Trunex MS® Micro Gel

Tretinoin 0.04% Micro Aqueous Gel USP

5.00 out of 5

(1 customer review)

USD $28.00 (EUR €23.80)

Brands:KLM Labs

Tretinoin Micro gel Trunex MS is a medicated gel used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Tretinoin belongs to a class of medications called retinoids. It works by affecting the growth of skin cells.

One of the most effective and affordable anti-aging medications available today is tretinoin – a topical retinoid that can reduce the visibility of wrinkles, liver spots, skin discoloration and other signs of aging. Tretinoin works by speeding up your body’s production of new skin cells, letting you replace old skin with new skin faster.

As well as anti-aging, it’s also widely used as a topical acne treatment. Like most medications, tretinoin isn’t instant. Below, we’ve explained how tretinoin works as an anti-aging and wrinkle reduction treatment, as well as how long it normally takes for the effects of tretinoin to become visible.

Size: 15g / 0.53oz
Brand name: Retin-A Micro Gel, Atralin, Renova, Avita
Title Range Discount
Items: 2 - 4 5%
Items: 5 - 8 10%
Items: 9 + 15%


What is Trunex MS® 0.04% Tretinoin Micro Gel

Tretinoin Micro gel Trunex MS is manufactured by reputable KLM Pharma. The tube contains 15g of microsphere aqueous gel which is well suitable for oily to normal skin types. Trunex MS Aqueous Gel is a form of vitamin A. When applied on the scalp, it works by promoting the growth of hair follicles, thereby stimulating hair growth. When used on the skin, it reduces oil production in the skin, treats acne, replenishes acne-prone skin and helps keep your pores open.

This retinoid gel is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Your skin may look worse before it improves: tretinoin, as well as other topical retinoids, are well known for causing a “purge” during the first few weeks of treatment. While your skin adjusts to tretinoin, it’s not uncommon to experience a high level of dryness, as well as issue.

Precautions during use Trunex MS® 0.04% Tretinoin Micro Gel

Trunex MS Aqueous Gel may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Trunex MS Aqueous Gel is unsafe to use during lactation. Data suggests that the drug may cause toxicity to the baby, or the mother is suffering from a condition in which breastfeeding is not advisable.

How to use and expert advice

  • You have been prescribed Trunex MS Aqueous Gel for the treatment of acne
  • Clean the area to be treated with water and a non-medicated soap, and let it dry for 20-30 minutes before applying Trunex MS Aqueous Gel
  • It may increase the severity of the lesions in the first few weeks of use. Continue using it as prescribed by your doctor
  • It may cause a stinging sensation or a feeling of warmth when you first start using it. Inform your doctor if this persists
  • Avoid exposure to sunlight while using Trunex MS Aqueous Gel as it increases the sensitivity of your skin.
  • Use protective measures such as sun-cream or protective clothing
  • Do not use Trunex MS Aqueous Gel if you are pregnant or breastfeeding

How Does Tretinoin Work?

Tretinoin works by dramatically increasing your body’s rate of skin cell turnover – the process through which new skin cells are produced. As we get older, our bodies begin to produce new skin cells at a slower speed (slower metabolism). For example, an individual in their 20s might complete a new skin cell cycle every month, while someone in their 30s or 50s could take around two months to complete a full skin cell turnover.

Skin cell turnover is the biological process through which your body replaces old skin cells with new ones. New skin cells are formed in the bottom layer of the epidermis (the outer layer of your skin that’s closest to the surface). After the cell is created, it gradually travels up towards the surface layer of your skin, where it’s exposed to sunlight and air.

The longer your upper skin cells are exposed to sunlight and air, the greater the effects of photoaging – the process through which your skin starts to develop wrinkles, spots, smile lines and other signs of aging. By stimulating skin cell turnover and exfoliating the layers of your skin that are exposed to direct sunlight, tretinoin plays a powerful role in slowing down and reversing the development of lines, wrinkles, and discoloration.

How Long Does Tretinoin Take to Reduce Wrinkles?

Tretinoin starts working immediately – you’ll start to get the benefits from this retinoid as soon as you apply it to your skin. However, it usually takes several months before you’ll see a noticeable improvement in your skin’s clarity and quality after using tretinoin, generally, it is taking from 3 to 8 months to see dramatical results with tretinoin.

In one study, researchers observed a clear improvement in skin quality after participants applied topical tretinoin for 84 days. After 84 days, the participants showed a significant improvement in supralabial wrinkles (facial wrinkles near the lips), the nasolabial fold area (“smile lines” or “laugh lines”) and pigmentation (dark or discolored patches of skin, melasma).

Another study from 1990, which lasted for 12 weeks, showed “significant improvements in fine wrinkling around the eyes, crease lines around the mouth and cheeks, wrinkling on the dorsum of the hands and yellow discoloration” after treatment with tretinoin cream.

Additionally, a 1988 study of topical tretinoin as an anti-aging treatment found that 14 out of 15 people given tretinoin cream “had an improvement in photoaging,” compared to none of the people given a non-therapeutic vehicle cream. In general, studies of topical tretinoin for anti-aging usually show results after two to four months of daily use.

Tretinoin Works Best as a Long-Term Treatment

While tretinoin produces anti-aging results in as little as 84 days, it’s even more effective as a long-term wrinkle and aging prevention treatment.

Long-term studies of tretinoin tend to show the most dramatic results, with people experiencing significant reductions in the appearance of fine wrinkling, coarse wrinkling, skin laxity and other signs of photoaging.

In a 1989 study of people with photodamaged facial skin, half of the participants were given a cream containing tretinoin for daily use, while the other half of the study participants were given a non-therapeutic vehicle.

After six months, participants given tretinoin showed significant improvements in fine wrinkling, coarse wrinkling, sallowness, looseness, and hyperpigmentation. These patients also reported a self-perceived improvement in an appraisal questionnaire.

A 1991 study of long-term tretinoin treatment showed similar results. Participants given tretinoin .04% gel for 24 weeks showed an “overall improvement in photodamaged skin,” including a reduction in fine wrinkling, mottled hyperpigmentation, roughness and laxity.

Interestingly, study participants given a cream with a lower amount of tretinoin (.01% tretinoin, as opposed to .05% in the other group) didn’t experience the same anti-aging benefits as the participants were given tretinoin .05% cream.

Another study from 1991 produced similar findings. Participants given a 0.05% tretinoin cream saw an increase in epidermal thickness (skin thickness), as well as a reduction in skin melanin content and compaction of the outer layer of the skin after 24 weeks of tretinoin cream use.

The study concluded that the changes in tretinoin-treated skin “establish the biologic activity of the new emollient cream formulation” (tretinoin cream) and “may partially account for the clinical improvements in photodamage observed in the same group of subjects.”

In simple terms, tretinoin not only produces an improvement in skin quality and a reduction in wrinkles in short-term studies – it’s also highly effective at reducing wrinkles, discoloration and other signs of aging when used over the long term.


Tretinoin USP equivalent to Ahydrous Tretinoin as microsphere 0.04%

Aqueous gel baase q.s.