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What Is Tri-luma Cream? Topical Therapy for Melasma

Melasma is a skin disorder that results in dark areas on the face. Tri-luma cream is a topical treatment for melasma. The three active components in this cream are hydroquinone, tretinoin, and fluocinolone acetonide. Melanin gives skin its color. The body produces melanin. Hydroquinone lowers its synthesis. Vitamin A, in the form of retinol, is used to treat wrinkles and fine lines. It helps to enhance skin texture. Fluocinolone is a corticosteroid. It aids in reducing skin irritation. Tri-luma cream must be used under a doctor’s supervision. We will discuss its applications and advantages.

Benefits Of Tri-luma Cream:

Tri-luma Cream is used as a topical treatment for melasma. It offers unique advantages, including:

1. Reduction of skin discoloration:

The decrease in skin discoloration is the main advantage of Tri-luma cream. One of the depigmenting agents included in Tri-luma cream is hydroquinone. Hydroquinone inhibits the action of tyrosinase. It is an enzyme required to synthesize melanin. Melanin pigment is responsible for the skin’s color. Hydroquinone may aid in fading dark facial areas. It also creates an equal skin tone. It lowers melanin synthesis. Studies have shown that combining fluocinolone acetonide, tretinoin, and hydroquinone may successfully treat melasma.

2. Enhancement of skin texture:

The enhancement of skin texture is another advantage of Tri-luma cream. Another active component of Tri-luma cream is retinol. It is a vitamin A well-known for its ability to smooth out wrinkles and fine lines. Tretinoin functions by promoting the synthesis of collagen. It is a protein necessary for preserving the structure of skin. It improves the flexibility of the skin. Additionally, tretinoin can aid in pore size and appearance reduction. It gives skin a smoother and more youthful appearance.

3. Reduction of skin inflammation:

Fluocinolone acetonide is a corticosteroid. It aids in reducing skin irritation. It is an ingredient in Tri-luma cream. Corticosteroids like fluocinolone acetonide may help reduce symptoms like redness, swelling, and itching. Melasma is often linked to skin inflammation. A doctor should supervise the usage of Tri-luma cream. The prolonged use of corticosteroids may have undesirable side effects.

4. Improvement in the melasma:

When used as recommended, tri-luma cream is both safe and efficient. 75% of patients who used Tri-luma cream for eight weeks exhibited substantial improvement in their melasma as compared to 29% of patients who used a placebo cream in a clinical research comprising 1,070 individuals with moderate to severe melasma. Tri-luma cream is a successful topical medication for melasma.

Dosing Of Tri-luma Cream:

Tri-luma Cream dosage will vary depending on several factors. It includes the severity of the skin issue, the patient’s age, medical history, and other drugs they may be taking. Typically, a thin coating of Tri-luma Cream is applied once daily in the evening. It is applied to the skin’s affected areas in the advised dosage.

Apply this cream to dry and clean skin. Gently massage it until absorbed. Follow the doctor’s instructions carefully. Tri-luma Cream should only be used for short time. It is often used at most 8 to 12 weeks at a time. Tri-luma Cream should only be used as directed by a doctor. Its prolonged usage might raise the risk of adverse effects.

How To Use Tri-luma Cream:

Follow the instructions provided by your doctor carefully. Below are some general guidelines for using Tri-luma Cream:

  • Cleanse your skin. Use a gentle, non-medicated cleanser before using Tri-luma Cream. Pat it dry.
  • Apply a thin coating of Tri-luma Cream with your fingers. Keep the cream out of your lips, nose, and eyes.
  • Gently massage the cream into your skin. Do not wash it off.
  • Apply Tri-luma Cream once daily. It is preferred to use at night. Do not apply the cream more frequently.
  • It is critical to protect the skin from UV rays. Use an SPF 30 or higher wide-spectrum sunscreen.
  • Avoid using additional drugs on the same parts of your face where you put Tri-luma Cream.


Several precautionary measures should be taken. They ensure the safe and effective use of this medication. Some of these include:

  • Avoid sun exposure: While using Tri-luma Cream, protecting your skin from the sun rays is essential. Wear protective clothing.  Use a sunscreen with an SPF of 30 or higher.
  • Avoid using on broken or irritated skin: Do not apply Tri-luma Cream to broken or sunburned skin.
  • Do not use other medications: Avoid other topical creams or lotions on the same areas of your face. Consult your healthcare professional.
  • Do not use during pregnancy or breastfeeding: Tri-luma Cream should not be used during pregnancy or while breastfeeding.
  • Inform your healthcare professional: Inform your healthcare professional if you are taking any other medicines. It includes prescription and over-the-counter medications. These may interact with Tri-luma Cream.
  • Do not use on children: Tri-luma Cream has not been studied in children under 18. Its safety and efficacy have not been established in this population.


  1. Helen M. “A Comprehensive Review Of The Long-Term And Short-Term Treatment Of Melasma With A Triple Combination Cream.”  Retrieved from
  2. Bryan.  “Melasma And Post-Inflammatory Hyperpigmentation: Management Update And Expert Opinion.”  Retrieved from
  3. C. B. “Topical Treatments For Melasma And Postinflammatory Hyperpigmentation.” Retrieved from
  4. Aditya K. “The Treatment Of Melasma: A Review Of Clinical Trials.”  Retrieved from

Post by:

Dermatologist Marcela J






Marcella Jiovanni

Skin Care Professional

“Marcella Jiovanni actively promotes the importance of maintaining healthy skin, she envisions the future of dermatology as moving away from pure medical, pharmacological dermatology and flowing more toward a holistic approach to wellness and skincare.”