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Tri-Luma® Cream for Hyperpigmentation

Hydroquinone 2% / 4% + Tretinoin 0.012% / 0.05% + Fluocinolone 0.01%

(44 customer reviews)

From USD $35.00

Discover the transformative power of Tri-Luma® Cream, a unique triple-combination therapy specifically designed to combat hyperpigmentation. This high-quality topical treatment:

  • Effectively lightens dark spots and discolorations caused by conditions such as melasma and freckles, thanks to its active ingredient Hydroquinone
  • Promotes skin renewal and exfoliation with Tretinoin, a synthetic form of Vitamin A that accelerates skin cell growth
  • Reduces inflammation and potential skin irritation with Fluocinolone Acetonide, a medium-potency anti-inflammatory agent
Size: 15g / 0.53oz, 20g / 0.7oz
Brand name: Lumiquin, Lumacip Plus, Refaquin, Retrieve
Title Range Discount
Items: 2 - 4 5%
Items: 5 - 8 10%
Items: 9 + 15%


What is Tri-Luma® Cream?

Tri-Luma® Cream is a product of Galderma, a reputable pharmaceutical company known for its high-quality skincare products. It’s designed for short-term use and should always be used in conjunction with sun-avoidance measures for optimal results.

Available for purchase online from OKDERMO, this cream is accessible to customers in the USA, UK, Canada, Mexico, and more. With competitive pricing and reliable shipping, OKDERMO ensures that your journey to healthier, more radiant skin is just a click away. Experience the benefits of Tri-Luma® Cream and start your journey to a more even-toned, radiant complexion today!

Tri-Luma® Cream is a unique, high-quality topical treatment designed to combat skin hyperpigmentation. This triple-combination therapy is specifically formulated to address conditions such as melasma, dark spots, freckles, and other dark discolorations on the skin. The cream works by lightening the skin, reducing inflammation, and increasing exfoliation.

Tri-Luma Cream is a product of Galderma, a reputable pharmaceutical company known for its high-quality skincare products. The cream is designed for short-term use, typically not exceeding five months in a row, and should always be used in conjunction with
sun-avoidance measures, such as using strong sunscreens and wearing protective clothing.

The effectiveness of Tri-Luma Cream can be seen in the before and after pictures in the product gallery. These pictures show a noticeable reduction in hyperpigmentation, with the skin appearing more even-toned and radiant.

Testimonials from users also attest to the effectiveness of the product. Many users have reported seeing improvements in their skin condition within a few weeks of using the cream.

Active Ingredients of Tri Luma Cream

Tri-Luma Cream is composed of three active ingredients: Hydroquinone, Tretinoin, and Fluocinolone Acetonide. Each of these components plays a crucial role in the effectiveness of the cream.

  • Hydroquinone 4%: This is a skin depigmenting agent that flawlessly blocks melanin production, evening out skin tone. It inhibits the enzyme tyrosinase, which controls melanin production, thus reducing the formation of melanin by melanocytes. As melanin production decreases, the darkened skin gradually lightens to match the normal skin color.
  • Tretinoin 0.05%: Tretinoin is a synthetic form of Vitamin A that renews the skin. It binds to specific retinoic acid receptors in the nucleus of skin cells, affecting how these cells behave. This regulates cell growth and differentiation and also has anti-inflammatory properties. Tretinoin accelerates skin epithelial cell proliferation and epithelial differentiation, promoting the growth of new skin cells and lightening the skin.
  • Fluocinolone Acetonide 0.01%: This is a medium potency anti-inflammatory agent that concentrates in the skin but does not enter the blood circulation, thereby minimizing systemic effects. Fluocinolone Acetonide reduces the risk of developing contact dermatitis that may be caused by other components of the cream, like hydroquinone and tretinoin.

Benefits of Tri-Luma Cream

Tri-Luma® Cream offers several benefits, making it a preferred choice for treating hyperpigmentation. These benefits include:

  • Treating Dark Spots: The cream is effective in treating dark spots caused by melasma, a skin condition that causes brown patches to appear due to excess melanin production.
  • Exfoliating the Skin: Tretinoin, one of the active ingredients in Tri-Luma® Cream, promotes the shedding of old hardened skin cells and the growth of new ones, thereby exfoliating the skin.
  • Anti-Inflammatory Properties: The Fluocinolone Acetonide in Tri-Luma® Cream has anti-inflammatory properties that help to heal the skin and reduce inflammation.

How to Use Tri-Luma Cream

Using Tri-Luma® Cream properly is crucial to achieving the desired results. Here is a step-by-step guide on how to apply the cream:

  • Wash your face gently with a mild cleanser and warm water, then pat your skin dry.
  • Apply a small amount (pea-sized drop) of cream to your clean, dry face.
  • Always apply the cream about 30 minutes before bedtime.
  • Rub the cream gently into the skin, ensuring to spread it evenly.
  • Do not overuse the cream as this will not result in better results.
  • Ensure to rub in fully so your skin absorbs the cream.
  • Avoid applying the cream to the corners of your nose, mouth, eyes, or open wounds as it may cause irritation.

Remember, it’s essential to use the cream in conjunction with sun-avoidance measures. This includes using sunscreen with a high SPF, wearing protective clothing, and avoiding direct sunlight exposure, especially between 10 AM and 2 PM when the sun’s rays are most intense.

Where to Buy Tri-Luma® Cream

Tri-Luma® Cream is available for purchase online from various platforms. One reliable source is OKDERMO, an online skincare and beauty store that offers a wide range of skincare products. They provide shipping to various countries, including the USA, UK, Canada, and Mexico.

Whether you’re in Canada and looking to buy Tri-Luma Cream online, or you’re in Mexico and want to order Tri-Luma® Cream online, OKDERMO has got you covered. They offer a seamless and secure online shopping experience, ensuring that your product reaches you in the best condition.

Tri-Luma Cream Price

The price of Tri-Luma® Cream can vary depending on the platform you choose to purchase from. However, OKDERMO offers competitive pricing for this product. It’s always advisable to compare prices on different online platforms to ensure you’re getting the best price on Tri-Luma® Cream.

Tri-Luma® Cream Side Effects

While Tri-Luma® Cream is generally safe to use, some users may experience side effects. These can include skin redness, peeling, dryness, burning, or itching. If these symptoms persist or worsen, it’s advisable to stop using the product and consult a healthcare professional.

In rare cases, the cream may cause a blue-black darkening of the skin. If this occurs, stop using the cream immediately and seek medical attention.

Remember, it’s always best to consult with a healthcare professional before starting any new skincare regimen.

In conclusion, Tri-Luma® Cream is a potent solution for hyperpigmentation. Its unique combination of active ingredients works synergistically to lighten the skin, reduce inflammation, and promote skin renewal. Whether you’re dealing with melasma, freckles, or other forms of hyperpigmentation, Tri-Luma® Cream offers a promising solution.

Resources (updated on May 18, 2023)

Additional Information


  • Hydroquinone 2%
  • Tretinoin 0.025%
  • Fluocinolone acetonide 0.01%

Other ingredients: butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, glyceryl stearate, magnesium aluminum silicate, methyl gluceth-10, methylparaben, PEG-100 stearate, propylparaben, purified water, sodium metabisulfite, stearic acid, and stearyl alcohol.

44 reviews for Tri-Luma® Cream for Hyperpigmentation

  1. Tyrell Mosley

    I have seem amazing results in just a week when I first started using it.

  2. Jaron Martin

    It’s working !!! It is absolutely worth it!!

  3. Rylee C

    I’ve been self-conscious about this for far too long.

  4. Jeramiah P.

    I was prescribed this by my dermatologist because I was developing brownish skin on my upper lip during the summer when I have more sun exposure. I have been on the same birth control for 12 years and never had an issue until now. I tried a bleaching cream from Amazon that didn’t do much. My insurance is known to be pretty good, but because this is a cosmetic issue it is not covered. I spent about $60 on this tube of TriLuma cream via okdermo. The price is reasonable to cheap, but I only need a dab at night and after a week of use my issue has been cleared! I use SPF 100 sunscreen on my upper lip and a dot of this cream at night and I am all set. It is worth it for me.

  5. Annabella Franco

    Tri Luma is the only product out there that worked/works for me and that has made a huge difference in my life.

  6. Killian Reid


  7. Andre Mcclure

    I am not a blogger at all but I feel it is my duty to write this review because I know there are countless other women who suffer from persistent melasma like myself. It has been almost two years that I have been fighting with ugly dark spots on my cheeks and upper lip due to contraceptions which I quit using after finding out what I thought to be harmless sunspots are actually a nightmarish side effect of birth control pills. After several visits to different doctors’ offices and a ton of useless over-the-counter drugs my last and and most understanding dermatologist prescribed Tri-luma, even though this is not a cure, in less than ten days my spots are visibly lighter and barely noticeable. It works!

  8. Angeline Harris

    As others have noted, I too have tried many different products and procedures to reduce or eliminate my melasma. It was deep in nature and over my forehead, cheeks and upper lip. Makeup barely helped to mask the melasma. I ordered Triluma online through an okdermo and have been using it morning and night for the past month. All I can say is hallelujah!! Although the melasma isn’t completely gone is it a good 80% lightened on my cheeks & upper lip. My forehead has lightened, but not quite as much. Maybe 60 to 70% lighter. I wear a non-chemical sunscreen (zinc oxide type), and generally wear a hat when out in the sun.

  9. Santiago Hardy

    Had so much dark spots and my doctor prescribed this medication best thing ever work in less than a Week am happy skin is flawless now

  10. Carlie

    Tri-luma works great. Have been using it for post inflammatory hyperpigmentation. Only thing is that just as soon as you stop using it the dark areas come back. You can maintain the result with an azelaic acid, kojic acid, glycolic, etc.

  11. Dominic L.

    This product is amazing!

  12. Lexi

    I have been suffering from a bad case of melasma on my upper lip and both cheeks for about 6 years. And I say suffering because anyone who has had melasma can understand how it makes you feel and the damage it can do to your self esteem. I did the obagi system 3 years ago and it helped but never completely got rid of it. I then tried other creams without hydroquinone and none worked and I went from cheap to expensive. I went to an esthetician and she recommended I got to my doctor and try Tri Luma before trying lasers as they could do more damage (I’m hispanic with olive skin). I started the Tri Luma reluctantly and I cant believe how fast this works! My family has made comments how much better my skin looks already. My mom said it looked like I was trying to cover bruises with makeup and now she can’t see the melasma under my makeup! I am not clear but its much much lighter in about 2 weeks.

  13. Keagan Bridges

    I have very mild sun damage and my skin was just starting to look dull and tired. I take care of my skin, exfoliate regularly and moisturize. But I am in my early 40’s and just didn’t seem to have a “fresh” looking complexion anymore. HELLO TRI-LUMA! I just started using this product after my doctor suggested it. I don’t have enough damage or problems to warrant peels or more intense treatment options so Tri-Luma was his recommendation. And I must say, just after a few treatments, my face looks AMAZING. I am so thankful something like this exists. I highly recommend. And the cost is nothing compared to what you could spend on facials, peels and random expensive beauty creams. Who needs $500 LaMer when $100 Tri-Luma exists? Duh.

  14. Laura Mooney

    Negative reviews seem to be people that weren’t given proper instructions (or ignored the instruction given) to say out of the sun or use strong protection when using.

  15. Julien G.

    I’ve struggled with melasma for a long time. I was so tired of my extensive make up routine and feeling embarrassed to be bare faced in front of my boyfriend, my confidence was shot. After researching many products to see if there was any hope I stumbled upon this gem of a page. Tri luma!! I can’t praise this product enough, it’s changed my life. I went out in public with no make up on for the first time in years. It took about a month to see drastic results. Don’t be discouraged if you don’t see results in one week, keep diligent with the routine and it will work. So worth the money.

  16. Justine Mcdowell

    I have never written a review for a product before, and I fall under the category of people that had previously tried EVERY single other method out there for melasma, seeing hydroquinone products as a last last last resort. I’ve spent a good $300 bucks trying to rid myself of the melasma mustache that I received from a combo of birth control pills and sun exposure. After consulting with a dermatologist, the preconceived notions I had against hydroquinone got cleared up, and I started taking Tri-Luma. It’s been SEVEN DAYS, and my melasma is almost gone. I could not be more thankful.

  17. Cohen

    Very satisfied and happy with the result. As long as you put sunscreen, you’re fine.

  18. Yolanda R.

    Pretty good results, thank you!

  19. Audrina Mcdowell

    Thank you for finally bringing it back!

  20. Christopher I

    I’ve had melasma since 2007. I notice a small brown patch on my right side of my cheek and didn’t think nothing of it till someone else noticed that it was there and was spreading. I think I was in denial until I seen it on my forehead and then on my other cheek and also upper lip. I spent a lot of money, time, and a lot of disappoint on many products. Until 2 weeks ago when my dermatologist suggested that I try tri-luma. I was at the point to where I was so discouraged and depressed I was at my point that I just didn’t even want to try. I thought to myself. I’ll try one more item and only cuz I looked up the reviews on tri-luma and believe me it’s not cheap. But I will admit it is out of this world amazing. And it really works.

  21. Raiden Arellano

    All I can say is Hallelujah!!!!

  22. Jase F

    I’ve tried everything. I’ve tried Rodin and Fields, I’ve tried very expensive chemical peels, I’ve tried regular hydroquinone. This is the only thing that has given me any results. I’ve been using it for a few weeks and I’ve already seen a difference. It’s been especially effective on the melasma on my fore head, although it is also made my melasma mustache considerably lighter. You have to go to the doctor to have it prescribed, and it is very expensive if buy by rx.

  23. Kane L.


  24. Aryana Sanford

    I’m so amazed Saw a huge difference in 4 days Today is day 16 and my cheeks are CLEAR.

  25. Zayne

    Some people have commented that their skin actually has gotten darker a few days after beginning to apply Tri-Luma. The same happened to me, but I realized that my problem was that after I applied Tri-Luma before bed time, I would read for about one hour with a light directly on my face. The chemicals in the cream were reacting to the light. I stopped the treatment for a few days. When again I started applying Tri-Luma, I immediately turned off the lights and went to sleep. That worked! After two months I now have about 90% clearer skin (I am olive skinned).

  26. Kinley Barnett

    God is so good, I got my skin back.

  27. Kenya J.

    This Cream will only work when you apply it. Once you stop, Hyperpigmentation reappears even faster than it disappeared. Means that you have to use a skin lightening alterantives like kojic/azelaic/glycolic etc acids to maintain the results forever after TriLuma treatment.

  28. Branden Byrd

    Is this product a few years ago then the company stopped making it was very disappointed because the results are awesome want to see my derm she said the pharmaceutical company is making triluma again and 4 days later my face is completely clear I was advised to continue to wear my sunscreen and hats

  29. Braeden Spears

    I am happy that its available again!

  30. Jason W.

    After struggling with melasma under my eyes from birth control and sun exposure I tried many different products and none even seemed to make any difference. Within a week and a half of use Triluma has reduced the darkness by probably 75%. Use sparingly and follow instructions, more isn’t better with this product. A small amount does the trick.

  31. Holly Fleming

    I’m very disappointed, my dermatologist prescribed Triluma. After the first tube which was I got from the dermatologist, the brown spot became darker. I went back to the dermatologist and he said that I should continue using the product. I bought the second tube and the spots fade away very slightly, but as soon as I stop using it the spot just reappear.

  32. Marjo

    I began to see results within two weeks. The dark patches and mottled appearance of my skin has almost completely disappeared. I have received several compliments on how clear my skin looks. A little goes long way so don’t use too much. The results are fantastic! The price is brllliant, youve never find cheaper triluma analogs with then in okdermo!! Thanks to you!

  33. Monserrat Garcia

    My advice – get off birth control immediately, practice religious sun care, and don’t be afraid of hydroquinone 🙂

  34. Luke Cooper

    So happy to see it available again with okdermo!

  35. Ritah N.

    Been using this product for almost a month and I can say it really is clearing up my melasma, lighten up scars. I really can’t wait to see how my skin will look by December!

  36. Kaylen Rowe

    I never had any skin problem until my first pregnancy at 27. I was not make up or any other cream user, but had the very clean face. Everyone, stops me and ask me what kind of make I use. But this became story after I gave birth to my first child. I have been struggling with it one day Dr. Simpson prescribed this cream for me. With in few days , the very brown spot on my nose went away. Good is so good!!!! Ladies with same problem, please give it try and hope you won’t regret. May glory be to the Mighty LORD!

  37. Mommy Love

    Wow thank you! One fifth the price of tri luma , works exactly the same!

  38. Ella Murillo

    this is a product that TRULY WORKS, I’m 58 years young and I have a a few dark spots on my cheek. After 2 weeks, all 3 spots were lighter, after 3 weeks they are nearly not noticeable. I’m on my 4th week and I couldn’t love this product any more. One expensive tube will last several months and is worth every penny of it.

  39. Kailee H

    It’s hard to believe that there is a product out there that actually works but this is it.

  40. John

    Within 2 weeks there was a noticeable difference. By 4 it had all gone. It was on the tip of my nose so very noticeable. I stopped using after 6 weeks as directed and noticed it coming back by a week later. I’ve started using again and disappeared within a few days. VERY happy!

  41. valeria (verified owner)

    I had very bad melasma for 3-4 years now due to hormonal imbalance. I always had a fantastic skin and I was totally frustrated and mortified. It looked to me I had aged 20 years in a couple of months. I tried Hydroquinone alone, Retin A alone, many other bleaching products, and this is the only one that made a very marked difference in basically 1-2 weeks. I cannot believe it, because I thought if Hydroquinone and Retin A don’t do much, why a combination of them would work…but it actually does. Yes, I am aware that results will last as far as you keep using it. Melasma is often a chronic condition, sadly, unless at some point the hormones get to another balance that makes it go away. But it’s still excellent and absolutely worth the money. I now can go around without any make up and the skin will look just OK, which is incredible.

  42. Zephyr (verified owner)

    My skin was peeling like crazy and became really red and sensitive. After I had stopped using it, the skin that grew back was noticeably darker for some reason; I had to stop using it and apply 5% hydroquinone + monobenzone to lighten it, luckily it’s returned to the original color. I strongly discourage this for long-term usage, and combining it with monobenzone would make your skin hurt like crazy so DON’T Do IT.

  43. Sulagna Bal (verified owner)

    I received this item after a long month of wait after placing an order. The packets were sealed well and the products were undamaged and sealed. I am so satisfied by their customer service! THanx but the delivery time is killing.

  44. S. Saeed (verified owner)

    I was a little skeptical because when I placed the order I got a confirmation email that said my order would be shipped within 24hrs and I would receive tracking info…..well that didn’t happen. I sent an email to enquire and was told there was a little delay because of covid. It would be helpful for them to update their confirmation email if that’s the case….

    Anyway, after about 3 weeks ish, I recieved the product. Packaged well, in its original packaging with a seal. Product works well. I recommend this site !

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