Cuchel® Capsules

Trientine Hydrochloride USP 250mg

USD $680.00 (EUR €578.00)

Brands:MSN Labs

In the treatment of Wilson’s disease, there is an alternative option.

Wilson’s disease can be effectively treated with a low copper diet and chelating agents that bind copper to facilitate its excretion from the body. Cuchel® Capsules (generic Syprine) is a chelating agent indicated for the treatment of patients with Wilson’s disease who are intolerant of the first-line treatment, penicillamine.

Size: 100 Capsules Bottle
Brand name: Syprine, Tryprine, Clovique
Title Range Discount
Items: 2 - 4 5%
Items: 5 - 8 10%
Items: 9 + 15%
Category:

Description

What is Cuchel® Capsule with Trientine Hydrochloride USP 250mg?

Cuchel® Capsule is an effective therapy for Wilson’s disease. High-quality Syprine generic is a copper-chelating agent, with a polyamine-like structure chemically distinct from penicillamine. It lacks sulfhydryl groups and copper is chelated by forming a stable complex with the 4 constituent nitrogens in a planar ring. Cuchel® binds to copper in body tissues where it has built up and carries it into the bloodstream and then to the kidneys, which filter it into the urine.7

Wilson’s disease may be managed effectively with medications and diet. It is crucial that he or she does not stop taking his or her medication if he or she begins to feel better because Wilson’s disease is a chronic condition that must be managed throughout life. Cuchel® may be right for you if you have been diagnosed with Wilson’s disease; Cuchel® is not interchangeable with penicillamine and should be used only by patients who experience intolerable or life-threatening side effects from penicillamine. Tell your doctor about any allergic reactions you might have had while taking Cuchel®, including rashes or symptoms of asthma or bronchitis. All patients taking Cuchel® but especially women should be frequently tested for anemia. Female patients should inform their doctors if they become pregnant, plan to nurse, or plan to become pregnant.

Cuchel® is contraindicated in patients hypersensitive to Trientine Hydrochloride or any components of the formulation. Patients should be observed closely for signs of possible hypersensitivity. Patients receiving Cuchel® should remain under regular medical supervision throughout the period of drug administration. Patients (especially women) should be closely monitored for evidence of iron deficiency anemia.

Where to buy Syprine generic? Okdermo offers high-quality Syprine generic Cuchel® Capsules with the same active component – Trientine Hydrochloride USP 250mg.


What is Wilson’s disease?

Wilson’s disease is a rare inherited disorder that causes copper to accumulate in your liver, brain, and other vital organs. Most people with Wilson’s disease are diagnosed between the ages of 5 and 35, but it can affect younger and older people, as well.

Copper plays a key role in the development of healthy nerves, bones, collagen, and skin pigment melanin. Normally, copper is absorbed from your food, and excess is excreted through a substance produced in your liver (bile).

But in people with Wilson’s disease, copper isn’t eliminated properly and instead accumulates, possibly to a life-threatening level. When diagnosed early, Wilson’s disease is treatable, and many people with the disorder live normal lives.


What triggers Wilson’s disease?

What causes Wilson’s disease? Wilson disease is caused by an inherited change or abnormality (mutation) in the ATP7B gene. It is an autosomal recessive disorder. This means that both parents must pass on the same abnormal gene to the child.


Symptoms of Wilson’s disease

Wilson’s disease is present at birth, but signs and symptoms don’t appear until the copper builds up in the brain, liver, or another organ. Signs and symptoms vary depending on the parts of your body affected by the disease. They can include:

  • Fatigue, lack of appetite, or abdominal pain
  • A yellowing of the skin and the whites of the eye (jaundice)
  • Golden-brown eye discoloration (Kayser-Fleischer rings)
  • Fluid buildup in the legs or abdomen
  • Problems with speech, swallowing, or physical coordination
  • Uncontrolled movements or muscle stiffness

When to see a doctor: make an appointment with your doctor if you have signs and symptoms that worry you, especially if a family member has Wilson’s disease.


Indication of Syprine generic Trientine Hydrochloride USP 250mg

Cuchel® Capsule (trientine hydrochloride) is used to treat Wilson’s disease in patients who cannot take the medication known as penicillamine. Wilson’s disease is a condition where the body stores too much copper. Cuchel® Capsule is not recommended to treat cystinuria (a condition where a protein known as cystine is excreted into the urine), rheumatoid arthritis, or a disease affecting the bile ducts in the liver known as biliary cirrhosis.


Important safety information

  • Do not take Cuchel® Capsule if you are allergic to it or any parts of the formulation.
  • You should remain under regular medical supervision the entire time you are taking Cuchel® Capsules. Your doctor should regularly check to see if you have iron-deficiency anemia. This is particularly important for women.
  • Take Cuchel® Capsules on an empty stomach, at least one hour before a meal or two hours after a meal, and at least one hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and should not be opened or chewed. For the first month of treatment, take your temperature every night, and report any symptoms such as fever or skin rash to your doctor.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are nursing.
  • The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm,s and an immune disease affecting muscles known as myasthenia gravis.
  • Do not take mineral supplements because they may block the absorption of Cuchel® Capsules.

When determining the correct dosage for the patient, consider how they respond to Trientine Hydrochloride USP 250mg.

The doctor may advise you to take Trientine Hydrochloride USP 250mg 2, 3, or 4 times daily. Cuchel® Capsules should always be taken on an empty stomach, at least 1 hour before meals or 2 hours after meals, and at least 1 hour apart from any other drug, food, or milk. The capsules should be swallowed whole with water and not opened or chewed. If any medication comes into contact with the skin, the area should be washed with water right away to avoid the development of a rash.

Mineral supplements should not be taken with Cuchel® Capsules, as they can block absorption of Cuchel® Capsules into the bloodstream. A short course of iron supplements may be prescribed to patients with anemia, but these must be taken at least 2 hours apart from Cuchel® Capsules, as iron and Cuchel® Capsules can interfere with each other.

Please carefully follow these dosing guidelines because food, mineral supplements, and other medications can interfere with how Cuchel® Capsule is absorbed into the body.


Wilson’s Disease Support and Information

  1. Wilson Disease Association (WDA)
  2. American Liver Foundation
  3. National Organization for Rare Diseases (NORD)
  4. Patients Like Me
  5. Inspire

Composition

Each hard gelatin capsule contains Trientine Hydrochloride USD 250mg

Excipients Q.S. & Approved colors used in the capsule shell.

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