What is Medroxyprogesterone Acetate Injection?
Medroxyprogesterone Acetate Injection contains an injectable synthetic hormone that behaves like the natural hormone progesterone. This hormone stops you from getting pregnant in multiple ways. Firstly, it prevents an egg from being released from your ovaries. Secondly, it makes the fluid (mucus) in your cervix thicker, which makes it more difficult for sperm to enter the womb. Additionally, it prevents the thickening of the lining of your womb, thereby making it unfavorable for an egg to grow in it. Medroxyprogesterone Acetate Injection is a reliable and safe method for short-term contraception if used correctly. It does not interrupt with sex and is an effective contraception method for around 3 months (13 weeks) after which you need to visit the doctor for another injection.
The first-generation synthetic progestin ‘Medroxyprogesterone’ has been marketed for many decades in this injectable form. It is a preparation that provides contraception for a long term of 12 weeks with just one injection. Medroxyprogesterone Acetate shot is the most effective reversible contraceptive, with failure rates lower than those of the IUCD and the combined pill. Its injudicious and sometimes off-label injection, coupled with usage as a mass contraceptive for women in impoverished socio-economic settings, has led to its disrepute and a misconstrued focus on its side effects and risks rather than its benefits. It does have a few other excellent additional applications in the treatment of Endometriosis and breast cancer.
When used in this depot suspension form, Medroxyprogesterone Acetate shot has long-term effects progestin administration effects. Suppression of ovulation is the prominent and primary role of the Medroxyprogesterone Acetate birth control shot. MPA (Medroxyprogesterone Acetate) in the bloodstream suppresses LH and FSH hormones of the brain. This, in turn, results in the prevention of the successful maturation of follicles in the ovary, ultimately leading to no ovulation, cycle after cycle.
The womb lining or endometrium is also made soggy or decidualized and unfriendly to receive an impregnated egg if any. The mucus at the Cervix or mouth of the womb becomes viscous and impenetrable by sperms. Its Anti-Cancer role is explained by suppression of the central – peripheral or hypothalamic-pituitary – tissue axis of interaction. In other words, MPA totally suppresses natural or endogenous hormonal production such as that of estrogen, consequently protecting tumors from its proliferative effects.
Medroxyprogesterone Acetate birth control shot is commonly available as a 150mg/ml vial of 1ml in size. The active ingredient present in the Medroxyprogesterone Acetate shot is Medroxyprogesterone Acetate which is present in the vial as an aqueous suspension of a white powder. A disposable syringe bearing a wide bore needle is provided in the package. It was originally researched and marketed by Upjohn Pharmacia.
Administration And Dosing
Medroxyprogesterone Acetate contraceptive injection is meant for deep intramuscular injection ensuring that the complete suspension is withdrawn without any remaining in the vial. Prior agitation or vigorous shaking of the vial is valuable to thoroughly mix up the drug in the suspension facilitating easy withdrawal and maximum availability. It is preferably injected into the buttock, deltoid or arm is acceptable but it is not meant for subcutaneous use.
Medroxyprogesterone Acetate Injection Uses
Medroxyprogesterone Acetate provides long-term contraception. Besides this, it is also used in the treatment of Endometriosis and breast cancer.
- Contraception: The first or initial injection is given anytime during the first five days of menses. It can be used postpartum within 5 days if not breastfeeding or at 6 weeks postpartum (after excluding pregnancy) when exclusively breastfeeding.
The injection is repeated at precisely 90-day intervals and may be given a few days earlier but not later. It is not recommended to use it for more than 1 to 2 years because of the hazards of long-term adverse effects.
- Endometriosis: It is administered in smaller doses of 50 to 100mg given weekly to fortnightly respectively in a continuous manner for at least 6 months.
- Breast Cancer: It is not the primary treatment for breast cancer and is used as part of the milieu of hormone therapy for progestin receptive cases, with recurrence, in postmenopausal women. Doses of 500mg to 1gm are used daily for the first 28 days followed by a maintenance schedule of 500mg twice weekly. Treatment responses take time and any adverse changes or progression in cancer warrant immediate stoppage of Medroxyprogesterone Acetate.
- Endometrial / Renal Cancer: It is used in these cancers as an adjunctive or palliative therapy for advanced inoperable cases and for those with recurrence or metastasis. 500mg to 1gm are recommended initially and based on improvements the dose is reduced.
Medroxyprogesterone Acetate Effectiveness and Benefits
Contraceptive Advantages of Medroxyprogesterone Acetate Injection. The effectiveness and advantages of the Medroxyprogesterone Acetate Contraceptive Shot are given below:
- Medroxyprogesterone Acetate Shot is convenient since it involves just one injection every 90 days.
- Culturally acceptable in those parts of the world where the belief exists that, injections are superior to pills.
- Creation of a state of near-total amenorrhea.
- Absent periods for longer durations are advantageous in preventing Iron deficiency anemia.
- Sickling of red blood cells is reduced and is ideal as a contraceptive for women who suffer from sickle cell anemia or disease.
- Ideal contraceptive for nursing mothers as MPA does not affect the quantity or quality of breast milk or the infant’s health.
- Extremely effective and superior in preventing pregnancy when compared to contraceptive leaders such as the IUD or the combined pill.
- Attending complications of menstruation such as painful cramps or dysmenorrhea and heavy menstrual blood loss or menorrhagia is inherently avoided.
- It affords cancer protection against Endometrial (womb lining) malignancies.
Medroxyprogesterone Acetate Shot Side Effects
The possible side effects of Medroxyprogesterone Acetate Shot are given below:
- Irregular Bleeding: Unexpected irregular vaginal bleeding anytime during the use of Medroxyprogesterone Acetate is common after the first injection. Such may range from minor spotting to rarely excessive flow. It reduces with continuous injections of Depo Provera and with time there is a shift toward amenorrhea. Medical consult and therapy with low-dose estrogens such as Ethinyl estradiol or conjugated estrogens are necessary for women who are disturbed by it.
- Loss of Bone Mineral Density (BMD): Estrogen is vital to maintaining bone density. Complete suppression of hypothalamic-pituitary- Ovarian hormonal axis by Medroxyprogesterone Acetate leads to total suppression of estrogen production in the female body. Low estrogen further causes osteoporosis or brittle bones with loss of critical bone mass. This effect is noticed with prolonged use of 2 years or more in premenopausal women. It is substantially reversible. Use in younger women may predispose to weaker bones later on in life. Women with risk factors for osteoporosis such as low BMI from eating disorders, corticosteroid or anticonvulsants therapy, family history, metabolic bone disease, and alcohol/tobacco users, are at a greater risk for bone loss.
- Carcinogenic Effects: It is well known that DMPA confers protection against endometrial cancer for up to 8 years after discontinuation. Studies and clinical trials have conclusively demonstrated no risk of epithelial ovarian cancer, Liver cancer, or squamous cell cancer of the cervix with Medroxyprogesterone Acetate usage. There is no statistically significant increased risk in rates of breast cancer but there are reports of a slightly increased risk in younger women under 35 years of age within 4 years of earlier exposure. This risk rises in women under 25 years of age with more than 2 years of use.
- Weight Gain: There is a tendency to weight gain which is proportional to the duration of use. It was observed to have ranged through 2, 4, and 6 Kg for 1, 2, and 4 years of use respectively.
- Effects on Diabetes: In some users, Medroxyprogesterone Acetate for unclear reasons propels the blood sugar levels upwards by a reduction of glucose tolerance.
- Temporary Infertility: A delay in the resumption of fertility is noted on discontinuation of Medroxyprogesterone Acetate. The median time to pregnancy is 10 months after stopping use.
- Teratogenic Implications: Although a causal or directly attributable relationship is not demonstrated, there are reports of polysyndactyly (webbing of fingers or toes), chromosomal anomalies, hypospadias of the male fetus, virilization of the external genitalia of female fetuses, and low birth weight babies being born to women who inadvertently get pregnant while on Medroxyprogesterone Acetate.
The other side effects of Medroxyprogesterone Acetate contraceptive injection are as follows:
- Abdominal pain, constipation, diarrhea.
- Nausea, vomiting, disturbed liver functions, jaundice.
- White vaginal discharge, pelvic pain, vaginal infections, cervical erosions.
- Adrenergic effects – sweating, fine tremors, calf cramping
- Increased blood pressure, blood clotting tendency, heart attacks, brain strokes, palpitations.
- Increased White cell counts and platelets.
- Acne, Hirsutism, Alopecia, Rash.
- Bony, joint, and muscle pains or cramps, Breast pains.
Contraindications for Medroxyprogesterone Acetate Contraceptive Injection
Medroxyprogesterone Acetate Contraceptive Injection is contraindicated in patients with the following medical conditions:
- Undiagnosed or suspected pregnancy or unsure periods.
- Undiagnosed vaginal bleeding
- Suspected breast cancer or established breast cancer or high risk for breast cancer
- Hypersensitivity or allergy to Medroxyprogesterone acetate or other components in the formula.
- Currently suffering from or being treated for or having a past history of Blood clotting disorders or conditions that predispose to it, such as thromboembolism, Thrombophlebitis, brain or cerebral stroke, and severe uncontrolled high blood pressure.
- Severe Liver disease or deranged liver function tests.
Medroxyprogesterone Acetate Contraceptive Injection – Precautions
The precautions to be taken when undergoing treatment with a Medroxyprogesterone Acetate shot are as follows:
- Visual disturbances especially those arising out of the retinal vessels must be medically re-examined prior to use of Medroxyprogesterone Acetate
- The possibility of pregnancy and especially an ectopic pregnancy must be recognized in cases of vaginal bleeding with abdominal pain and a positive pregnancy test.
- Users with preexisting medical conditions such as epilepsy seizures, asthma, migraine, and cardiac and renal long-standing disorders have increased risks of fluid retention.
- A Pap smear is preferable in women at a higher risk for cervical cancer or even otherwise it is beneficial to get it done prior to Medroxyprogesterone Acetate use.
Medroxyprogesterone AcetateBirth Control Shot – Interactions
- Lab Tests: Medroxyprogesterone Acetate interferes in the Lab analysis of the following tests.
- Plasma or Urinary Steroids: Reduction in levels of Cortisol, estrogen, Progesterone, and Testosterone.
- Plasma or Urinary Gonadotropins: Reductions in levels of LH and FSH.
- Metyrapone Test And Glucose Tolerance Test: Values may be affected.
- Coagulation Tests: Values for factors II, VII, VIII, IX, and X are increased.
Buy Medroxyprogesterone Acetate Birth Control Shot 150 mg Online for Cheap
You can buy Medroxyprogesterone Acetate Contraceptive shot online from okdermo.com. Depo Provera is supplied in 1 ml vials containing a sterile aqueous suspension of 150 mg/ml. We also supply a needle with a disposable syringe.