Fitaro® Semaglutide Subcutaneous Injection

Description

What is Fitaro® Semaglutide Injection For Weight Loss?

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Semaglutide Subcutaneous Injection

Semaglutide, sold under the brand names Ozempic, Wegovy, and Rybelsus, is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management, developed by Novo Nordisk in 2012. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. It can be administered by subcutaneous injection or taken orally.

Semaglutide is a glucagon-like peptide-1 receptor agonist. The most common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation. In 2020, semaglutide was the 129th most commonly prescribed medication in the United States.

Semaglutide is a GLP-1 analogue with 94% sequence as same as human GLP-1. Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP- receptor. GLP-1 is a physiological regulator of appetite and caloric intake. It is also present in several areas of the brain that are involved in appetite regulation. Semaglutide lowers body weight through decreased calorie intake and an overall reduced appetite. It also stimulates insulin secretion and reduces glucagon secretion in a glucose-dependent manner.

Indications for Fitaro® Semaglutide Injection

An adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of :

• 30 kg/m2 or greater (Obesity) or
• 27 kg/m2 or greater (Overweight) in the presence of at least one weight-related comorbid condition (e.g. hypertension, type 2 diabetes mellitus, or dyslipidemia).

Dosage & Administration of Ozempic Generic

The starting dose is 0.25 mg Semaglutide once weekly for 4 weeks subcutaneously. Then in 4-week intervals, the dose should be increased until a dose of 2.4 mg is reached. Patients should follow the dose escalation schedule given below.

Side Effects of Wegovy Generic

The most common adverse reactions are nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, eructation, hypoglycemia in patients with type 2 diabetes, flatulence, gastroenteritis, and gastroesophageal reflux disease.

Precautions for Semaglutide

Pancreatitis: Semaglutide should be discontinued promptly if pancreatitis is suspected and it should not be restarted if pancreatitis is confirmed.

Acute Gallbladder Disease: If cholelithiasis is suspected, gallbladder studies and clinical follow-up are indicated.

Hypoglycemia: Concomitant use with an insulin secretagogue or insulin may increase the risk of hypoglycemia. Reducing the dose of insulin secretagogue or insulin may be necessary.

Diabetic Retinopathy: Patients with diabetic retinopathy should be monitored.

Heart Rate: Heart rate should be monitored at regular intervals.

Suicidal behavior and Ideation: Monitoring should be done for depression or suicidal thoughts. If symptoms develop, semaglutide should be discontinued.

Use in Pregnancy & Lactation

Semaglutide should not be used during pregnancy. If a patient wishes to become pregnant Semaglutide should be discontinued at least 2 months before a planned pregnancy. As a risk to a breastfed child cannot be excluded, Semaglutide should not be used during breast-feeding.

Pediatric population: The safety and efficacy of semaglutide in children and adolescents below 18 years have not yet been established. No data are available.

Drug Interaction

Semaglutide lowers blood glucose and can cause hypoglycemia. The risk of hypoglycemia is increased when it is used in combination with insulin secretagogues (sulfonylureas) or insulin. So when initiating Semaglutide, the dose of concomitantly administered insulin secretagogue (sulfonylureas) or insulin should be reduced.

Overdose: The most commonly reported adverse reaction was nausea, vomiting, and hypoglycemia. All patients recovered without complications. In the event of overdose appropriate supportive treatment should be initiated according to the patient’s clinical signs and symptoms.

Storage: Store at 2 0C to 8 0C (in a refrigerator). Do not freeze. Keep out of reach of children.

Commercial Pack:

• Fitaro 0.25 mg injection: Each box contains 1 pre-filled syringe of Semaglutide 0.25 mg Injection.
• Fitaro 0.50 mg injection: Each box contains 1 pre-filled syringe of Semaglutide 0.50 mg Injection.
• Fitaro 1 mg injection: Each box contains 1 pre-filled syringe of Semaglutide 1 mg Injection.
• Fitaro 1.7 mg injection: Each box contains 1 pre-filled syringe of Semaglutide 1.7 mg Injection.
• Fitaro 2.4 mg injection: Each box contains 1 pre-filled syringe of Semaglutide 2.4 mg Injection.