, which inhibits the formation of melanin by melanocytes. It also increases the breakdown of melanosomes that contain the melanin. As the amount of melanin produced decreases the darkened skin gradually lightens to match normal skin color.

Tretinoin 0.05%: Tretinoin in cream is an active metabolite of Vitamin A and is a keratolytic medicated retinol that works by binding to specific retinoic acid receptors in the nucleus of skin cells and affects the way skin cells behave, which regulates cell growth and differentiation; it also has anti-inflammatory properties. Tretinoin 0.05% is thought to act by enhancing skin epithelial cell proliferation and accelerating epithelial differentiation; it also blocks the hardening processes of the outer skin layer (keratinization and cornification) and increases the shedding of old hardened skin cells, while at the same time promoting the growth of new skin cells. The combined effect of these actions is to speed up skin cell turnover which has the effect of lightening the skin.

Fluocinolone Acetonide 0.01%: Triluma-RD cream also contains the synthetic mild anti-inflammatory component, which is a medium potency anti-inflammatory that is often used for topical application as it concentrates in the skin but does not enter the blood circulation and, therefore, has the minimal systemic effect. Fluocinolone acetonide 0.01% in cream works by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes; and also narrows and constricts causes blood vessels that have become dilated (widened) and leaky allowing other inflammatory cells into the skin to escalate the inflammatory response. The anti-inflammatory actions of Fluocinolone in Triluma-RD cream reduce the risk of developing contact dermatitis that may be caused by other Triluma-RD cream components like hydroquinone and tretinoin. This combination of strong ingredients for treatment of melasma has been found to provide better improvement than treatment with a single-component cream like plane hydroquinone or tretinoin exfoliator.

Other ingredients (excipients): butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, Methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol. Triluma has an alternative cream made by Cipla named Lumacip Plus, but it is discontinued. Triluma-RD cream is also an alternative cream to Pigmanorm creme amazon online, suitable to reduce pigmentation and treat melasma.

Triluma cream key ingredients

  • Fluocinolone 0.01 is classified as a mild anti-inflammatory component and it is said to work by reducing inflammation on the skin.
  • Hydroquinone 4 also called dihydroxybenzene is a topical skin brightening agent which works by inhibiting the action of an enzyme called tyrosinase. This, in turn, helps to prevent the formation of melanin and contributes to skin depigmentation, allowing for the melanin patches to become brighter.
  • Tretinoin 0.05 also called all-trans retinoic acid – is a form of vitamin A which plays a key role in cellular growth and regeneration. Topical application helps to rejuvenate and revitalize the surface of the skin.

How TriLuma RD Hydroquinone 4 + Tretinoin 0.05 cream works

Tri-Luma RD cream provides fast results for skin hyperpigmentation treatment even after first 6-8 weeks of application, approved by FDA and contains with 3 active ingredients. The term hyperpigmentation refers to the dark, discolored patches of skin that occur when melanin is overproduced. Reasons for this overproduction include sun exposure, skin damage, hormones, and certain medications. The condition is typically harmless, though its appearance on prominent areas of the body, such as the face, can affect your self-esteem. Fortunately, there are several over-the-counter fade creams intended for home use. At-home creams and lotions lighten dark spots over time and offer a less-expensive, less-invasive alternative to professional treatments. Consult a professional to determine one that is suitable for you.

Tri Luma RD cream works by decreasing melanin production in skin cells – melanocytes with the help of hydroquinone 4% salts, tretinoin 0.05% component help to shred and pill an older and darker skin part, fluocinolone acetonide 0.01% protect skin from inflammations.

Melasma condition is spread thought persons who have a genetic predisposition and may be triggered by various factors including sun exposure, pregnancy, hormone treatments, some toiletries, and low thyroid hormone condition. TriLuma RD cream is a powerful 3-way combination treatment that lightens the skin and reduces the risk of dermatitis, inflammation of the skin that can be associated with using skin lighteners alone to treat melasma. Triluma cream contains 3 different ingredients which are anti-inflammatory component Fluocinolone 0.01 + keratolytic, mild peel and skin repair agent  Tretinoin 0.05 + OTC grade topical skin lightener agent Hydroquinone 2.

How to use TriLuma RD Hydroquinone 4 + Tretinoin 0.05 cream

Wash your face with soap and lukewarm water, then pat dry. Refrain from using harsh cleansers, as these can dry out and irritate the skin.

Apply the TriLuma RD cream to the treatment area. Rub it in well, making sure that the medication stays within the patches of discoloration. Hydroquinone 2% is a bleaching agent that works by preventing melanin production. It affects both abnormally and normally pigmented skin; therefore, application outside of the intended treatment area can result in spots of lighter-than-average pigmentation.

Wash your hands to remove any remaining TriLuma RD cream. Recommended using the treatment once a day, at least 30 minutes before bedtime. During the day, wear a broad-spectrum SPF 15 sunscreen or moisturizer to prevent hyperpigmented areas from further darkening.

Triluma cream should always be used as instructed by your dermatologist. To use the cream correctly, follow these steps:

  • Apply Triluma cream at night, at least 30 minutes before bedtime;
  • Gently wash your face with a mild cleanser. Don’t use a washcloth to apply the cleanser, just your fingers. Rinse and pat your skin dry;
  • Put a small amount (pea sized or ½ inch or less) of Triluma cream on your fingertip. Apply a thin coat onto the discolored spot(s). Include about ½ inch of normal skin surrounding the affected area;
  • After you have used the cream for a while, you may find that you need slightly less to do the job;
  • Rub the cream lightly and uniformly into your skin. The cream should become invisible almost at once. If you can still see it, you are using too much;
  • Keep the cream away from the corners of your nose, your mouth, eyes an, open wounds. Spread it away from those areas when applying it;
  • Do not use more Triluma cream or apply it more often than recommended by your dermatologist. Too much Triluma cream may irritate your skin and won’t give you faster or better results;
  • Do not cover the treated area with anything after applying the cream;
  • During use of Triluma cream, you may experience redness, peeling, burning, dryness, itching or other skin irritation. If your skin gets too irritated, stop using the cream, and let your dermatologist know;
  • Triluma cream may also cause a gradual blue-black darkening of your skin; if this happens, stop using the product immediately and speak to your dermatologist;
  • To help avoid skin dryness, you may use a moisturizer in the morning after you wash your face. You may also use a moisturizer and cosmetics during the day;
  • Use a sunscreen of at least SPF 30 and a wide-brimmed hat over the treated areas. It requires only a small amount of sunlight—not just a sunburn—to worsen melasma;
  • If you do get sunburned, stop using the cream until your skin is healed. After stopping treatment with Triluma cream, continue to protect your skin from sunlight;
  • Only your dermatologist knows which other drugs may be helpful during treatment and will tell you about them if needed. Do not use other medicines unless your dermatologist approves them.

Tri-luma generic cream is indicated for topical application. Strict compliance with the instructions given by your dermatologist will be needed at all times. This cream works best if used at night, and dermatologists generally advise applying it 30 minutes before you go to bed. However, you may wish to wash your face before applying the cream, after which it should be gently patted dry.

Your dermatologist may tell you to apply a small amount (1/2 inch) of cream onto the fingertip, after which it should be thinly coated onto the areas affected by hyperpigmentation. The cream should be gently rubbed into the skin, taking care to ensure that it doesn`t get into the mouth, eyes or nose. Generally, treatment is continued for a short period of time (8 weeks). After full treatment period recommended to use naturally derived azelaic acid 20% cream to protect, lighten and regenerate skin upper layer.

Contraindications when using Triluma-RD cream

Tri Luma RD should always be used in accordance with the instructions of your dermatologist. Pregnancy and lactation, acute inflammation (including eczema) lesions of the skin (dermatitis, seborrhea, and others), rosacea, skin lesions (wounds, burns, etc), photosensitivity, diseases of the rectum, of liver or kidney, Addison’s disease, asthma, allergic to sulfites, or to any of the components of the cream, hypersensitivity to any component of the cream (discontinue use and consult a dermatologist if you have any of these symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat).

Side effects: redness, peeling, burning, dryness, and itching at the site of application. Discontinue use and notify your dermatologist if you have any of the following side effects: darkening of the treated skin, strong irritation of the skin, the formation of bubbles, dribbling, scaling or crusting, painful burning or swelling of the skin, any type of breathing problems, irritation of your eyes, nose or mouth.

Triluma cream side effects

If you notice any signs of side effects during application and usage of Triluma cream with main ingredients Fluocinolone / Hydroquinone / Tretinoin, ensure that you notify your dermatologist. The following side effects are widespread: acne, dry skin, erythema, itchy feeling, peeling of the skin, should you notice black-blue discoloration appearing on the skin or severe irritation visit your dermatologist straight away.

Triluma cream precautions

Triluma (Fluocinolone Acetonide/Hydroquinone/Tretinoin) cream is for topical use only. Do not use abrasive cleaning products, soaps or other cosmetic products which produce a drying effect or which have high alcohol or astringent levels. Ask your dermatologist about which cleansers are safe for use during Triluma cream applications.

Application of Triluma is also known as Tri-Luma cream alternative can make it easier for your skin to become sunburned. Therefore, stay out of the sun whenever possible, and protect yourself with long-sleeved clothing, a cap, and other protective clothing if you must go outside. Also recommended to use strong SPF lotions against UV sunlight rays.

Indication: Triluma cream is indicated for the short‐term (up to 8 weeks) treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreens.

Adverse events: In the controlled clinical trials, the most frequently reported events were redness, peeling, burning, dryness, and itching at the site of application.

Warnings/Precautions: Triluma contains sulfites which may cause severe, life‐threatening allergic reactions in people allergic to sulfites. Triluma contains hydroquinone, which may cause a gradual blue‐black darkening of the skin. If you are pregnant, nursing or trying to become pregnant you should not use Triluma. Safety and efficacy have not been established in individuals with darker skin. Reversible HPA axis (adrenal function) suppression may result from exposure to the topical fluocinolone, so discontinue use if signs and symptoms of this condition occur. Avoid products that may dry or irritate the skin, such as abrasive cleansers, scrubs, or skin‐peeling agents. Exposure to sunlight, sunlamps, or UV light and extreme heat, wind, or cold should be avoided. If exposure cannot be avoided, sunscreen products [SPF 30 or more] and protective apparel should be used.

Creams to get rid of freckles

Freckles appear as small spots of skin discoloration, often dotting your face, chest, shoulders, arms and legs. Freckles may detract from the flawless, even skin tone you want and may even be an important indicator of skin cancer risks. Several skin care creams like TriLuma RD cream from Galderma can help you fade and lighten freckles. 2% Hydroquinone component of this cream works by inhibiting skin pigment production and bleaching the skin cells. It’s effective for fading hyperpigmented skin conditions like freckles. Once faded, the results may last for up to one year before you need additional hydroquinone treatments. Numerous creams in store contain hydroquinone at concentrations of approximately 2 percent to 5 percent and will effectively lighten your freckles within two months. Everyone has to follow the total sun avoidance program during the treatment and always consult your dermatologist prior using TriLuma-RD cream.

Additional information


Hydroquinone 2%/Tretinoin 0.025%, Hydroquinone 4%/Tretinoin 0.05%


  • Hydroquinone 2%
  • Tretinoin 0.025%
  • Fluocinolone acetonide 0.01%

Other ingredients: butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol.

4 reviews for Triluma® Hydroquinone 4% + Tretinoin 0.05% + Fluocinolone 0.01% Cream 15g

  1. Rated 5 out of 5

    Yolanda R.

    Pretty good results, thank you!

  2. Rated 5 out of 5


    I began to see results within two weeks. The dark patches and mottled appearance of my skin has almost completely disappeared. I have received several compliments on how clear my skin looks. A little goes long way so don’t use too much. The results are fantastic! The price is brllliant, youve never find cheaper triluma analogs with then in okdermo!! Thanks to you!

  3. Rated 5 out of 5

    Ritah N.

    Been using this product for almost a month and I can say it really is clearing up my melasma, lighten up scars. I really can’t wait to see how my skin will look by December!

  4. Rated 5 out of 5

    Mommy Love

    Wow thank you! One fifth the price of tri luma , works exactly the same!

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