Description
What is Saxenda® Liraglutide injection?
Saxenda® (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with excess weight who also have weight-related medical problems or obesity and children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity to help them lose weight and keep the weight off. Saxenda® should be used with a reduced-calorie diet and increased physical activity.
Saxenda® addresses one of your body’s natural responses to weight loss. Saxenda® works like GLP-1 to regulate your appetite, which can lead to eating fewer calories and losing weight. Your body naturally produces an appetite hormone known as glucagon-like peptide-1 (GLP-1) that helps to regulate your hunger. Saxenda® works like GLP-1 by regulating your appetite, which can lead to eating fewer calories and losing weight.
Saxenda (liraglutide) is used for weight loss and to help keep weight off once weight has been lost, it is used for obese adults or overweight adults who also have weight-related medical problems. Saxenda can be used in children aged 12 to 17 years who with obese and who have a body weight above 132 pounds (60 kg). Saxenda is used together with a healthy diet and exercise.
Saxenda is an injection given once a day under the skin (subcutaneous) from a multi-dose injection pen. Saxenda contains the same active ingredient (liraglutide) as Victoza. The difference between Saxenda and Victoza is they are different strengths and they are FDA approved for different conditions. Saxenda® (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with excess weight, (needles should be purchased separately).
Saxenda is not for treating type 1 or type 2 diabetes. It is not known if Saxenda is safe and effective in children under 12 years of age. It is not known if Saxenda is safe and effective in children aged 12 to 17 years with type 2 diabetes.
Saxenda® (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with excess weight who also have weight-related medical problems or obesity, and children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity to help them lose weight and keep the weight off. Saxenda® should be used with a reduced-calorie diet and increased physical activity.
Saxenda® and Victoza® have the same active ingredient, liraglutide, and should not be used together or with other GLP-1 receptor agonist medicines.
- It is not known if Saxenda® is safe and effective when taken with other prescription, over-the-counter medicines, or herbal weight-loss products.
- It is not known if Saxenda® is safe and effective in children under 12 years of age.
- It is not known if Saxenda® is safe and effective in children aged 12 to 17 years with type 2 diabetes.
Saxenda® Liraglutide injection indications
Saxenda® (liraglutide) injection 3 mg is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in:
- Adult patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (eg, hypertension, type 2 diabetes mellitus, or dyslipidemia)
- Pediatric patients aged 12 years and older with body weight above 60 kg (132 lbs) and initial BMI corresponding to 30 kg/m2 or greater for adults (obese) by international cut-offs
How does Saxenda work?
Saxenda works to help weight loss by lowering appetite, and slowing gastric emptying which makes you feel full for longer and therefore you decrease your calorie intake. Saxenda is similar to a hormone that occurs naturally in the body and helps control blood sugar, insulin levels, and digestion. Saxenda belongs to a class of medicines called glucagon-like peptide-1 (GLP-1) agonists.
Before using Saxenda
You should not use Saxenda if you are allergic to liraglutide, or if you have:
- multiple endocrine neoplasia type 2 (tumors in your glands);
- a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer); or
- diabetic ketoacidosis (call your doctor for treatment).
You should not use Saxenda if you also use insulin or other medicines like liraglutide (albiglutide, dulaglutide, exenatide, Byetta, Bydureon, Tanzeum, Trulicity).
To make sure Saxenda is safe for you, tell your doctor if you have:
- stomach problems causing slow digestion;
- kidney or liver disease;
- high triglycerides (a type of fat in the blood);
- heart problems;
- a history of problems with your pancreas or gallbladder; or
- a history of depression or suicidal thoughts.
In animal studies, liraglutide caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people using regular doses. Ask your doctor about your risk.
It is not known whether Saxenda will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether liraglutide passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breastfeeding.
Saxenda is not FDA-approved for use by anyone younger than 18 years old.
Is Saxenda a good weight loss drug?
In a clinical study of people taking Saxenda® for 3 years: 56% achieved significant weight loss at year 1, and approximately half of these patients maintained weight loss at 3 years when taking Saxenda® added to a reduced-calorie meal plan and increased physical activity, compared with people not on the drug.
How much weight can you lose in a month with Saxenda?
Some people start seeing results from Saxenda in the first two to four weeks. You may lose about 2% – 4% of your body weight. However, during clinical trials, people taking Saxenda saw a significant weight loss of at least 5% after eight weeks of treatment.
What is the most important information I should know about Saxenda®?
Serious side effects may happen in people who take Saxenda®, including: Possible thyroid tumors, including cancer. Tell your healthcare professional if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats and mice, Saxenda® and medicines that work like Saxenda® caused thyroid tumors, including thyroid cancer. It is not known if Saxenda® will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.
Do not use Saxenda® if you or any of your family have ever had MTC, or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
How should I use Saxenda®?
Inject your dose of Saxenda® under the skin (subcutaneously) in your stomach area (abdomen), upper leg (thigh), or upper arm, as instructed by your health care provider. Do not inject into a vein or muscle.
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