What is triluma cream? Tri-Luma cream is the only FDA approved treatment method for skin hyperpigmentation which gives positive results within a short period of time like 8 weeks. Skin hyperpigmentation mainly melasma is the main health problem worldwide. Tri-Luma cream has proven its effectiveness by several scientific studies for hyperpigmentation. Tri-Luma cream contains 0.01% of Fluocinolone acetonide, 4% of Hydroquinone, and 0.05% of Tretinoin and manufactured by reputable Galderma Pharma. A lot of triluma cream reviews could be found at a product page on OKDERMO Store.
Skin hyperpigmentation and melasma is one of the main dermatological conditions that mainly affects the female population. It’s less medically and surgically effect for a person’s lifestyle, but there is a huge impact on the psychological aspect of a person. Researches have found that there are women who were unable to perform as previously because of there skin problems. This devastating condition can severely impact people’s quality of life.
Studies have found that ultraviolet radiation, genetics, pregnancy, and hormone replacement therapy contribute to hyperpigmentation. Exposure to UV light can stimulate gene expression of Melanocyte Stimulating Hormone ( MSH ) and Adrenocorticotropic Hormone ( ACTH ). It causes increase melanocyte maturation by stimulating the tyrosinase enzyme. Melanocytes are the skin cells that are responsible for darker skin. That these melanocytes can produce melanin which is the coloring component of the skin.
Studies have found that an increased number of estrogen receptors in hyperpigmented patches and also a high amount of fibroblasts and Vascular Endothelial Growth Factors ( VEGFs ). Thereby researchers are now thinking about pregnancy and using hormone replacement therapy has a direct contribution to hyperpigmentation.
How Tri-Luma cream cure hyperpigmentation ?
Tri Luma cream contains mainly three ingredients which are hydroquinone, fluocinolone, and tretinoin. All of these three components are responsible for curing hyperpigmentation in its own methods.
Hydroquinone is an oxidizing agent which composed of dihydroxybenzene. This compound is structurally similar to precursors of melanin. It inhibits the enzyme tyrosinase. Thereby convention of L 3,4- dihydroxyphenylalanine ( L – DOPA ) to melanin mechanism stops. So melanin production is reduced. Hydroquinone also can damage the cell membranes of the melanocytes and other membranous structures also. These damaged melanocytes eventually die without causing serious damage to the skin.
Hydroquinone 4% is one of the commonest forms available in the market as a treatment for melasma. Studies showed that the regular application of hydroquinone 4% can give better results. There can be seen depigmentation by 5 – 7 weeks of application. And the regular application for three months to one year evident best results from the cream. It is recommended that using sunscreen and topical steroids at the same time gives better results.
Fluocinolone is a corticosteroid that is well known for its reduced inflammatory conditions. Because of the UV radiation and melanocyte activities, there is ongoing inflammation in the surrounding tissues. Because of the inflammation skin appeared as reddish-black which also have a contribution to hyperpigmentation. And also the inflammatory process reduces the effectiveness of other medications we use.
Fluocinolone has anti-inflammatory action. As it’s applied as a topical agent over the lesion it can reduce the surrounding tissue inflammation and facilitates other drug action.
Tretinoin is a pharmacological compound of vitamin A, the retinol. Tretinoin is an FDA approved medication for acne vulgaris and photoaging. Photoaging means skin damage from sunlight. It includes skin hyperpigmentation and skin freckling.
Tretinoin can bind with Retinoid Acid Receptors ( RARs ) alpha, beta, and gamma. RAR receptor activation causes the inflammatory process of the skin. Once tretinoin bound with RAR receptors its activation gets impaired. Thereby the inflammatory process of the associated tissues improved. It improves the production of collagen from procollagen. Collagen is a well known fibrous protein that improves skin condition.
The Tretinoin gamma effect depends on increasing cellular mitosis. Thereby skin cell production improves and cell turn over increases. Because of that skin is able to heal faster than usual. Because the skin is the organ that constantly gets damaged physically and chemically, the improving cell turn overcapacity has a great effect in maintaining skin health.
Tri-Luma cream should apply in the skin as a thin layer. Mainly you should focus on hyperpigmented areas of the skin. It’s better to apply evenly in the whole face for good results. And also regular application of Tri-Luma cream should be advised for rapid improvement within 8 weeks.
How long to stay on triluma cream? Because it contains hydroquinone there is not advisable to use more than 6 months with regular application. But there is a possibility of using the cream for up to one year if you used it thrice a week or only on weekends.
Since Tri-Luma cream contains fluocinolone which is a corticosteroid there is a possibility of affecting pregnancy and breastfeeding. Hypothalamus-pituitary-adrenal ( HPA ) axis can be affected by corticosteroid steroids. Even though the topical application has considerably low systemic absorption it’s better to avoid the application in this period.
Otherwise, there are no proven serious side effects from the Tri-Luma cream. There may be some skin irritations and reddening over the applied areas. These spots get cured once stopping the application for several weeks.
You may be wondering on “how to get triluma cream” OTC? You can buy Tri-Luma cream online in OKDERMO store pharmacy without a prescription. Also, it is available in OKDERMO Skincare online pharmaceutical/cosmeceutical store that you can buy easily. You can order tri luma cream online over the counter via the link – https://okdermo.com/product/triluma-rd-hydroquinone-2-tretinoin-0-025-fluocinolone-0-01-cream-by-galderma-15g/
1. A NEW CORTICOID FOR TOPICAL THERAPY—Fluocinolone Acetonide by Jud R. Scholtz ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574529/ )
2. Tretinoin by Yoham AL, Casadesus D ( https://www.ncbi.nlm.nih.gov/books/NBK557478/#!po=4.68750 )
3. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety by Siddharth Mukherjee, Abhijit Date, […], and Günther Weindl ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/ )
4. Topical treatment of Melasma by Debabrata Bandyopadhyay ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807702/#!po=20.3125 )
5. Hydroquinone by Schwartz C, Jan A, Zito PM ( https://www.ncbi.nlm.nih.gov/books/NBK539693/ )