What is Duovir N® Tablet?
Lamivudine 150mg + Zidovudine 300mg + Nevirapine 200mg – the combination of such drugs is not commercially available in the United States. Duovir N® Tablets are a mixture of three active ingredients called Lamivudine, Nevirapine and Zidovudine. Duovir N tablets are mainly used among HIV-infected patients.
Duovir N® Tablet is a combined medication containing three active ingredients known Lamivudine, Nevirapine, and Zidovudine. Duovir N tablets are used to suppress HIV replication within HIV-infected patients. Other than that Duovir tablets can elevate the amount of CD4 cells. CD4 cells are a type of leucocyte that can protect our body from various infections.
- Lamivudine is a reverse transcriptase inhibitor and belongs to the synthetic nucleoside analogue. Lamivudine inhibits the action of the reverse transcriptase enzyme, and it leads to the termination of the viral DNA chain.
- Zidovudine is also a synthetic form of nucleoside analogue. Within the cells, Zidovudine gets phosphorylated and get converted to its active metabolite. The active metabolite of Zidovudine inhibits the action performed by the reverse transcriptase enzyme. Therefore this process helps end the DNA chain formation within the virus replication.
- Nevirapine is a non-nucleoside but also belongs to reverse transcriptase inhibitors. When Duovir N enters the bloodstream, the Nevirapine within the medication will directly bind with the reverse transcriptase enzyme of the HIV. As a result, the RNA and DNA-dependent polymerase activities get disturbed.
How to use Duovir N Tablets
Duovir tablets are taken orally with water. It is recommended to take the Duovir tablets with an empty stomach. To mask the side effects, it is preferred to use the Duovir tablets close to bedtime. Do not skip any dose because mal use of antivirals can result in treatment failure. So it is essential to use the correct amount at the right time.
Side effects of Lamivudine/Zidovudine 300mg/Nevirapine 200mg
When a patient uses Duovir tablets for the first time, they will experience a few common side effects such as nausea, diarrhea, headache, fatigue, sleeping problems, skin rashes, and myalgia. With time Duovir tablets can alleviate the number of red blood cells and white blood cells within the bloodstream. So make sure to check a full blood count regularly.
- Zidovudine can induce hematological toxicity. So there is a risk of becoming anemic and experiencing lower white blood cells when using Duovir tablets for a prolonged period. Therefore make sure to check the hematological status periodically.
- There is a risk of turning the bone marrow into compromised status.
- Zidovudine can result in myositis and damage the skeletal muscles.
- Nucleoside analogues increase the risk for lactic acidosis and hepatomegaly. Being a female and being over-weighted increases the risk further. Therefore it is essential to be alert regarding lactic acidosis and hepatomegaly.
- There is a risk of worsening the condition after the termination of the Duovir tablets. Therefore monitoring and medical advice are necessary to continue for several months.
- Lamivudine must be used with precautions if the patient has a history of pancreatitis.
- Immune reconstitution syndrome is rare but can be present when using combined antiretroviral therapy. Be cautious if you experience symptoms of autoimmune conditions.
- Monitor your liver function to make sure that the liver is performing well.
- Avoid consuming alcohol with Duovir tablets because Duovir and alcohol can damage the hepatic organs.
- Duovir tablets are not teratogenic. Therefore can be used successfully during the pregnancy period. As pregnancy is always considered a risky condition, discuss it further with the physician.
- If you are a breastfeeding mother, make consultations with the physician before deciding.
- Duovir tablets may make you feel dizzy. Therefore never engage in activities that need concentration like driving and machine operation.