What is Daruvir R® Darunavir Tablet?
Darunavir, co-administered with ritonavir, is indicated in combination with other antiretrovirals for the treatment of HIV infection. In an open-label, randomized trial in treatment-naïve patients, a darunavir/ritonavir regimen was non-inferior virologically to lopinavir/ritonavir and better tolerated.
Darunavir: This is a protease inhibitor (PI) that inhibits the replication of the HIV virus in combination with other antiretroviral agents (ARV). Initial studies indicate that darunavir may be active against strains of HIV that are already resistant to some other currently available protease inhibitors.
Ritonavir: This is also a protease inhibitor used to inhibit the replication of the HIV virus in combination with other antiretroviral agents or to increase blood levels of other protease inhibitors. The combination of darunavir and ritonavir is taken together because ritonavir will “boost” the level of darunavir and increase its effect.
HIV (human immunodeficiency viruses) over time causes acquired immunodeficiency syndrome (AIDS). It is a condition in which the immune system weakens, leading the body to become prone to infections and cancers. Darunavir and Ritonavir are used in combination for treating patients suffering from HIV infection. It inhibits the replication of HIV. The fixed-dose combination therapy may improve the overall patient treatment outcome.
Darunavir + Ritonavir price is low if you purchase its generic brand, you can buy it from any authorized seller like the OKDERMO Skin Store. The buyer should check the existing law in their home country before importing the product.
Daruvir R® Darunavir Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome).
Daruvir R® Darunavir Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine.
The most common side effects of this medicine are headaches, nasal congestion, diarrhea, nausea, weakness and tiredness, cough, and rash. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel lazy or weak, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with the side effects, so stay hydrated.
Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular blood tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse.
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Darunavir + Ritonavir tablets, commonly referred to as the Prezista combo, offer a powerful approach to HIV treatment. By inhibiting the replication of the HIV virus in the body, this combination medications helps suppress the virus and maintain a healthier immune system. Experience the potential of Darunavir + Ritonavir in effectively managing your HIV condition.
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Opting for Darunavir + Ritonavir tablets, or Prezista combo, demonstrates your commitment to comprehensive HIV care. With its proven efficacy and endorsement as a potent HIV treatment, Darunavir + Ritonavir stands as a symbol of modern healthcare. By incorporating this combo into your treatment plan, you’re taking a proactive step toward managing your HIV condition effectively.
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Dosage of Daruvir R® Darunavir Tablets
Darunavir and ritonavir should be taken orally at about the same time each day, Daruvir R® tablets should be taken with food to increase absorption and decrease side effects. Darunavir and ritonavir tablets should be swallowed whole with water. The tablets should not be opened, broken, or chewed.
Daruvir R® Side Effects
Darunavir: The most common side effects of darunavir include nausea, vomiting, diarrhea, stomach pain or gas, tiredness, allergic skin rash, headache, yellowing of the skin or eyes, and pale stool.
Ritonavir: The most common side effects of ritonavir include nausea, diarrhea, vomiting, stomach pain, taste changes, and abnormal feelings in the hands, feet, or in and around the mouth.
Warnings and Precautions
Some medications can interact with darunavir and/or ritonavir requiring a dosage adjustment or an alternate medication: e.g.. Some antihistamines, sedatives, anti-tuberculosis medications, some antifungal medications, narcotic analgesics, methadone, heart/blood-pressure medications, psychiatric medications, anticonvulsants, transplant/immunosuppressant medications, warfarin, cholesterol-lowering agents, sildenafil (Viagra), oral contraceptives (birth control pill), ergot containing migraine medications.
- Avoid the following Herbal/Natural remedies: St. John’s Wort, Milk Thistle, raw Garlic, or Garlic capsules which may decrease levels of darunavir.
- Protease inhibitors not only interact with each other but may change the level of other medications (by changing the processing of drugs in your liver).
- Always check with the pharmacist or your doctor before starting any new medications (prescription, non-prescription, and herbal) to ensure the safety of the combination.
- The consumption of alcohol is not recommended while on the initial 4 weeks of the therapy and alcohol should be used with caution thereafter.
- In order to increase absorption and decrease in the side effects, Darunavir and ritonavir should be taken with food.
- The combined darunavir and ritonavir should be consumed at the same time every day because missing doses or taking doses late can lead to the development of drug resistance.
- Darunavir has been shown to increase total cholesterol and/or triglyceride levels. Redistribution or accumulation/loss of body fat (lipodystrophy) and increases in blood sugars can occur.
- Sometimes Darunavir may affect your liver and cause a change in liver function tests. Contact your healthcare provider if you have stomach pain that doesn’t go away and/or have signs of jaundice (e.g. yellowing of the skin or eyes, pale stool, etc.).
Some medications can interact with darunavir and/or ritonavir requiring a dosage adjustment or an alternate medication: e.g. Some antihistamines, sedatives, anti-tuberculosis medications, some antifungal medications, narcotic analgesics, methadone, heart/blood-pressure medications, psychiatric medications, anticonvulsants, transplant/immunosuppressant medications, warfarin, cholesterol-lowering agents, sildenafil (Viagra), oral contraceptives (birth control pill), ergot containing migraine medications.