What is Voriconazole Verz® | Vfend Generic
Verz tablets manufactured by reputable Dr.Reddy’s Labs. Verz contains Voriconazole 50mg or 200mg, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. Verz Voriconazole is used to treat a variety of fungal infections. It belongs to a class of drugs known as azole antifungals.
It works by stopping the growth of fungi. Azole antifungals are a group of medicines that contain an azole ring and inhibit the growth of a wide range of fungi. They are classified into two groups: those with two nitrogens in the azole ring (the imidazoles; examples include clotrimazole, econazole, ketoconazole, miconazole, and tioconazole) and those with three nitrogens in the azole ring (the triazoles; examples include fluconazole, itraconazole, posaconazole, and voriconazole).
Azole antifungals work by inhibiting the cytochrome P450 dependent enzyme lanosterol 14-alpha-demethylase, which converts lanosterol to ergosterol, the main sterol in the fungal cell membrane. Depletion of ergosterol damages the cell membrane resulting in cell death. Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete’s foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.
What is Aspergillosis?
Aspergillosis is the name given to a wide variety of diseases caused by fungal infections from species of Aspergillus. Aspergillosis occurs in humans, birds, and other animals. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in people with severely compromised immune systems, e.g. those undergoing bone marrow transplantation. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses, such as asthma, cystic fibrosis, sarcoidosis, tuberculosis, or chronic obstructive pulmonary disease. Most commonly, aspergillosis occurs in the form of chronic pulmonary aspergillosis (CPA), aspergilloma, or allergic bronchopulmonary aspergillosis (ABPA). Some forms are intertwined; for example, ABPA and simple aspergilloma can progress to CPA.
Other, noninvasive manifestations include fungal sinusitis (both allergic in nature and with established fungal balls), otomycosis (ear infection), keratitis (eye infection), and onychomycosis (nail infection). In most instances, these are less severe, and curable with effective antifungal treatment. The most frequently identified pathogens are Aspergillus fumigatus and Aspergillus flavus, ubiquitous organisms capable of living under extensive environmental stress. Most people are thought to inhale thousands of Aspergillus spores daily but without effect due to an efficient immune response. Taken together, the major chronic, invasive, and allergic forms of aspergillosis account for around 600,000 deaths annually worldwide.
How to use Voriconazole Verz® | Vfend Alternative
- Read the leaflet is available from your doctor before you start taking voriconazole and each time you get a refill. If you have any questions, ask your doctor.
- Take this medication by mouth without food (at least 1 hour before or 1 hour after meals) as directed by your doctor, usually every 12 hours.
- The dosage and length of treatment are based on your medical condition, response to treatment, and other medications you may be taking.
- Be sure to tell your doctor about all the products you use.
- For the best effect, take this antifungal at evenly spaced times. To help you remember, take this medication at the same time every day.
- Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days.
- Stopping the medication too early may result in a return of the infection.
Side effects of Voriconazole
- Nausea/vomiting and headache may occur. If any of these effects last or get worse, tell your doctor promptly.
- Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
- Tell your doctor right away if you have any serious side effects, including vision changes (such as blurred vision, color vision changes), the sensitivity of eyes to light (photophobia), eye pain, signs of kidney problems (such as a change in the amount of urine), bone/joint pain, mental/mood changes (such as hallucinations).
- Get medical help right away if you have any very serious side effects, including fast/irregular heartbeat, severe dizziness, fainting.
- Voriconazole has rarely caused very serious (possibly fatal) liver disease. Tell your doctor right away if you develop symptoms of liver disease, such as nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.
- A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
- Voriconazole can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Get medical help right away if you develop any rash.