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Melospot® Depigmentor Cream

Hydroquinone 4% + Octinoxate + Oxybenzone + Titanium Dioxide

(5 customer reviews)

USD $30.00


Melospot® is a strong skin bleaching agent hydroquinone 4 percent mixed with potent sun protectors like Oxtinoxate, Oxybenzone and Titanium Dioxide.

Prescribed in the most stubborn hyperpigmentation cases.

Size: 20g / 0.7oz
Title Range Discount
Items: 2 - 4 5%
Items: 5 - 8 10%
Items: 9 + 15%


What is Melospot® Cream

Melospot skin lightener is a strong chemical depigmenting agent manufactured by reputable E-Derma. Melospot contains skin bleacher Hydroquinone 4% and several skin sun protectors Octinoxate + Oxybenzone + Titanium Dioxide. Topical application of hydroquinone 4 produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3, 4-dihydroxyphenylalanine and suppression of other melanocyte metabolic processes. Exposure to sunlight or ultraviolet light will cause repigmentation of bleached areas. Hydroquinone USP, 4% Skin Bleaching Cream is indicated for the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines, and other unwanted areas of melanin hyperpigmentation.

Test for skin sensitivity before using by applying a small amount to an unbroken patch of skin; check within 24 hours. Minor redness is not a contraindication, but where there is itching or vesicle formation or excessive inflammatory response further treatment is not advised. Close patient supervision is recommended. Do not use if you are pregnant, planning to become pregnant or breastfeeding.

Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight sustains melanocytic activity. To prevent repigmentation, during treatment and maintenance therapy, sun exposure on treated skin should be avoided by application of a broad-spectrum sunscreen (SPF 15 or greater) or by use of protective clothing. Avoid contact with eyes and mucous membranes.

Main ingredients of Melospot® Cream

Hydroquinone 4 – Hydroquinone is a melanin synthesis inhibitor. It is prepared from the reduction of p-benzoquinone with sodium bisulfite. It occurs as fine white needles that darken on exposure to air. The chemical name for hydroquinone is 1,4-benzenediol. Melospot skin lightening cream is a skin bleaching and lightening agent used in treating freckles, age spots, melasma and other skin pigmentations that may occur due to pregnancy, skin trauma, the use of birth control pills, or hormone replacement therapies. The cream may also be used to treat acne scars and other forms of skin disorders and discoloration. The way Melospot Skin Lightening Cream works is by polishing and purifying the deeper layers of the skin thus erasing spotted areas and blemishes along the way.

Octinoxate – Octinoxate filters UV‐B rays from the sun. It does not protect against UV-A rays. Octinoxate dissolves in oil, which makes it a fat-seeking substance in the body. It is formed by combining methoxy cinnamic acid and 2-ethyl hexanol- compounds that are not harmful on their own. When mixed together, they form a clear liquid that does not dissolve in water. In products other than sunscreens, it is used as a UV filter to protect the products from degrading when exposed to the sun.

Oxybenzone – Oxybenzone is an organic compound that is a benzophenone derivative. Oxybenzone works as a sunscreen by absorbing UV radiation. During this process, a chemical reaction occurs and the sun’s UV rays are converted into heat and released from the skin.

Titanium Dioxide – Titanium dioxide is derived from titanium. It’s a natural mineral that is used in sunscreen and cosmetics to whiten, thicken, and lubricate, all while offering protection against the sun. Invisible to the naked eye: It’s typically scaled-down much smaller, between 10 and 100 nanometers, making it less noticeable on the skin. This makes it a good choice for those with darker skin, as it doesn’t leave an opaque layer. Non-comedogenic and gentle on skin: Just like zinc oxide, titanium dioxide is also noncomedogenic. It’s extremely gentle, making it a great choice for those with sensitive skin. While it doesn’t provide as much protection from long-wave UVA rays, titanium dioxide is extremely effective at blocking short-wave UVA and UVB, making it a great choice for casual daily sun exposure.


  • Hydroquinone 4%
  • Octinoxate
  • Oxybenzone
  • Titanium Dioxide
  • Cream base q.s

5 reviews for Melospot® Depigmentor Cream

  1. Emelie Abaton

    Value for money! Very good product. I have been using it every night and really I can see the has become softer. The brown spots now have a very light pink look. Almost gone!!! I will apply again once more. Self-confidence up again!!!! Do not need to cover up with makeup anymore. I am really really happy about this and highly recommend it. Have patience.

  2. Fern

    Giving 5 stars as This product is working. It has been a month now and I use the product only once at night versus the recommended twice daily. It seems to pull off layers at a time, reviving the old dark areas to new ones. The small tube lasts only about a month w daily applications and I bought the next 2 tubes more!

  3. Carolin

    This is the first product I have tried, that actually does fade brown spots on the face!! Have noticed a real improvement on some spots and a degree of improvement on most of them. I am a fan of 4% with caveats. I have older spots from the dermatological laser (I am NC 30-35, Asian, combination skin, tending towards dry, and relatively accustomed to BHA, AHA, and both prescription and nonprescription retinoids). I use it, and I would repurchase it if I lost the tube, but I often don’t have the patience to dab for three months straight. My spots are lighter, but that may be a combination of time, retinoids, BHA, AHA, Vitamin C, and niacinamide (I rotate products and generally do not use them daily).

  4. Sue Bargan

    I had dark melasma on my face, which I could no longer cover with makeup, and decided to give this a try. It worked amazingly. I was nervous at first as my skin started breaking out in whiteheads but I am guessing that was from the cream purging my skin. I then began peeling and my forehead was very red and dry. I was worried that it had not worked because after several days of not using it my skin was still very red in the area that I used the serum. However, after moisturizing heavily for several days (again not using the cream) my skin continuously peeled and my melasma was gone. I am forever in the debt of this company, only 4 weeks required to remove my spots!! By the way, this cream contains SPF so it is not necessary to apply extra on top.

  5. shainy

    Amazing results, love this cream. Mine is oily skin, my face was very pigmented.
    This cream does what it says, and sometimes there is a tingly sensation, not pleasant but tolerable, the week after I used it, my dark facial spots are fading away, the skin is peeling off, gently, and new skin showing in. I spent thousands of dollars in laser treatments and cosmeticians, good dermatologists, and expensive Obagi creams and nothing. You will follow their instructions and rest the skin after a month of use, it’s important to read the instructions. It works!

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