What is L-Glutathione Cream Agefine®
Agefine® cream is a skin whitening cream enriched with a key ingredient L-Glutathione, and other potent components for flawless skin, such as Glycolic acid, Shea butter, Vitamin E, Vitamin C, Bearberry Extract, and Licorice Extract coupled with a very powerful body-protecting chemical. Agefine® cream gives you a fair, smooth and perfect skin as one of the best natural skin whitening cream available on the market. Apply cream throughout face and neck regularly in the morning and evening.
L-Glutathione (GSH) is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals. It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side chain and the amine group of cysteine, and the carboxyl group of cysteine is attached by a normal peptide linkage to a glycine.
Details about Glutathione Cream
Glutathione plays an important role in preventing oxidative damage to the skin. In addition to its many recognized biological functions, glutathione has also been associated with skin lightening ability. The role of glutathione as a skin whitener was discovered as a side effect of large doses of glutathione. Glutathione utilizes different mechanisms to exert its action as a skin whitening agent at various levels of melanogenesis. It inhibits melanin synthesis by means of stopping the neurotransmitter precursor L-DOPA’s ability to interact with tyrosinase in the process of melanin production. Glutathione inhibits the actual production as well as agglutination of melanin by interrupting the function of L-DOPA.
Another study found that glutathione inhibits melanin formation by direct inactivation of the enzyme tyrosinase by binding and chelating copper within the enzyme’s active site. Glutathione’s antioxidant property allows it to inhibit melanin synthesis by quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation. Its antioxidant property also protects the skin from UV radiation and other environmental as well as internal stressors that generate free radicals that cause skin damage and hyperpigmentation.
In most mammals, melanin formation consists of eumelanin (brown-black pigment) and pheomelanin ( yellow-red pigment) as either mixtures or copolymers. Increase in glutathione level may induce the pigment cell to produce pheomelanin instead of eumelanin pigments. Research by Te-Sheng Chang found the lowest levels of reduced glutathione to be associated with eumelanin type pigmentation, whereas the highest ones were associated with the pheomelanin. As a result, it is reasonable to assume that the depletion of glutathione would result in eumelanin formation. Prota observed that decreased glutathione concentration led to the conversion of L-Dopaquinone to Dopachrome, increasing the formation of brown-black pigment (eumelanin).