What is Oxytan® Anti Ageing Cream?
- Unique skin whitening formula that evens out skin tone and flights with signs of skin aging
- Lightens the skin and fades dark spots
- Inhibits the formation of melanin that leads to pigmentation
- Improves skin elasticity and delivers anti-aging benefit
- Suitable for all skin types
Oxytan® Anti-aging Cream is a skin-lightening cream with a lightening agent that inhibits the tyrosinase enzyme responsible for melanin formation and lightens pigmentation, freckles, and age spots, and also improves skin firmness with its antiaging benefit.
- Oxyresveratrol acts as a skin-lightening and anti-aging ingredient and lightens pigmentation
- Licorice extract acts as a melanin inhibitor and improves dark spots and prevents future hyperpigmentation
- Vitamin E improves skin elasticity. Lightens the skin and reduces fine lines and wrinkles
- Niacinamide lightens dark spots and decreases hyperpigmentation
A bright complexion is the ultimate marker of a healthy complexion, but we know all too well how difficult it can be to achieve a radiant glow if you have problems with hyperpigmentation (dark spots, melasma, sun damage, and alike). That’s why we devoted ourselves to finding a brand-new skin-brightening ingredient that could deliver unparalleled results while nourishing and caring for the skin. The results of our research uncovered oxyresveratrol (Oxy-R), a high-performance molecule that rapidly restores radiance without damaging or bleaching the skin.
In the past, hydroquinone was widely used to treat hyperpigmentation. But recently there has been some controversy surrounding its safety. Always ready to innovate with newer, safer ingredients, Linux Labs developed the revolutionary Oxytan® Anti Ageing Cream featuring the star of our pigmentation solution Oxyresveratrol.
Naturally occurring in white mulberries native to northern China, oxyresveratrol is exceptionally good at blocking tyrosinase, the enzyme that controls the production of melanin. Less pigment means that hyperpigmentation is much less likely to occur. In fact, oxyresveratrol was found to be 32 times better at inhibiting tyrosinase than kojic acid. Oxy-R is also an antioxidant, which means it provides superior skin protection against the aging effects of free radicals while reducing inflammation throughout the skin.
Whitening and skin care effects of Oxyresveratrol: In early, Mongolsuk et al. (1957) found oxyresveratrol in Artocarpus lakoocha (Moraceae) (Charoenlarp et al., 1981) and proved that it has an obvious whitening effect. Later, the whitening effect of oxyresveratrol had been verified by some related experiments in guinea pigs (Tengamnuay et al., 2003) and humans (Tengamnuay et al., 2006). With in-depth research, more and more studies showed that an excessive amount of melanin would cause pigmentation disorders which had great harm to human health, and tyrosinase was the key enzyme in the production of melanin.
The addition of inhibitors that inhibit tyrosinase activity in whitening cosmetics, achieved skin whitening through the restraint of melanin formation (Lu et al., 2001). Moreover, Shin et al. (1998a) concluded the mechanism of the whitening effect of oxyresveratrol: in vivo tyrosinase could convert tyrosine into dopa quinine and then formed melanin with a series of chemical reactions. When L-dopa was used as a substrate, oxyresveratrol inhibited the dopa oxidase activity of tyrosinase in a non-competitive manner.
Additionally, Ki values suggested that oxyresveratrol exhibited about a 150-fold more potent inhibitory effect than resveratrol and exerted more effective inhibition on the enzyme than the well-known inhibitors of azelaic acid, curcumin, kojic acid (Zheng et al., 2011) and mimosine. The effect was clear even though they were determined by similar assay systems in different laboratories (Lu et al., 2001).
On the other hand, some similar studies found that compared with mulberroside A, oxyresveratrol had better performance in inhibiting ultraviolet B (UVB) irradiation-induced melanogenesis in brown guinea pig skin (Park et al., 2011); compared with dioscin and Mulberroside A, oxyresveratrol showed stronger tyrosinase inhibitory activity (Liang et al., 2012; Kim et al., 2012). Oxyresveratrol also demonstrated a potent inhibitory effect on mushroom tyrosinase activity, which was 32-fold stronger than kojic acid (Kim et al., 2002). Recently, through scientific studies and investigations, Zheng et al. (2012) suggested oxyresveratrol as a good source of natural tyrosinase inhibitor with great potential and it can be used in foods as an anti-browning agent and in cosmetics as a skin-whitening agent.
Resveratrol and oxyresveratrol are naturally occurring phenolic compounds with various bioactivities, but their uses in cosmetics have been partly limited by their chemical instabilities. This study was performed to examine the anti-melanogenic effects of the acetylated derivatives from resveratrol and oxyresveratrol. Resveratrol and oxyresveratrol were chemically modified to triacetyl resveratrol and tetraacetyl oxyresveratrol, respectively. The acetylated compounds were less susceptible than the parent compounds to oxidative discoloration. The acetylated compounds inhibited the activities of tyrosinases less than parent compounds in vitro, but they were as effective at cellular melanogenesis inhibition, indicating bioconversion to parent compounds inside cells. Supporting this notion, the parent compounds were regenerated when the acetylated compounds were digested with cell lysates.
Although resveratrol and triacetyl resveratrol inhibited tyrosinase activity less effectively than oxyresveratrol and tetraacetyl oxyresveratrol in vitro, they inhibited cellular melanogenesis more effectively. This discrepancy was explained by strong inhibition of tyrosinase expression by resveratrol and triacetyl resveratrol. Experiments using a reconstituted skin model indicated that resveratrol derivatives can affect melanin synthesis and cell viability to different extents. Collectively, this study suggests that acetylated derivatives of resveratrol have great potential as anti-melanogenic agents for cosmetic use in terms of efficacy, safety, and stability.
How to use Oxytan® Anti Ageing Whitening Cream
The unique skin whitening formula facilitates those with hyperpigmentation and uneven skin tone. Regular application improves skin tone, and radiance and improves skin fairness. Shall be applied in the required quantity in a circular motion over the facial area, neck, and body, under the arm, etc, both day and night or as suggested by the dermatologist.