What is Pynomax-Tx® Anti Melasma Cream
Pynomax-TX Cream is a specially formulated anti-melasma cream based on modern dermatological and biotechnological science research and contains SPF-50 protector, Extract of Liquorice Root, Tranexamic Acid, Niacinamide, Allantoin, Arbutin, Kojic Acid, Ginseng Extract as the main active ingredients. For external use only, read the label carefully before use, keep out of the reach and sight of children. The cream manufactured and researched by Galcare Pharmaceutical, a reputable company with an innovative way and touch to science and research.
Licochalcone is a molecule contained in Liquorice root extract which helps control oil production and is anti-bacterial as well as an anti-inflammatory in action, it helps to control oil production from the skin. Licorice root extract contains antioxidants – glabridin and licochalcone A. Both have anti-aging and skin-soothing properties. Liquiritin, a flavonoid component of licorice which has depigmenting properties. Licochalcone protects the skin against the damaging effects of UV radiation by strengthening the skin’s own defense system. It also regulates sebum production which makes it ideal for oily skin. It has anti-inflammatory and anti-bacterial properties.
Tranexamic Acid offers excellent anti-plasmin activity. Works on all pathogenic mechanisms in melasma. The onset of action in 4 weeks. Total improvement rate for melasma is 95.9%. Recurrence in only 9.5% cases and effectively treated with repeat applications.
Tranexamic acid exerts effects on pigmentation via its inhibitory effects on UV light-induced plasminogen activator and plasmin activity. UV radiation induces the synthesis of plasminogen activator by keratinocytes, which results in increased conversion of plasminogen to plasmin. Plasminogen activator induces tyrosinase activity, resulting in increased melanin synthesis. The presence of plasmin results in increased production of both arachidonic acid and fibroblast growth factor, which stimulate melanogenesis and neovascularization, respectively. By inhibiting plasminogen activation, tranexamic acid mitigates UV radiation-induced melanogenesis and neovascularization. In treated guinea pig skin, application of topical tranexamic acid following UV radiation exposure inhibited the development of expected skin hyperpigmentation and also reduced tyrosinase activity.
Kojic Acid act as a depigmenting agent. Kojic acid is a compound that is commonly derived from various fungi. Kojic acid is often used as a skin-lightening agent because of its effects on a protein known as tyrosinase. Kojic acid works by preventing a specific function of tyrosinase called its catecholase function. The important thing to understand about the catecholase function is that it is the most important step in making the compound melanin. Melanin is the primary pigment in the skin. Thus, by inhibiting the tyrosinase protein’s ability to make melanin, kojic acid is able to prevent skin pigmentation, which can help lighten the skin’s tone.
Niacinamide is also known as vitamin B3 and nicotinamide, niacinamide is a water-soluble vitamin that works with the natural substances in your skin to help visibly improve enlarged pores, uneven skin tone, fine lines and wrinkles, dullness, and a weakened surface.
Niacinamide also reduces the impact of environmental damage because of its ability to improve skin’s barrier (its first line of defense), plus it also plays a role in helping the skin to repair signs of past damage. Left unchecked, this type of daily assault makes skin appear older, dull, and less radiant.
Allantoin is lab-created allantoin is chemically equivalent to its naturally-occurring counterpart, and has been shown to be non-toxic and safe for use in a variety of cosmetic applications (International Journal of Toxicology). In its organic form, allantoin is found in several plants, such as sugar beet, comfrey, chamomile, tobacco seed, and wheat sprouts. A popular source of allantoin is the extract of comfrey, a species of herb native to Europe. Interestingly, it is named for the allantois, a structure involved in the exchange of nutrients and waste for developing embryos.
Arbutin is a Glucosylatedhydroquinone, derived from the leaves of fruits such as bearberry, pear, and cranberry. A natural skin lightening/whitening agent. It works by slowly releasing hydroquinone through hydrolysis, which in turn blocks Tyrosinase activity and reduces the skin’s melanin (pigmentation) production.
Ginseng Extract – hyperpigmentation is no match for ginseng, as it helps inhibit melanin production. Antioxidants in ginseng come into play here once again. Environmental pollutants can easily be absorbed through the skin, accumulate in pores, and stimulate melanocytes, thereby creating brown spots. But ginseng acts as a shield against them. These same antioxidants also help balance oil production. And if sensitive skin is your worry, ginseng’s natural anti-inflammatory properties help quell redness and puffiness. It can even be a good, calming remedy for skin conditions such as acne and psoriasis because of this.