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Tiniba® Tinidazole Tablets

Tinidazole 500mg

USD $34.00

Tinidazole is used to treat infections caused by protozoa (eg, trichomoniasis, giardiasis, and amebiasis). It is also used to treat adult women with vaginal infections (bacterial vaginosis).

Tinidazole belongs to the group of medicines called antiprotozoals. These medicines are used to treat infections caused by protozoa (tiny, one-celled animals).

Size: 30 Tablets
Brand name: Tindamax
Title Range Discount
Items: 2 - 4 5%
Items: 5 - 8 10%
Items: 9 + 15%

Description

Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.

Tiniba® Tinidazole Tablet is an antibiotic medicine that helps your body fight infections caused by bacteria and parasites. It is used to treat infections of the liver, stomach, intestines, vagina, brain, heart, lungs, and skin.

Tiniba® Tinidazole Tablet is also used in the treatment of dental infections, leg ulcers, and pressure sores. This medicine should be taken with food, at the same time each day to get the most benefit. The amount you are advised will depend on what you are being treated for and how bad it is, but you should take this antibiotic exactly as prescribed by your doctor. Your symptoms may get better after a short time but do not stop taking it until you have finished a full course of treatment, even if you feel well. If you stop taking it early, some bacteria may survive, and the infection may come back. Do not drink any alcohol while taking this medicine and for some days after stopping it. Otherwise, you may get unpleasant side effects like nausea, vomiting, and stomach pain.

The most common side effects of this medicine are headache, dryness in the mouth, nausea, and a slight metallic taste in the mouth. These are usually mild but let your doctor know if they bother you or last more than a few days. You can try using sugarless candies or lozenges to overcome any dryness or metallic taste in the mouth.

Before using this medicine, inform your doctor if you are allergic to any medicine or have any kidney or liver problems or any disease of the nervous system. This medicine should not be taken if you are pregnant or breastfeeding unless it is absolutely necessary and prescribed by your doctor.


Tinidazole: Overview

Tinidazole is a broad-spectrum antimicrobial agent belonging to the nitroimidazole class of antibiotics. It is structurally similar to metronidazole but offers a longer half-life, fewer gastrointestinal side effects, and improved tolerability. Tinidazole is used for treating protozoal infections, anaerobic bacterial infections, and certain sexually transmitted diseases (STDs).

Tinidazole works by disrupting the DNA of infectious organisms, leading to their death. It is effective against various parasitic and bacterial infections, particularly those caused by anaerobic bacteria and protozoa.

This medication is available in tablet and intravenous (IV) formulations, making it suitable for both oral and hospital-based treatments.


On-Label Uses of Tinidazole (FDA-Approved Uses)

1. Protozoal Infections

Giardiasis (Giardia lamblia infection)

  • Tinidazole is highly effective against Giardia, a parasite causing diarrhea, abdominal cramps, bloating, and weight loss.
  • Often given as a single-dose treatment, making it more convenient than metronidazole, which requires multiple doses over several days.

Amebiasis (Entamoeba histolytica infection)

  • Used to treat intestinal and extraintestinal (liver abscess) amebiasis.
  • Particularly beneficial for liver abscesses, as it reaches high tissue concentrations.

Trichomoniasis (Trichomonas vaginalis – STD)

  • Treats trichomoniasis, a common sexually transmitted infection (STI) that causes vaginal discharge, irritation, and discomfort in women and urethritis in men.
  • Given as a single-dose oral treatment, making it more convenient than multi-day metronidazole therapy.
  • Both partners must be treated simultaneously to prevent reinfection.

2. Anaerobic Bacterial Infections

Tinidazole is effective against anaerobic bacteria, commonly used for:

Bacterial Vaginosis (BV)

  • Often prescribed for BV treatment due to its longer duration of action compared to metronidazole.
  • Helps restore the balance of vaginal flora by eliminating anaerobic bacteria.

Pelvic Inflammatory Disease (PID)

  • Used in combination with other antibiotics to treat severe gynecological infections.

Intra-abdominal Infections (Peritonitis, Abscesses)

  • Effective for peritonitis and abdominal abscesses, often in combination with beta-lactam antibiotics.

Periodontal and Dental Infections

  • Used for dental abscesses, gum infections, and post-surgical infections involving anaerobic bacteria.

Clostridium difficile Infection (C. diff colitis) (Off-Label Use)

  • Occasionally used for mild-to-moderate C. difficile infections, although vancomycin or fidaxomicin are preferred first-line treatments.

Off-Label Uses of Tinidazole

Helicobacter pylori Eradication (Stomach Ulcers)

  • Used in triple or quadruple therapy regimens for H. pylori-associated ulcers, particularly in metronidazole-resistant cases.

Lyme Disease (Persistent or Refractory Cases)

  • Sometimes used as part of combination therapy for chronic Lyme disease, particularly to target cystic and biofilm forms of Borrelia.

Bacterial Prostatitis (Chronic Pelvic Pain Syndrome – CPPS)

  • Some studies suggest benefits in chronic prostatitis, especially cases involving anaerobic bacteria.

Rosacea (Demodex Mite-Associated Cases)

  • Used to reduce inflammation and Demodex mite overgrowth in rosacea patients.

Why Tinidazole is Beneficial

  • Single-Dose Therapy for Protozoal Infections – Easier and more convenient than multi-day regimens.
  • Longer Half-Life (12-14 Hours) – Requires fewer doses than metronidazole, improving compliance.
  • Fewer Gastrointestinal Side Effects – Less nausea, vomiting, and metallic taste compared to metronidazole.
  • Broad-Spectrum Activity – Covers anaerobic bacteria, protozoa, and some STDs.
  • Tissue Penetration – Effective for infections in the liver, GI tract, reproductive organs, and oral cavity.
  • High Cure Rates for Trichomoniasis and BV – More effective than metronidazole for some resistant cases.

Precautions & Warnings

1. Contraindications

  • Hypersensitivity to Tinidazole or Nitroimidazole Derivatives
  • First Trimester of Pregnancy – Can cross the placenta and affect fetal development.
  • Breastfeeding – Avoid during breastfeeding; wait 72 hours after the last dose before resuming.
  • Severe Liver Disease – Use with caution as metabolism is affected.

2. Warnings & Precautions

  • Neurological Side Effects (Rare but Serious)
    • Dizziness, peripheral neuropathy (numbness, tingling), seizures, and headaches can occur with prolonged use.
  • Gastrointestinal Side Effects
    • Nausea, vomiting, diarrhea, and metallic taste are possible, though less common than with metronidazole.
  • Alcohol Interaction (Disulfiram-Like Reaction)
    • Avoid alcohol for at least 72 hours after the last dose to prevent severe nausea, vomiting, flushing, and headache.
  • Blood Disorders (Rare)
    • Long-term use may cause mild leukopenia (low white blood cells), requiring blood monitoring.
  • Potential Drug Interactions
    • Warfarin (Blood Thinner): Tinidazole can increase bleeding risk; dose adjustment may be needed.
    • Lithium: May increase lithium toxicity.
    • Immunosuppressants (e.g., Tacrolimus, Cyclosporine): May require dose monitoring.

Frequently Asked Questions (FAQ)

1. How does Tinidazole work?
Tinidazole enters bacterial and protozoal cells, disrupts their DNA, and kills the organisms.

2. How is Tinidazole taken?

  • For giardiasis, trichomoniasis, and BV: Single-dose treatment (2g).
  • For amebiasis: Taken for 2-3 days (intestinal infections) or 5-10 days (liver abscesses).
  • For anaerobic bacterial infections: Usually 5-7 days of treatment.
  • Best taken with food to reduce stomach upset.

3. How long does it take for Tinidazole to work?

  • For trichomoniasis and giardiasis: Symptoms improve within 24-48 hours.
  • For amebiasis or bacterial infections: Improvement occurs in 2-5 days.

4. Can I drink alcohol while taking Tinidazole?
No. Drinking alcohol can cause severe nausea, vomiting, flushing, and headache (disulfiram-like reaction).

  • Avoid alcohol for 72 hours after the last dose.

5. Is Tinidazole safer than Metronidazole?

  • Yes, in some cases. Tinidazole has fewer gastrointestinal side effects and requires fewer doses.
  • However, both drugs are highly effective and used interchangeably.

6. Can pregnant or breastfeeding women take Tinidazole?

  • Not safe in the first trimester of pregnancy.
  • Breastfeeding should be avoided for 72 hours after the last dose.

7. What should I do if I miss a dose?

  • Take the missed dose as soon as possible.
  • If close to the next dose, skip the missed dose and continue the regular schedule.

Conclusion

Tinidazole is a highly effective, well-tolerated, and long-acting antibiotic and anti-protozoal agent. It is especially beneficial for single-dose treatments of trichomoniasis, giardiasis, and bacterial vaginosis. With fewer side effects and better compliance than metronidazole, Tinidazole is a preferred choice for many infections.

Consult a healthcare provider before use, especially if pregnant, breastfeeding, or taking other medications.

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