Tri-Luma® Melasma Treatment Cream

Hydroquinone 2% / 4% + Tretinoin 0.012% / 0.05% + Fluocinolone 0.01%

4.50 out of 5

(44 customer reviews)

From USD $28.00

✓ Potent melasma remover with 3 active ingredients

✓ A powerful depigmenting agent to help lighten the skin

✓ Reducing inflammation – helps heal the skin

✓ A vitamin-A derivative which protects & increasing exfoliation

✓ A short‐term (up to 8 weeks) treatment of severe melasma

✓ Reputable manufacturers – Galderma and KLM Pharma

Size: 15g / 0.53oz, 20g / 0.7oz
Brand name: Lumiquin, Lumacip Plus, Refaquin, Retrieve

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What is Tri-Luma® cream?

Tri-Luma cream with active substances fluocinolone, hydroquinone, and tretinoin is a clinical strength high-quality cream for skin hyperpigmentation removal. Tri-Luma is a triple combination cream that works for melasma, skin hyperpigmentation, dark spots, freckles, dark discolorations. It lightens the skin, reducing inflammation, and increasing exfoliation. Tri-Luma should always be used in conjunction with sun-avoidance measures, like using strong sunscreens and wearing protective clothing, it dramatically improves the appearance of melasma. It is not recommended to use Tri-Luma cream longer than 5 months in a row. Tri-Luma RD should always be used in accordance with the instructions of your dermatologist.

Melasma is a skin condition that affects the appearance of the facial skin, causing brown patches to appear. These are due to excess melanin production (the pigment that gives the skin its color). It could be related to pregnancy or pills which have been taken by the affected person, sunlight is also believed to trigger it. Melasma also is known as chronic skin hyperpigmentation characterized by symmetrical, blotchy, brownish facial pigmentation. Melasma/chloasma is caused by the overproduction of melanin by the pigment-producing cells melanocytes.

Tri-Luma cream has two versions: with low-strength components – Hydroquinone 2%/Tretinoin 0.025%/Fluocinolone Acetonide 0.01%  and a version with high-strength components: Hydroquinone 4%/Tretinoin 0.05%/Fluocinolone 0.01% active ingredients that is designed for topical treatment of stubborn/severe hyperpigmentation cases and skin color issues. An anti-melasma cream with 3 active ingredients, uniquely combined and more effective than solutions containing only two of the ingredients. Manufactured by reputable Galderma, a unique triple-combination topical therapy for the short-term (8-week) treatment of the dark spots associated with moderate-to-severe facial melasma:

  • Hydroquinone 4% – skin depigmenting agent flawlessly blocks the melanin, and evens skin tone;
  • Tretinoin 0.05% – synthetic vitamin A, it renews the skin;
  • Fluocinolone acetonide 0.01% – anti-inflammatory agent, helps to heal the skin, reducing inflammation.

Hydroquinone 4%: The production of melanin is controlled by the enzyme tyrosine, which is found in the melanosomes of melanocytes. Hydroquinone 4% in Triluma cream is a tyrosinase inhibitor that works by blocking the action of tyrosinase, which inhibits the formation of melanin by melanocytes. It also increases the breakdown of melanosomes that contain melanin. As the amount of melanin produced decreases the darkened skin gradually lightens to match normal skin color.

Tretinoin 0.05%: Tretinoin in cream is an active metabolite of Vitamin A and is a keratolytic medicated retinol that works by binding to specific retinoic acid receptors in the nucleus of skin cells and affects the way skin cells behave, which regulates cell growth and differentiation; it also has anti-inflammatory properties. Tretinoin 0.05% is thought to act by enhancing skin epithelial cell proliferation and accelerating epithelial differentiation; it also blocks the hardening processes of the outer skin layer (keratinization and cornification) and increases the shedding of old hardened skin cells, while at the same time promoting the growth of new skin cells. The combined effect of these actions is to speed up skin cell turnover which has the effect of lightening the skin.

Fluocinolone Acetonide 0.01%: Triluma cream also contains the synthetic mild anti-inflammatory component, which is a medium potency anti-inflammatory that is often used for topical application as it concentrates in the skin but does not enter the blood circulation and, therefore, has the minimal systemic effect. Fluocinolone acetonide 0.01% in the cream works by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes; and also narrows and constricts causes blood vessels that have become dilated (widened) and leaky allowing other inflammatory cells into the skin to escalate the inflammatory response. The anti-inflammatory actions of Fluocinolone in Triluma cream reduce the risk of developing contact dermatitis that may be caused by other Triluma cream components like hydroquinone and tretinoin. This combination of strong ingredients for the treatment of melasma has been found to provide better improvement than treatment with a single-component cream like plane hydroquinone or tretinoin exfoliator.

Other ingredients (excipients): butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, Methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol.

Tri-Luma® Melasma Treatment Cream

Okdermo is committed to bringing you the best in health and wellness products. We partner with the leading companies to ensure the products we sell on our site meet high-quality standards. Tri-Luma Melasma Treatment Cream is a powerful blend of ingredients that work by lightening the skin and removing dark spots and melasma. It is a short-term treatment option for people experiencing unwanted dark spots.

Tri-Luma® Melasma Treatment Cream Uses

Tri-Luma® Melasma Treatment Cream is used to reduce dark spots on the facial skin caused by: Sun damage, Sun exposure, Hormones, Pregnancy, and Medications.

What is Melasma?

Melasma is a skin condition that affects the facial skin. It causes dark brown spots or patches to appear on the face. Melasma is sometimes related to pregnancy, but not always. It can also be caused by medications and other conditions. Melasma is caused by over production of melanin and is characterized by symmetrical and blotchy facial pigmentation.

How Tri-Luma® Melasma Treatment Cream Works

Tri-Luma® Melasma Treatment Cream is a short-term solution for people with melasma. It is specially formulated to lighten the appearance of dark spots by lightening the skin. People who use Tri-Luma® Melasma Treatment Cream generally experience noticeable results in 6-8 weeks of use. It has been FDA approved and is made by a reputable company.

How to Use Tri-Luma® Melasma Treatment Cream

If you are purchasing Tri-Luma® Melasma Treatment Cream, it is important that you use it properly. Before use, wash your face gently with a mild cleanser and warm water and make sure to completely dry your skin. Try to refrain from using harsh facial cleansers as they can dry out and irritate the skin, making it worse. After your face is clean, the next steps include:

  • Apply a small amount (pea-sized drop) of cream to clean, dry face.
  • Always apply about 30 minutes before bedtime.
  • Rub the cream gently into the skin and make sure to spread evenly.
  • Do not overuse — overuse of the cream will not result in better results.
  • Make sure to rub in fully so your skin absorbs the cream.
  • Avoid the eyes and mouth.
  • Do not cover the face with anything once the cream is applied.
  • Use a moisture cream in the mornings to keep the skin hydrated and from drying out.
  • During the day, wear sunscreen to protect your lightening skin.
  • Talk to your dermatologist if you experience any abnormal irritation such as itching, peeling, discoloration of the skin or severe irritation.

Order Tri-Luma® Melasma Treatment Cream

Okdermo is your source for skincare. You can order your melasma cream today without a prescription.

Tri Luma cream key active ingredients

Tri-Luma® Melasma Treatment Cream is a powerful blend of ingredients that work together to reduce melasma. The active ingredients include Hydroquinone, a skin depigmenting agent that flawlessly blocks melanin and evens out skin tone. Tretinoin, a synthetic vitamin that renews the skin. Fluocinolone, is an anti-inflammatory that helps to heal the skin and reduce inflammation. Tri-Luma Cream comes in two different strengths, low strength, and high strength.

  • Fluocinolone 0.01 is classified as a mild anti-inflammatory component and it is said to work by reducing inflammation on the skin.
  • Hydroquinone 4 also called dihydroxybenzene is a topical skin brightening agent that works by inhibiting the action of an enzyme called tyrosinase. This, in turn, helps to prevent the formation of melanin and contributes to skin depigmentation, allowing for the melanin patches to become brighter.
  • Tretinoin 0.05 also called all-trans retinoic acid – is a form of vitamin A which plays a key role in cellular growth and regeneration. Topical application helps to rejuvenate and revitalize the surface of the skin.

How Tri-Luma Hydroquinone 4 + Tretinoin 0.05 cream works

Tri-Luma cream provides fast results for skin hyperpigmentation treatment even after the first 6-8 weeks of application, approved by FDA, and contains 3 active ingredients. The term hyperpigmentation refers to the dark, discolored patches of skin that occur when melanin is overproduced. Reasons for this overproduction include sun exposure, skin damage, hormones, and certain medications. The condition is typically harmless, though its appearance on prominent areas of the body, such as the face, can affect your self-esteem. Fortunately, there are several over-the-counter fade creams intended for home use. At-home creams and lotions lighten dark spots over time and offer a less-expensive, less-invasive alternative to professional treatments. Consult a professional to determine one that is suitable for you.

Tri-Luma cream works by decreasing melanin production in skin cells – melanocytes with the help of hydroquinone 4% salts, tretinoin 0.05% component help to shred and pill an older and darker skin part, fluocinolone acetonide 0.01% protect skin from inflammations.

Melasma condition is spread through persons who have a genetic predisposition and may be triggered by various factors including sun exposure, pregnancy, hormone treatments, some toiletries, and low thyroid hormone conditions. TriLuma cream is a powerful 3-way combination treatment that lightens the skin and reduces the risk of dermatitis, inflammation of the skin that can be associated with using skin lighteners alone to treat melasma. Tri-luma cream contains 3 different ingredients which are anti-inflammatory component Fluocinolone 0.01 + keratolytic, mild peel, and skin repair agent  Tretinoin 0.05 + OTC grade topical skin lightener agent Hydroquinone 4%.

How to use TriLuma cream

Wash your face with soap and lukewarm water, then pat dry. Refrain from using harsh cleansers, as these can dry out and irritate the skin.

Apply the TriLuma cream to the treatment area. Rub it in well, making sure that the medication stays within the patches of discoloration. Hydroquinone 4% is a bleaching agent that works by preventing melanin production. It affects both abnormally and normally pigmented skin; therefore, application outside of the intended treatment area can result in spots of lighter-than-average pigmentation.

Wash your hands to remove any remaining TriLuma cream. Recommended using the treatment once a day, at least 30 minutes before bedtime. During the day, wear a broad-spectrum SPF 15 sunscreen or moisturizer to prevent hyperpigmented areas from further darkening.

Triluma cream should always be used as instructed by your dermatologist. To use the cream correctly, follow these steps:

  • Apply Triluma cream at night, at least 30 minutes before bedtime;
  • Gently wash your face with a mild cleanser. Don’t use a washcloth to apply the cleanser, just your fingers. Rinse and pat your skin dry;
  • Put a small amount (pea-sized or ½ inch or less) of Triluma cream on your fingertip. Apply a thin coat onto the discolored spot(s). Include about ½ inch of normal skin surrounding the affected area;
  • After you have used the cream for a while, you may find that you need slightly less to do the job;
  • Rub the cream lightly and uniformly into your skin. The cream should become invisible almost at once. If you can still see it, you are using too much;
  • Keep the cream away from the corners of your nose, your mouth, eyes, open wounds. Spread it away from those areas when applying it;
  • Do not use more Triluma cream or apply it more often than recommended by your dermatologist. Too much Triluma cream may irritate your skin and won’t give you faster or better results;
  • Do not cover the treated area with anything after applying the cream;
  • During the use of Triluma cream, you may experience redness, peeling, burning, dryness, itching, or other skin irritation. If your skin gets too irritated, stop using the cream, and let your dermatologist know;
  • Triluma cream may also cause a gradual blue-black darkening of your skin; if this happens, stop using the product immediately and speak to your dermatologist;
  • To help avoid skin dryness, you may use a moisturizer in the morning after you wash your face. You may also use a moisturizer and cosmetics during the day;
  • Use a sunscreen of at least SPF 30 and a wide-brimmed hat over the treated areas. It requires only a small amount of sunlight—not just a sunburn—to worsen melasma;
  • If you do get sunburned, stop using the cream until your skin is healed. After stopping treatment with Triluma cream, continue to protect your skin from sunlight;
  • Only your dermatologist knows which other drugs may be helpful during treatment and will tell you about them if needed. Do not use other medicines unless your dermatologist approves them.

Tri-luma generic cream is indicated for topical application. Strict compliance with the instructions given by your dermatologist will be needed at all times. This cream works best if used at night, and dermatologists generally advise applying it 30 minutes before you go to bed. However, you may wish to wash your face before applying the cream, after which it should be gently patted dry.

Your dermatologist may tell you to apply a small amount (1/2 inch) of cream onto the fingertip, after which it should be thinly coated onto the areas affected by hyperpigmentation. The cream should be gently rubbed into the skin, taking care to ensure that it doesn`t get into the mouth, eyes, or nose. Generally, treatment is continued for a short period of time (8 weeks). After the full treatment period recommended using naturally derived azelaic acid 20% cream to protect, lighten, and regenerate skin upper layer.

Contraindications when using Tri-Luma cream

Tri-Luma should always be used in accordance with the instructions of your dermatologist. Pregnancy and lactation, acute inflammation (including eczema) lesions of the skin (dermatitis, seborrhea, and others), rosacea, skin lesions (wounds, burns, etc), photosensitivity, diseases of the rectum, of liver or kidney, Addison’s disease, asthma, allergic to sulfites, or to any of the components of the cream, hypersensitivity to any component of the cream (discontinue use and consult a dermatologist if you have any of these symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat).

Side effects: redness, peeling, burning, dryness, and itching at the site of application. Discontinue use and notify your dermatologist if you have any of the following side effects: darkening of the treated skin, strong irritation of the skin, the formation of bubbles, dribbling, scaling or crusting, painful burning or swelling of the skin, any type of breathing problems, irritation of your eyes, nose or mouth.

Crema Triluma side effects

If you notice any signs of side effects during application and usage of Triluma cream with main ingredients Fluocinolone / Hydroquinone / Tretinoin, ensure that you notify your dermatologist. The following side effects are widespread: acne, dry skin, erythema, itchy feeling, peeling of the skin, should you notice black-blue discoloration appearing on the skin or severe irritation visit your dermatologist straight away.

Tri Luma Cream Amazon precautions

Triluma crema (Fluocinolone Acetonide/Hydroquinone/Tretinoin) is for topical use only. Do not use abrasive cleaning products, soaps, or other cosmetic products that produce a drying effect or which have high alcohol or astringent levels. Ask your dermatologist about which cleansers are safe for use during Triluma cream applications.

The application of Triluma is also known as the Tri-Luma cream alternative can make it easier for your skin to become sunburned. Therefore, stay out of the sun whenever possible, and protect yourself with long-sleeved clothing, a cap, and other protective clothing if you must go outside. Also recommended to use strong SPF lotions against UV sunlight rays.

Indication: Triluma cream is indicated for the short‐term (up to 8 weeks) treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreens.

Adverse events: In the controlled clinical trials, the most frequently reported events were redness, peeling, burning, dryness, and itching at the site of application.

Warnings/Precautions: Triluma contains sulfites which may cause severe, life‐threatening allergic reactions in people allergic to sulfites. Triluma contains hydroquinone, which may cause a gradual blue‐black darkening of the skin. If you are pregnant, nursing or trying to become pregnant you should not use Triluma. Safety and efficacy have not been established in individuals with darker skin. Reversible HPA axis (adrenal function) suppression may result from exposure to the topical fluocinolone, so discontinue use if signs and symptoms of this condition occur. Avoid products that may dry or irritate the skin, such as abrasive cleansers, scrubs, or skin‐peeling agents. Exposure to sunlight, sunlamps, or UV light and extreme heat, wind, or cold should be avoided. If exposure cannot be avoided, sunscreen products [SPF 30 or more] and protective apparel should be used.

Tri luma cream where to buy online Canada? If you live in Canada you can order Tri Luma to your home via okdermo skincare store at this page. Tri luma cream price is the lowest among other Canada Pharmacies. Triluma cream order at okdermo and you will never be disappointed, our free-reshipping policy and unbeatable prices coupled with unprecedented and fast support are available 24/7 for You!

Creams to get rid of freckles

Freckles appear as small spots of skin discoloration, often dotting your face, chest, shoulders, arms, and legs. Freckles may detract from the flawless, even skin tone you want and may even be an important indicator of skin cancer risks. Several skin care creams like Triluma crema from Galderma can help you fade and lighten freckles. 2% Hydroquinone component of this cream works by inhibiting skin pigment production and bleaching the skin cells. It’s effective for fading hyperpigmented skin conditions like freckles.

Once faded, the results may last for up to one year before you need additional hydroquinone treatments. Numerous creams in the store contain hydroquinone at concentrations of approximately 2 percent to 5 percent and will effectively lighten your freckles within two months. Everyone has to follow the total sun avoidance program during the treatment and always consult their dermatologist prior to using Tri luma cream amazon. You can always buy Tri-Luma cream online via the website. Tri-Luma cream can be bought online OTC via amazon and Paypal on the OKDERMO Skincare store.

Related resources/references:

  1. FAQ hydroquinone topical cream
  2. How to use hydroquinone HQ cream
  3. What is melasma and hyperpigmentation
  4. About hydroquinone topical
  5. Hydroquinone topical side effects
  6. Hydroquinone cream during pregnancy
  7. Hydroquinone with sunscreen

Additional Information


  • Hydroquinone 2%
  • Tretinoin 0.025%
  • Fluocinolone acetonide 0.01%

Other ingredients: butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol.