Description
What is Rejusure® Elbow & Knee Whitening Cream?
This cream exfoliates to remove dead skin cells which brighten, soften, and smoothens skin. It is best for eliminating dark spots & blemishes, dryness, and dullness & uneven skin tone lightening. Add this cream to your daily skincare regime, and never compromise on these forgotten areas of care again. Rejusure® Products are paraben-free, sulfate-free, gluten-free, cruelty-free, and environmentally friendly.
Glycerin treats dull and dry skin by hydrating the skin and retaining moisture. Skullcap gently restores natural radiance while Saxifraga lightens the skin. It helps in reducing discoloration on the knees and elbows. Glutathione with Vitamin C, Grape Seed, Alpha-Lipoic Acid, and Vitamin E is a great ingredient full of antioxidants and powerful extracts to whiten and lighten your skin.
Main active ingredients of Rejusure® Elbow & Knee Whitening Cream
Kojic Acid – melanin is a naturally occurring pigment in the body that gives the eyes, hair, and skin their color. An amino acid called tyrosine is needed to support the production of melanin. Kojic acid works by blocking tyrosine from forming, which then prevents melanin production. Decreased melanin production may have a lightning effect on the skin.
Peony – Known in Traditional Chinese medicine as the “king of flowers”, Peony Root Extract is a natural antioxidant often found within skincare formulas, known to help brighten the complexion.
Scutellaria – The growing interest in skin lightening has recently renewed attention to the esthetic applications of Chinese herbal medicine. Although Scutellaria Baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. This study reports three major findings: Scutellaria has a potent inhibitory effect on melanogenesis; wogonin and its glycoside are the active components of Scutellaria baicalensis; and (3) O-methylated flavones from Scutellaria baicalensis, such as wogonin, inhibit intracellular melanosome transport.
Using a melanin quantification assay, we showed that Scutellaria baicalensis potently inhibits melanogenesis in B16F10 cells. Componential analyses revealed that the main components of S. baicalensis are baicalin, wogonoside, baicalein, wogonin, and oroxylin A. Among these five flavones, wogonin and wogonoside consistently inhibited melanogenesis in both B16F10 melanoma cells and primary melanocytes. Wogonin exhibited the strongest inhibition of melanin production and markedly lightened the color of skin equivalents. We identified microphthalmia-associated transcription factors and tyrosinase-related proteins as potential targets of wogonin- and wogonoside-induced melanogenesis suppression. In culture, we found that the melanosomes in wogonin-treated B16F10 cells were localized to the perinuclear region. Immunoblotting analyses revealed that wogonin significantly reduced melanophilin protein, which is required for actin-based melanosome transport. Other actin-based melanosome transport-related molecules, i.e., Rab27A and myosin Va, were not affected by wogonin.
Cotreatment with MG132 blocked the wogonin-induced decrease in melanophilin, suggesting that wogonin promotes the proteolytic degradation of melanophilin via the calpain/proteasomal pathway. We determined that the structural specificities of the mono-O-methyl group in the flavone A-ring and the aglycone form were responsible for reducing melanosome transport. Furthermore, wogonin and two wogonin analogs, mono-O-methyl flavones, strongly suppressed melanosome transport. Our findings suggest the applicability of S. baicalensis in the esthetic field. Thus, we propose a novel pharmacologic approach for the treatment of hyperpigmentation.
Glutathione – is one of the most powerful antioxidants in our body. This is gaining traction in terms of skin whitening treatment and achieving the desired pigmentation. With very less to no side-effect, Glutathione skin whitening is by far the most chosen whitening treatment. It is tropically administered through a whitening pill or glutathione cream.
Arbutin- a brown spot that comes from pigments that are produced in cells called melanocytes, which contain enzymes called tyrosinase. They can activate anytime they come in contact with UV light, which is why you’ll notice freckles and sun spots starting to develop if you spend too much time in the sun. That’s when arbutin comes in – it blocks tyrosinase and keeps dark spots at bay.
Saxifraga Flowers – Brighten skin and help fade dark spots and discolorations. They have remarkable lightening effects as the plants work in synergy to inhibit the activity of tyrosinase. This active ingredient is exceptionally intense in its ability to fight against skin aging.
