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Melrio® Skin Whitening Cream

Hydroquinone 2% + Tretinoin 0.025% + Fluticasone Propionate 0.05%

(3 customer reviews)

USD $24.00

Melrio Cream is used to lighten dark spots and pigmentation, melasma. Melrio Cream works to inhibit the synthesis of melanin, melanin causes dark pigmentation. Melrio Cream can also be used to reduce scars.

Melrio Cream contains Hydroquinone Topical, Fluticasone propionate, and Tretinoin as ingredients. Melrio cream works by inhibiting the enzyme tyrosinase and increases the turnover of follicular epithelial cells.

Melrio cream has anti-inflammatory properties, shows anti-pruritic activities, used for melasma, and reduces age spots

Indications: Melasma, Acne Spots, Age Spots, Light brown color patches on the skin.

Size: 20g / 0.7oz
Brand name: Tri-Luma
Title Range Discount
Items: 2 - 4 5%
Items: 5 - 8 10%
Items: 9 + 15%


What is Melrio® Cream?

This combination of medication in Melrio cream is used to treat melasma on the face. Melasma is a condition of dark patchy areas on the skin, especially on the cheeks and forehead. It sometimes occurs with hormone changes. This product contains 3 different kinds of medication. Hydroquinone is a reversible skin bleaching agent. Tretinoin is a retinoid that increases skin shedding. Fluocinolone is a medium-strength corticosteroid that reduces swelling, itching, and redness. This medication may improve your melasma, but it is not a cure. Continued exposure to some of the causes of melasma (e.g., sunlight, estrogen-type birth control hormones) may cause it to return.

Melrio is generic to Tri-Luma cream that is designed for topical treatment of dark and brown spots, melasma, and freckles. Melrio provides faster results (6-8 weeks). Melrio cream same as Tri-Luma cream should always be used in accordance with the instructions of your doctor. Melrio cream is a combination of three complementary active agents:

  • Depigmenting agent (2% hydroquinone) – blocks the melanin, and evens skin tone. Hydroquinone Topical is used in the treatment of hyperpigmentation and melasma. Hydroquinone is known as a melanin synthesis inhibitor. Hydroquinone Topical works by bleaching the skin by reducing the accumulation of skin pigment called melanin that causes darkening of the skin.
  • Derivatives of vitamin A (tretinoin 0.025%) – renews and protects the skin. Tretinoin Topical is used in the treatment of acne breakouts, to smooth rough facial skin, and to reduce the appearance of fine wrinkles and mottled skin discoloration. Tretinoin is a form of vitamin A that helps the skin renew itself. Tretinoin topical works by slowing the production of certain natural substances that can cause acne.
  • Anti-inflammatory component (fluticasone propionate 0.05%) – helps to heal the skin, reducing the inflammation. Fluticasone Propionate topical is used to reduce inflammation and relieve itching, redness, dryness, and scaling associated with various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes). Fluticasone is in a class of medications called corticosteroids. It works by activating natural substances in the skin to reduce swelling, redness, and itching.

Contraindications when using Melrio® Cream

  • pregnancy and lactation;
  • acute inflammation (including eczema) lesions of the skin (dermatitis, seborrhea, and others.);
  • rosacea;
  • skin lesions (wounds, burns, etc.);]
  • photosensitivity;
  • diseases of the rectum, of liver or kidney, Addison’s disease;
  • asthma, allergic to sulfites, or to any of the components of the cream;
  • hypersensitivity to any component of the cream (discontinue use and consult a doctor if you have any of these symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, tongue, or throat).

In controlled clinical trials, the most frequently reported side effects such as: redness, peeling, burning, dryness and itching at the site of application.

Discontinue use of Melrio® Cream and notify your doctor if you have any of the following side effects:

  • darkening of the treated skin;
  • strong irritation of the skin;
  • the formation of bubbles;
  • dribbling, scaling or crusting;
  • painful burning or swelling of the skin;
  • any type of breathing problems;


  • Hydroquinone USP 20mg
  • Tretinoin USP 0.25mg
  • Fluticasone Propionate IP 0.50mg
  • Cream base q.s.
  • Methylparabem IP 0.18% w/w
  • Propylparaben IP 0.02% w/w