Tri-Luma® Cream

Hydroquinone 2% / 4% + Tretinoin 0.012% / 0.05% + Fluocinolone 0.01%

4.44 out of 5

(43 customer reviews)

From USD $30.00 (EUR €25.80)

✓ Potent melasma remover with 3 active ingredients

✓ A powerful depigmenting agent to help lighten the skin

✓ Reducing inflammation – helps heal the skin

✓ A vitamin-A derivative which protects & increasing exfoliation

✓ A short‐term (up to 8 weeks) treatment of severe melasma

✓ Reputable manufacturers – Galderma and KLM Pharma

Brand name: Lumiquin, Lumacip Plus, Refaquin, Retrieve
Items:3 - 5 5%
Items:6 - 9 10%
Items:10 + 15%


What is Tri-Luma® cream?

Tri-Luma cream with active substances fluocinolone, hydroquinone, and tretinoin is a clinical strength high-quality cream for skin hyperpigmentation removal. Tri-Luma is a triple combination cream which works for melasma, skin hyperpigmentation, dark spots, freckles, dark discolorations. It lightens the skin, reducing inflammation, and increasing exfoliation. Tri-Luma should always be used in conjunction with sun-avoidance measures, like using strong sunscreens and wearing protective clothing, it dramatically improves the appearance of melasma. It is not recommended to use Tri-Luma cream longer than 5 months in a row. Tri-Luma RD should always be used in accordance with the instructions of your dermatologist.

Melasma is a skin condition that affects the appearance of the facial skin, causing brown patches to appear. These are due to excess melanin production (the pigment that gives the skin its color). It could be related to pregnancy or pills which have been taken by the affected person, sunlight is also believed to trigger it. Melasma also is known as chronic skin hyperpigmentation characterized by symmetrical, blotchy, brownish facial pigmentation. Melasma/chloasma is caused by the overproduction of melanin by the pigment-producing cells melanocytes.

Tri-Luma cream has two versions: with low-strength components – Hydroquinone 2%/Tretinoin 0.025%/Fluocinolone Acetonide 0.01%  and a version with high-strength components: Hydroquinone 4%/Tretinoin 0.05%/Fluocinolone 0.01% active ingredients that is designed for topical treatment of stubborn/severe hyperpigmentation cases and skin color issues. An anti-melasma cream with 3 active ingredients, uniquely combined and more effective than solutions containing only two of the ingredients. Manufactured by reputable Galderma, a unique triple-combination topical therapy for the short-term (8-week) treatment of the dark spots associated with moderate-to-severe facial melasma:

  • Hydroquinone 4% – skin depigmenting agent flawlessly blocks the melanin, and evens skin tone;
  • Tretinoin 0.05% – synthetic vitamin A, it renews the skin;
  • Fluocinolone acetonide 0.01% – anti-inflammatory agent, helps to heal the skin, reducing the inflammation.

Hydroquinone 4%: The production of melanin is controlled by the enzyme tyrosine, which is found in the melanosomes of melanocytes. Hydroquinone 4% in Triluma cream is a tyrosinase inhibitor that works by blocking the action of tyrosinase, which inhibits the formation of melanin by melanocytes. It also increases the breakdown of melanosomes that contain melanin. As the amount of melanin produced decreases the darkened skin gradually lightens to match normal skin color.

Tretinoin 0.05%: Tretinoin in cream is an active metabolite of Vitamin A and is a keratolytic medicated retinol that works by binding to specific retinoic acid receptors in the nucleus of skin cells and affects the way skin cells behave, which regulates cell growth and differentiation; it also has anti-inflammatory properties. Tretinoin 0.05% is thought to act by enhancing skin epithelial cell proliferation and accelerating epithelial differentiation; it also blocks the hardening processes of the outer skin layer (keratinization and cornification) and increases the shedding of old hardened skin cells, while at the same time promoting the growth of new skin cells. The combined effect of these actions is to speed up skin cell turnover which has the effect of lightening the skin.

Fluocinolone Acetonide 0.01%: Triluma cream also contains the synthetic mild anti-inflammatory component, which is a medium potency anti-inflammatory that is often used for topical application as it concentrates in the skin but does not enter the blood circulation and, therefore, has the minimal systemic effect. Fluocinolone acetonide 0.01% in the cream works by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes; and also narrows and constricts causes blood vessels that have become dilated (widened) and leaky allowing other inflammatory cells into the skin to escalate the inflammatory response. The anti-inflammatory actions of Fluocinolone in Triluma cream reduce the risk of developing contact dermatitis that may be caused by other Triluma cream components like hydroquinone and tretinoin. This combination of strong ingredients for the treatment of melasma has been found to provide better improvement than treatment with a single-component cream like plane hydroquinone or tretinoin exfoliator.

Other ingredients (excipients): butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, Methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol.

Tri Luma cream key ingredients

  • Fluocinolone 0.01 is classified as a mild anti-inflammatory component and it is said to work by reducing inflammation on the skin.
  • Hydroquinone 4 also called dihydroxybenzene is a topical skin brightening agent that works by inhibiting the action of an enzyme called tyrosinase. This, in turn, helps to prevent the formation of melanin and contributes to skin depigmentation, allowing for the melanin patches to become brighter.
  • Tretinoin 0.05 also called all-trans retinoic acid – is a form of vitamin A which plays a key role in cellular growth and regeneration. Topical application helps to rejuvenate and revitalize the surface of the skin.

How Tri-Luma Hydroquinone 4 + Tretinoin 0.05 cream works

Tri-Luma cream provides fast results for skin hyperpigmentation treatment even after the first 6-8 weeks of application, approved by FDA, and contains 3 active ingredients. The term hyperpigmentation refers to the dark, discolored patches of skin that occur when melanin is overproduced. Reasons for this overproduction include sun exposure, skin damage, hormones, and certain medications. The condition is typically harmless, though its appearance on prominent areas of the body, such as the face, can affect your self-esteem. Fortunately, there are several over-the-counter fade creams intended for home use. At-home creams and lotions lighten dark spots over time and offer a less-expensive, less-invasive alternative to professional treatments. Consult a professional to determine one that is suitable for you.

Tri-Luma cream works by decreasing melanin production in skin cells – melanocytes with the help of hydroquinone 4% salts, tretinoin 0.05% component help to shred and pill an older and darker skin part, fluocinolone acetonide 0.01% protect skin from inflammations.

Melasma condition is spread through persons who have a genetic predisposition and may be triggered by various factors including sun exposure, pregnancy, hormone treatments, some toiletries, and low thyroid hormone conditions. TriLuma cream is a powerful 3-way combination treatment that lightens the skin and reduces the risk of dermatitis, inflammation of the skin that can be associated with using skin lighteners alone to treat melasma. Tri-luma cream contains 3 different ingredients which are anti-inflammatory component Fluocinolone 0.01 + keratolytic, mild peel, and skin repair agent  Tretinoin 0.05 + OTC grade topical skin lightener agent Hydroquinone 4%.

How to use TriLuma cream

Wash your face with soap and lukewarm water, then pat dry. Refrain from using harsh cleansers, as these can dry out and irritate the skin.

Apply the TriLuma cream to the treatment area. Rub it in well, making sure that the medication stays within the patches of discoloration. Hydroquinone 4% is a bleaching agent that works by preventing melanin production. It affects both abnormally and normally pigmented skin; therefore, application outside of the intended treatment area can result in spots of lighter-than-average pigmentation.

Wash your hands to remove any remaining TriLuma cream. Recommended using the treatment once a day, at least 30 minutes before bedtime. During the day, wear a broad-spectrum SPF 15 sunscreen or moisturizer to prevent hyperpigmented areas from further darkening.

Triluma cream should always be used as instructed by your dermatologist. To use the cream correctly, follow these steps:

  • Apply Triluma cream at night, at least 30 minutes before bedtime;
  • Gently wash your face with a mild cleanser. Don’t use a washcloth to apply the cleanser, just your fingers. Rinse and pat your skin dry;
  • Put a small amount (pea-sized or ½ inch or less) of Triluma cream on your fingertip. Apply a thin coat onto the discolored spot(s). Include about ½ inch of normal skin surrounding the affected area;
  • After you have used the cream for a while, you may find that you need slightly less to do the job;
  • Rub the cream lightly and uniformly into your skin. The cream should become invisible almost at once. If you can still see it, you are using too much;
  • Keep the cream away from the corners of your nose, your mouth, eyes, open wounds. Spread it away from those areas when applying it;
  • Do not use more Triluma cream or apply it more often than recommended by your dermatologist. Too much Triluma cream may irritate your skin and won’t give you faster or better results;
  • Do not cover the treated area with anything after applying the cream;
  • During the use of Triluma cream, you may experience redness, peeling, burning, dryness, itching, or other skin irritation. If your skin gets too irritated, stop using the cream, and let your dermatologist know;
  • Triluma cream may also cause a gradual blue-black darkening of your skin; if this happens, stop using the product immediately and speak to your dermatologist;
  • To help avoid skin dryness, you may use a moisturizer in the morning after you wash your face. You may also use a moisturizer and cosmetics during the day;
  • Use a sunscreen of at least SPF 30 and a wide-brimmed hat over the treated areas. It requires only a small amount of sunlight—not just a sunburn—to worsen melasma;
  • If you do get sunburned, stop using the cream until your skin is healed. After stopping treatment with Triluma cream, continue to protect your skin from sunlight;
  • Only your dermatologist knows which other drugs may be helpful during treatment and will tell you about them if needed. Do not use other medicines unless your dermatologist approves them.

Tri-luma generic cream is indicated for topical application. Strict compliance with the instructions given by your dermatologist will be needed at all times. This cream works best if used at night, and dermatologists generally advise applying it 30 minutes before you go to bed. However, you may wish to wash your face before applying the cream, after which it should be gently patted dry.

Your dermatologist may tell you to apply a small amount (1/2 inch) of cream onto the fingertip, after which it should be thinly coated onto the areas affected by hyperpigmentation. The cream should be gently rubbed into the skin, taking care to ensure that it doesn`t get into the mouth, eyes, or nose. Generally, treatment is continued for a short period of time (8 weeks). After the full treatment period recommended using naturally derived azelaic acid 20% cream to protect, lighten, and regenerate skin upper layer.

Contraindications when using Tri-Luma cream

Tri-Luma should always be used in accordance with the instructions of your dermatologist. Pregnancy and lactation, acute inflammation (including eczema) lesions of the skin (dermatitis, seborrhea, and others), rosacea, skin lesions (wounds, burns, etc), photosensitivity, diseases of the rectum, of liver or kidney, Addison’s disease, asthma, allergic to sulfites, or to any of the components of the cream, hypersensitivity to any component of the cream (discontinue use and consult a dermatologist if you have any of these symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat).

Side effects: redness, peeling, burning, dryness, and itching at the site of application. Discontinue use and notify your dermatologist if you have any of the following side effects: darkening of the treated skin, strong irritation of the skin, the formation of bubbles, dribbling, scaling or crusting, painful burning or swelling of the skin, any type of breathing problems, irritation of your eyes, nose or mouth.

Crema Triluma side effects

If you notice any signs of side effects during application and usage of Triluma cream with main ingredients Fluocinolone / Hydroquinone / Tretinoin, ensure that you notify your dermatologist. The following side effects are widespread: acne, dry skin, erythema, itchy feeling, peeling of the skin, should you notice black-blue discoloration appearing on the skin or severe irritation visit your dermatologist straight away.

Tri Luma cream precautions

Triluma crema (Fluocinolone Acetonide/Hydroquinone/Tretinoin) is for topical use only. Do not use abrasive cleaning products, soaps, or other cosmetic products that produce a drying effect or which have high alcohol or astringent levels. Ask your dermatologist about which cleansers are safe for use during Triluma cream applications.

Application of Triluma is also known as Tri-Luma cream alternative can make it easier for your skin to become sunburned. Therefore, stay out of the sun whenever possible, and protect yourself with long-sleeved clothing, a cap, and other protective clothing if you must go outside. Also recommended to use strong SPF lotions against UV sunlight rays.

Indication: Triluma cream is indicated for the short‐term (up to 8 weeks) treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreens.

Adverse events: In the controlled clinical trials, the most frequently reported events were redness, peeling, burning, dryness, and itching at the site of application.

Warnings/Precautions: Triluma contains sulfites which may cause severe, life‐threatening allergic reactions in people allergic to sulfites. Triluma contains hydroquinone, which may cause a gradual blue‐black darkening of the skin. If you are pregnant, nursing or trying to become pregnant you should not use Triluma. Safety and efficacy have not been established in individuals with darker skin. Reversible HPA axis (adrenal function) suppression may result from exposure to the topical fluocinolone, so discontinue use if signs and symptoms of this condition occur. Avoid products that may dry or irritate the skin, such as abrasive cleansers, scrubs, or skin‐peeling agents. Exposure to sunlight, sunlamps, or UV light and extreme heat, wind, or cold should be avoided. If exposure cannot be avoided, sunscreen products [SPF 30 or more] and protective apparel should be used.

Creams to get rid of freckles

Freckles appear as small spots of skin discoloration, often dotting your face, chest, shoulders, arms, and legs. Freckles may detract from the flawless, even skin tone you want and may even be an important indicator of skin cancer risks. Several skin care creams like Triluma crema from Galderma can help you fade and lighten freckles. 2% Hydroquinone component of this cream works by inhibiting skin pigment production and bleaching the skin cells. It’s effective for fading hyperpigmented skin conditions like freckles.

Once faded, the results may last for up to one year before you need additional hydroquinone treatments. Numerous creams in the store contain hydroquinone at concentrations of approximately 2 percent to 5 percent and will effectively lighten your freckles within two months. Everyone has to follow the total sun avoidance program during the treatment and always consult your dermatologist prior to using Tri luma cream amazon. You can always buy Tri-Luma cream online via the website. Tri-Luma cream can be bought online OTC via amazon and Paypal on the OKDERMO Skincare store.

Related resources/references:

  1. FAQ hydroquinone topical cream
  2. How to use hydroquinone HQ cream
  3. What is melasma and hyperpigmentation
  4. About hydroquinone topical
  5. Hydroquinone topical side effects
  6. Hydroquinone cream during pregnancy
  7. Hydroquinone with sunscreen



Galderma S.A. is a pharmaceutical subsidiary specializing in the research, development and marketing of dermatological treatments. The company became a wholly owned subsidiary of Nestlé in 2014. Galderma provides a range of products used to treat acne, rosacea, psoriasis and other steroid-responsive dermatoses (SRD), onychomycosis (fungal nail infections), pigmentary disorders, skin cancer and skin senescence. Galderma’s products sell in more than 70 countries. Galderma is the medical solutions brand within Nestlé Skin Health. Given the important role our skin plays in our daily lives, we focus on science-based solutions that will enhance the quality of people's lives. The Code of Ethics is an explicit declaration of adherence to the highest ethical standards in our work. It states that it is the responsibility of every employee to “do the right thing, the right way” to ensure the highest standards of integrity. It means that when we create value for our company and its stakeholders, such as the people and communities we serve, we should do so by acting in an ethical and socially responsible way. The Code reflects the values and behavior that have strongly contributed to making us successful over the years. Galderma provides both prescription drugs and aesthetic solutions, treating compromised skin, enhancing healthy skin, and providing solutions for aging skin. For over 35 years, Galderma has partnered with healthcare professionals and academia across the globe to find innovative solutions to skin issues and deliver safe and effective treatments to meet the skin health needs of people throughout their lifetimes. Galderma provides prescription drugs and aesthetic solutions, going beyond treating skin problems to enhance healthy skin, treat compromised skin and rejuvenate aging skin. Galderma also offers over-the-counter products, providing consumers with the solutions they need to maintain healthy skin throughout their lives. Today, dermatology is receiving a growing amount of recognition and attention. As we are living longer, caring for our skin as we age is also becoming increasingly important. Galderma is spearheading this change in the world’s outlook on skin health. As a focused dermatology company right from the start, Galderma is committed to the healthcare community, providing education and training programs as well as ongoing support to healthcare professionals throughout their career, to enable them to remain at the forefront of their field. Today, Galderma's product portfolio is available in more than 100 countries, offering treatment for a range of dermatological conditions. In the United States, our portfolio includes aesthetic solutions as well as treatments for acne, rosacea, steroid-responsive dermatoses and melasma, and over-the-counter solutions for consumers.

Glasier Wellness

We at Glasier Wellness Inc. believe in presenting to our client’s optimum quality medicines at the most reasonable prices. The unmatched quality of the offered products is maintained through a quality assurance survey conducted at our vendor state-of-the-art and well-equipped in-house quality testing unit. Owing to the efficiency and sincere efforts of our team members, we are able to deliver our offered products within the requested frame of time. To offer a broad assortment of medicines, we have a long list of vendor base across the market. We have selected our vendors on the basis of their market status and quality assured products. Our vendors are fully aware of the quality and client-focused approach to our organization so they are providing the products in compliance with it. These products are processed through a number of quality checks by our vendors, in pursuit to provide the best possible quality to the customers. We are a popular organization in this domain, involved in trading and wholesaling a wide spectrum of medicines for our valued clients. Offered products are composed by taking the best quality ingredients as per the parameters laid by the industry. We are offering all the products in various packaging options. Apart from this, our clients can avail the offered products from us at the nominal market price.
Glasier Wellness

KLM Labs

The KLM Lab (P) Ltd conceptualized in the year 2006 and since its inception has grown in leaps and bounds providing quality. The company initiated by business professionals with vast experience in the pharmaceutical sector. Our business philosophy has three elements - raison d'être, mission and beliefs. This business philosophy expresses the companies of aiming to contribute to the health of people around the country through the provision of highly effective and trustworthy pharmaceutical product, while continuously increasing the trust value. We support healthy living for people. Moreover, we believe that all stories should have honesty and truth in them, as honesty prospers in every condition of life and we trust a no-lies policy. We believe to grow beyond its horizon of goals and innovate continuously, in order to become a hallmark of a dynamic organization, responding to its market needs. To offer integrated, best quality pharmaceutical and cosmeceutical products, enabling us to seat among Top rank companies, and to be a reliable partner in our sphere of work through valued, compelling relationships. We believe to surpass customer expectation. Customer satisfaction is seen as a key differentiator and has become a key element of our business strategy. Quality is our obsession with timeless perfection. Quality assurance demands a degree of detail in order to be fully implemented at every step. Our goal is to exceed customer expectations in a measurable way. We believe that the quality, safety and efficacy of any product is directly proportional to the amount of care and attention that is used in obtaining quality ingredients, and during its manufacture, with proper good manufacturing practices (GMP) and quality control processes. GMP's are quality standards requiring the control of production activities, raw material quality, compliance management for products. Our success has been, and will continue to be with excellent quality products, we carter to. Our obsession for quality at every step along the way!

Additional Information


  • Hydroquinone 2%
  • Tretinoin 0.025%
  • Fluocinolone acetonide 0.01%

Other ingredients: butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol.