Semaglutide helps with Appetite and Insulin Regulation

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist which helps with appetite and insulin regulation. It stimulates GLP-1 receptors in the brain, causing the body to feel full after eating lesser quantities of food. It also aids in fat loss by boosting insulin sensitivity, which aids in blood sugar regulation. It is the first FDA-approved medication for chronic weight control in overweight adults or adults with generalized obesity since 2014. [1]

Benefits Of Semaglutide Tablets:

Semaglutide is available as a monotherapy in both subcutaneous and oral tablet forms (it was the first oral GLP-1 receptor agonist to be fully licensed). It is now being studied for anti-obesity reasons after being authorized as a second-line treatment choice to boost glycemic control in type 2 diabetes. Semaglutide is safe in adults and elderly people with renal or hepatic issues that require no dosage change. [2]

Semaglutide Helps Control Type-2 Diabetes:

Studies have shown that it can lower several cardiovascular (CV) risk factors in people with existing CV issues. Semaglutide is well tolerated in monotherapy, with no risk of hypoglycemia, however, it has gastrointestinal side effects. Because a substantial proportion of those infected with COVID-19 was diabetic, the use of Semaglutide in both diabetes and CV patients would be extremely beneficial in maintaining the healthcare system throughout the pandemic. As a result, this peptidic medication is truly important among GLP-1 agonists for the treatment of type 2 diabetes. [2]

Semaglutide Helps In Healthy Weight Loss:

Semaglutide suppresses your appetite and delays digestion, making it easier to stick to a low-calorie diet. It also helps in the reduction of fat deposited in your body, resulting in progressive and healthy weight loss. Unlike other weight loss drugs, which only work while they’re in your system, Semaglutide has been demonstrated to promote long-term weight reduction by assisting you in maintaining a healthy diet and lifestyle even after you stop using it. [3]

GLP-1, a hormone produced from the small intestine, promotes insulin and suppresses glucagon secretions from the pancreatic islets in a glucose-dependent way, resulting in decreased blood glucose levels. GLP-1 has been proven in clinical research to increase satiety, decrease appetite, and reduce calorie consumption. [4[

The most recent research plan looked at the safety and efficacy of subcutaneous Semaglutide, which has 94% similarity to endogenous GLP-1. A fatty diacid chain added at position 26 increases albumin binding. The substitution of alanine for aminoisobutyric acid at position 8 reduces the molecule’s susceptibility to dipeptidyl peptidase breakdown. These changes have improved the molecule’s half-life, allowing subcutaneous Semaglutide to be injected once weekly. [3]

Semaglutide Promotes Metabolic Health:

Semaglutide, in addition to aiding in weight loss, lowers your risk of developing type-2 diabetes by enhancing your body’s capacity to use insulin, as well as decreasing inflammation and cholesterol levels. [4]

According to one study, the fasting appetite suppression was enhanced with Semaglutide versus placebo, whereas nausea ratings were equivalent. Semaglutide was linked to decreased appetite and food cravings, improved eating control, and a lower desire for high-fat diets. The resting metabolic rate did not change across treatments when addressed for lean body mass. Semaglutide resulted in a 5.0 kg decrease in mean body weight from baseline, primarily from body fat mass. [4]

Dosing of Semaglutide Tablets:

Follow the instructions from your physician or the directions on the label. This data only includes the normal dosages of this drug. The amount of medicine you take is determined by the potency of the drug. In addition, the number of dosages you take each day, the duration between doses, and the time you take the drug are all determined by the medical issue for which you are using the medicine.

In the case of type-2 diabetes:

• For oral administration (tablets):

Adults—For the first 30 days, take 3 milligrams (mg) once a day.

As needed, your doctor may change your dosage. However, the dosage is normally limited to 14 mg once per day. Your doctor will decide the appropriate use and dosage for you.

How To Use Semaglutide Tablets:

Before you begin taking Semaglutide, and each time you get a refill, read the Medication Guide provided by your pharmacist. As instructed by your doctor, take this medicine with a sip of plain water (no more than 4 ounces or 120 milliliters) once a day. It should not be combined with any other beverage. Take the pill whole. The pill should not be split, chewed, or crushed.

• Wait for at least 30 minutes following having Semaglutide before eating or drinking anything other than water or taking any other medicine orally.
• You should eat 30 to 60 minutes after taking Semaglutide for good results. It is crucial to take this medication in the same way with each dose.
• The dosage is determined by your medical condition as well as how you respond to treatment.
• To limit the possibility of adverse effects, your doctor may advise you to begin this medicine at a low dose and gradually increase it. Follow your doctor’s advice properly.

Don’t increase your dose or take this medication more frequently or for a longer period than recommended. Your condition will not improve faster, and your chances of experiencing negative effects will increase. Inform your doctor if your medical condition does not improve or worsen (your blood sugar level is too elevated or too low).

Precautions:

Your doctor must monitor your progress at regular times to ensure that this medication is working appropriately. To rule out any negative effects, blood and urine testing may be necessary.

Inform your doctor if you are pregnant or intend on becoming pregnant. Do not use this medication for at least two months before trying to conceive. It is crucial that you carefully follow any directions given to you by your healthcare team regarding:

• Alcohol use can result in extremely low blood sugar levels. Consult your medical team about this.
• Other medicines—Do not take any other drugs while using Semaglutide unless your doctor has permitted them. This includes nonprescription medications like aspirin, as well as medications for appetite control, asthma, colds, cough, hay fever, or sinus issues.

Counseling—Other family members must learn how to prevent or manage side effects if they arise. Diabetic patients may also require further counseling on diabetes medication dose adjustments that may occur as a result of lifestyle changes, such as changes in activity and diet.

References:

1. (n.d.). 5 Benefits Of Semaglutide For Weight Loss. Retrieved from reliefbeginshere.com: https://reliefbeginshere.com/5-benefits-of-semaglutide-for-weight-loss/
2. (n.d.). Semaglutide, A Glucagon Like Peptide-1 Receptor Agonist With Cardiovascular Benefits For Management Of Type 2 Diabetes. Retrieved from nih.gov: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736331/
3. (n.d.). Wegovy (Semaglutide): A New Weight Loss Drug For Chronic Weight Management. Retrieved from nih.gov: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717485/
4. (n.d.). Effects Of Once-Weekly Semaglutide On Appetite, Energy Intake, Control Of Eating, Food Preference And Body Weight In Subjects With Obesity. Retrieved from dom-pubs.onlinelibrary.wiley.com: https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.12932#:~:text=Semaglutide%20was%20associated%20with%20less,did%20not%20differ%20between%20treatments
5. (n.d.). Semaglutide Tablets. Retrieved from my.clevelandclinic.org: https://my.clevelandclinic.org/health/drugs/21291-semaglutide-tablets#:~:text=SEMAGLUTIDE%20(SEM%20a%20GLOO%20tide,often%20combined%20with%20this%20medication.
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