What is Rifagut® Rifaximin Tablet?
Rifaximin is a non-absorbable, broad-spectrum antibiotic mainly used to treat travelers’ diarrhea. It is based on the rifamycin antibiotics family. Since its approval in Italy in 1987, it has been licensed in more than 30 countries for the treatment of a variety of gastrointestinal diseases like irritable bowel syndrome, and hepatic encephalopathy. It acts by inhibiting RNA synthesis in susceptible bacteria by binding to the RNA polymerase enzyme. This binding blocks translocation, which stops transcription. It is marketed under the brand name Xifaxan by Salix Pharmaceuticals.
Rifaximin is an antibiotic indicated for the treatment of patients 12 years of age and older with travelers’ diarrhea caused by noninvasive strains of Escherichia coli (E. coli), and to lower the risk of worsened brain function, or hepatic encephalopathy, in adults with liver failure.
- 2 weeks of Rifaximin provided significant relief in adults with IBS-D
- Up to 6 months of relief from abdominal pain and diarrhea
- #1 doctor prescribed medication approved for IBS-D
- Recommended by the American College of Gastroenterology
In a clinical trial: average of 10 weeks; the range of 6 to 24 weeks of relief from abdominal pain and diarrhea. You can be retreated up to 2 times if symptoms return. The American College of Gastroenterology has given Rifaximin a strong recommendation to treat global IBS-D symptoms. This is based on a moderate level of clinical trial data.
Rifagut® Rifaximin Tablet is an antibiotic that treats hepatic encephalopathy, a condition in which the liver fails to remove harmful toxins from the blood, leading to brain damage. Symptoms include agitation, confusion, muscle problems, difficulty in speaking, and sometimes, coma.
Rifagut® Rifaximin Tablet is also used to treat infectious diarrhea and irritable bowel syndrome with diarrhea (IBS-D) in adults and children. This medicine can be used alone or in combination with other medicines. It may be taken with or without food, preferably at the same time, each day. It should be used in the dose and duration as advised by the doctor. Take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection come back and harder to treat.
Some people may develop side effects like vomiting, headache, dizziness, and nausea. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away. Your urine may become reddish in color due to this medicine. But, it is normal and harmless.
Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding, or suffering from any liver, kidney, or heart problems or if you are allergic to any medicine.
Rifaximin has a well-established Safety Profile:
- NOT a controlled substance
- NOT contraindicated in patients without a gallbladder
- No association of pancreatitis was observed in patients taking Rifaximin in the clinical trials
Rifaximin is an antibacterial medication, or antibiotic, that did not cause any clinically relevant antibiotic resistance after 1 to 3 treatment cycles. If you take antibiotics, like Rifaximin, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.
How Rifaximin Works
The exact cause of IBS-D is unknown. However, it is believed that an imbalance in gut bacteria may be linked to IBS-D symptoms. Rifagut® Rifaximin Tablets work mainly in the gut to inhibit the growth of bacteria. Talk to your healthcare provider before taking Rifagut® Rifaximin Tablets if you have a severe hepatic (liver) impairment, as this may cause increased effects of the medicine.
In Treatment of Hepatic encephalopathy. Hepatic encephalopathy is a severe liver disease that can cause changes in brain function leading to confusion, tremors (shaking), sleep problems, and loss of consciousness. Rifagut® Rifaximin Tablet lowers the levels of ammonia-producing bacteria in the blood which has harmful effects on the brain. If taken as prescribed, this medicine can improve your brain function and reduce symptoms associated with hepatic encephalopathy.