Description
Tranexamide Forte Serum is a potent, clinical-grade formulation in a 30 ml dropper bottle, designed to target the root causes of uneven pigmentation, melasma, and photo-aging. By combining 5 % tranexamic acid with niacinamide, mulberry extract, and other skin-beneficial compounds, this serum delivers a multi-modal approach to brighten skin tone, reduce dark spots, and promote collagen synthesis. Comprehensive clinical studies support its efficacy and safety, making it a staple in both professional dermatology practices and home care routines.
Mechanism of Action
Tranexamic acid, a synthetic derivative of the amino acid lysine, functions by inhibiting plasminogen activation and subsequent plasmin activity in keratinocytes. This blocks the UV-induced release of arachidonic acid and prostaglandins that upregulate melanogenesis, thereby reducing melanin production at its source Clinical efficacy study . Additionally, niacinamide supports barrier function and inhibits the transfer of melanosomes to keratinocytes, further preventing pigment accumulation Barrier enhancement research .
Key Ingredients & Formulation
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Tranexamic Acid (5 %): Core brightening agent; clinically proven to lighten melasma and post-inflammatory hyperpigmentation with minimal irritation Topical tranexamic review .
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Niacinamide (Vitamin B3): Strengthens the stratum corneum, reduces TEWL, and blocks melanosome transfer, contributing to even tone and enhanced barrier resilience Niacinamide benefits .
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Mulberry (Morus alba) Extract: Rich in arbutin and flavonoids; offers antioxidant protection against UV-induced pigment production Antioxidant profile of mulberry .
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Hyaluronic Acid: Delivers multi-molecular weight hydration, plumping fine lines and enhancing ingredient penetration.
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pH-Balanced Base (pH 5.5): Optimizes tranexamic acid stability and skin compatibility.
Clinical Evidence
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Melasma Reduction: In a double-blind trial, topical tranexamic acid at 3 %–5 % demonstrated a 60 % average reduction in Melasma Area and Severity Index (MASI) scores over 12 weeks MASI clinical trial .
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Post-Inflammatory Hyperpigmentation: Patients with PIH showed 45 % spot lightening after 8 weeks of 5 % tranexamic acid serum application, with minimal adverse reactions PIH study .
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Collagen Stimulation: Combined use of niacinamide and tranexamic acid increased dermal collagen markers by 25 % in ex vivo studies, improving firmness and reducing fine lines Collagen research .
Indications & Skin Concerns
Tranexamide Forte Serum is ideal for:
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Melasma: Inhibits UV-driven melanogenic pathways.
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Hyperpigmentation & Dark Spots: Prevents melanosome transfer and reduces existing pigment.
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Uneven Skin Tone & Dullness: Exfoliates gently and promotes cell turnover.
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Photo-Aging & Fine Lines: Hydrates deeply and supports collagen synthesis.
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Post-Acne Marks & Scars: Lightens residual erythema and PIH.
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Sun Damage & Discoloration: Neutralizes free radicals and repairs barrier function.
Usage & Application
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Cleanse: Use a gentle, pH-balanced cleanser.
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Tone (Optional): Apply alcohol-free toner to prep the skin.
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Serum: Dispense 3–4 drops onto fingertips; apply evenly to face, neck, and décolleté.
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Moisturize: Follow with a hydrating moisturizer to lock in actives.
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Sun Protection: In the morning, complete with a broad-spectrum SPF 30+ to prevent UV-induced pigmentation rebound SPF importance .
Frequency: Twice daily. If sensitivity occurs, reduce to once daily or alternate days. Visible improvement typically occurs within 4–8 weeks of consistent use.
Suitability & Skin Types
#Normal/Combo: Balances hydration without greasiness.
Suitable for most skin types except highly sensitive or barrier-compromised. Perform a patch test if you have known sensitivities to acids or botanical extracts.
Safety & Tolerability
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pH 5.5 ensures minimal irritation.
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Non-comedogenic: Won’t clog pores.
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Allergy Control: Free from fragrance, mineral oil, and alcohol.
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Clinical Tolerance: Over 90 % of trial participants reported no adverse events.
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Contraindications: Avoid during pregnancy and lactation unless advised by a dermatologist Pregnancy guidelines .
Storage & Stability
Store in a cool, dark place away from direct sunlight. Replace cap securely after each use to maintain potency.
Why Choose Tranexamide Forte Serum?
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Science-Backed: Proven in peer-reviewed trials.
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Multi-Modal: Combines brightening, barrier repair, and hydration.
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Professional Grade: Formulated to clinical standards.
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High Bioavailability: Optimal pH and molecular delivery.
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Visible Results: Noticeable improvements in tone, texture, and clarity.
References
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Clinical efficacy study of tranexamic acid in melasma: PubMed ID 23926438
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Barrier enhancement research on niacinamide: PMC ID 2921756
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Topical tranexamic acid review: PubMed ID 32579600
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MASI clinical trial: PubMed ID 24859356
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PIH study: PubMed ID 31227117
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Collagen research: PMC ID 4327185
FAQ
What is Tranexamide Forte Serum?
Tranexamide Forte Serum is a clinical-grade topical treatment containing 5 % tranexamic acid, niacinamide, and botanical extracts to reduce pigmentation and improve skin tone.
How does tranexamic acid work?
Tranexamic acid inhibits UV-activated plasmin production in the epidermis, diminishing signals that trigger melanin synthesis.
How soon will I see results?
Most users observe visible lightening of dark spots and improved uniformity within 4–8 weeks of consistent twice‐daily application.
Can I use it with other actives?
Yes. It pairs well with vitamin C, retinoids, and SPF. Introduce new actives gradually and monitor for tolerance.
Is it safe during pregnancy?
Topical tranexamic acid’s safety in pregnancy is not fully established; consult your healthcare provider before use.
How should I layer this serum in my routine?
Apply after cleansing (and toning, if used) but before moisturizer. Always follow with SPF in the morning.
