Combigan® Ophthalmic Solution

Timolol Maleate 5mg + Brimonidine Tartrate 2mg

USD $34.00 (EUR €28.22)


Combigan® Ophthalmic Solution (Brimonidine Tartrate and Timolol Maleate Ophthalmic solution) is an alpha-2 adrenergic agonist with a non-selective beta-adrenergic receptor blocking agent. Combigan® Ophthalmic Solution is a combination of two medicines: Timolol and Brimonidine. Timolol is a beta-blocker while Brimonidine is a sympathomimetic. They work by decreasing the production of aqueous humor (fluid in the eye), thereby lowering the increased eye pressure.

Combigan® Ophthalmic Solution is an eye drops medicine used for the treatment of pressure in the eyes (ocular hypertension) and glaucoma. It works by decreasing the pressure of fluid in the eye (aqueous humor), which helps in lowering the increased eye pressure.

📍 Product Information Brochure

Size: 5ml / 0.17fl.oz
Items:2 - 4 5%
Items:5 - 8 10%
Items:9 + 15%


What is Combigan® (Timolol Maleate 5mg + Brimonidine Tartrate 2mg)?

Combigan® (Brimonidine Tartrate/ Timolol Ophthalmic solution) 0.2%/0.5% is indicated for the reduction of elevated intraocular pressure in patient glaucoma or ocular hypertension who are insufficiently responsive to topical Beta-Blockers.

Combigan®  (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is approved for reducing elevated intraocular pressure (IOP) in patients with glaucoma who require additional or adjunctive IOP-lowering therapy. Combigan® lowers IOP slightly less than taking both brimonidine tartrate three times a day and timolol maleate two times a day.

Ocular hypertension is a condition where the pressure inside the eye is higher than normal eye pressure due to fluid build-up. Combigan Ophthalmic Solution increases the flow of fluid from inside the eye into the bloodstream thereby lowering the increased eye pressure. This prevents further damage or complications such as a change in vision or even loss of vision. You should only use Combigan Ophthalmic Solution in the affected eye and take it regularly as prescribed by your doctor.

What is glaucoma?

Glaucoma is a disease that damages the eye’s optic nerve, which can be caused by extra fluid that increases pressure in the eye. Open-angle glaucoma is the most common form of glaucoma. It develops gradually and often goes unnoticed at first. Regular eye exams are important to find early signs of damage to the optic nerve.

While there is no cure for glaucoma, studies show that lowering high eye pressure can help reduce the risk of glaucoma-related vision loss. That’s why treatment of high eye pressure is very important. Remember, high eye pressure can slowly, but permanently, damage your optic nerve before you notice any change in vision.

Your doctor can recommend an eye drop to help you manage your glaucoma or high eye pressure. One option is Combigan®. Twice-daily Combigan® is a treatment proven to lower eye pressure for glaucoma patients who require additional medication. Combigan® is approved to lower pressure in the eyes of people with primary open-angle glaucoma or ocular hypertension (both conditions involve high pressure in the eye) who require additional or adjunctive IOP-lowering therapy.

Remember to use Combigan® twice a day, every day

  • The recommended dose of Combigan® is 1 drop in the affected eye(s) twice a day, about 12 hours apart.
  • Combigan® may be used alone or with other eye drops to lower eye pressure for your glaucoma requiring additional IOP-lowering therapy.
  • If you use more than 1 type of topical eye drop, they should be applied at least 5 minutes apart.

How to use Combigan® (Timolol Maleate 5mg + Brimonidine Tartrate 2mg)?

  • Apply Combigan® eye drops exactly as your eye doctor prescribed. The recommended dose is 1 drop of Combigan® in the affected eye(s) twice a day, 12 hours apart. If you use more than 1 type of eye drop, just be sure to apply them at least 5 minutes apart.
  • If you have open-angle glaucoma or ocular hypertension, it is important to continue your Combigan® therapy. Don’t skip or stop treatment (unless you have spoken to your doctor). Remembering to use your eye drops is easier if you make it part of your daily routine.
  • If you wear contact lenses, remove them first, then wait 15 minutes after using Combigan® before you put them back into your eyes.

Side effects of Combigan®

In a year-long study, the most common adverse reactions occurring in approximately 5% to 15% of patients (n=385) included:

  • Allergic inflammation of the eye
  • Abnormally large lymph follicles in the mucous membrane lining the inner surface of the eyelid and the exposed surface of the eyeball (also called the conjunctiva)
  • Eye redness
  • Severe itching of the eyes
  • Burning and stinging of the eyes

Combigan® eye drops can be absorbed by your body. Contact your eye care professional right away if you experience any of the following potentially serious side effects:

  • Shortness of breath
  • Visual changes
  • Irregular heartbeat and/or slowing of your heart rate

Combigan® ophthalmic solution may cause fatigue and/or drowsiness. If you drive or perform hazardous work, such as operating machinery, make sure you feel appropriately alert. Ocular hypersensitivity reactions have been reported, with some reported to be associated with an increase in intraocular pressure. These risks are not the only risks associated with Combigan®. If you experience these or other side effects, you should immediately contact your eye doctor.


  • Timolol Maleate 5mg
  • Brimonidine Tartrate 2mg
  • Preservative: Benzalkonium Chloride IP/UNSF 0.05mg
  • Purified Water q.s.


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