Description
What is Cyclosporine 25mg/50mg/100mg ?
Cyclosporine is an immunosuppressive drug that was first used to help prevent rejection in organ transplant patients. In 1997, the Food and Drug Administration (FDA) approved Cyclosporine, for adults with severe psoriasis and otherwise normal immune systems. Cyclosporine suppresses the immune system and slows down the growth of certain immune cells.
Cyclosporine oral capsule is used to treat inflammation in rheumatoid arthritis and severe psoriasis. It’s also used to prevent the rejection of an organ transplant. Psorid® Cyclosporine belongs to a group of medicines known as immunosuppressive agents. It lowers your immune response and reduces the chance of your body attacking the transplanted organ. Organ rejection happens when your immune system treats the new organ as an invader and attacks it. This medicine suppresses the immune system and helps your body accept the new organ as if it were your own.
Cyclosporine works by weakening your immune system. White blood cells, part of your immune system, normally fight substances in your body that aren’t there naturally, such as a transplanted organ. Cyclosporine stops white blood cells from attacking a transplanted organ. In the case of RA or psoriasis, cyclosporine stops your immune system from mistakenly attacking your own body tissues.
Cyclosporine systemic is used in the treatment of Cogan’s Syndrome, Crohn’s Disease, Eczema, Evan’s Syndrome, Focal Segmental Glomerulosclerosis, Graft-versus-host disease, Idiopathic, Thrombocytopenic Purpura, Inflammatory Bowel Disease, Nephrotic Syndrome, Organ Transplant, Rejection Prophylaxis, Pemphigoid, Pemphigus, Psoriasis, Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis, Ulcerative Colitis, Active.
How Is Cyclosporine Used?
Cyclosporine is taken daily by mouth in capsule or liquid form. The liquid form must be diluted for use, preferably mixed at room temperature with orange or apple juice. Do not mix with grapefruit juice.
Cyclosporine must be taken on a consistent schedule. Cyclosporine is most often used for recalcitrant psoriasis that does not respond to other systemic treatments. Cyclosporine can provide rapid relief from symptoms. You may see some improvement in symptoms after two weeks of treatment, particularly with stronger doses. However, it may take from three to four months to reach optimal control.
Extended use of cyclosporine by transplant patients is well-established. However, long-term use as a treatment for psoriasis is more limited. The FDA recommends cyclosporine not be used for longer than one year. However, there are no specific guidelines for how long you should stay off cyclosporine before resuming treatment. Some doctors may prescribe the drug for more than one year.
Cyclosporine can be used with the topical drugs Dovonex – Calcipotriene is a form of vitamin D and Vectical – Calcitriol ointment. When using these topicals, lower doses of cyclosporine may be given, lessening the risk of side effects.
Warning For Psoriasis Patients:
Psoriasis patients previously treated with PUVA and to a lesser extent, methotrexate or other immunosuppressive agents, UVB, coal tar, or radiation therapy, are at an increased risk of developing skin malignancies when taking Ciclosporine. Ciclosporine in recommended dosages, can cause systemic hypertension and nephrotoxicity. The risk increases with increasing the dose and duration of cyclosporine therapy. Renal dysfunction, including structural kidney damage, is a potential consequence of cyclosporine, and therefore, renal function must be monitored during therapy.
Side effects of Cyclosporine
The more common side effects that occur with cyclosporine include high blood pressure, low magnesium levels in your body, blood clots in your kidneys, stomach pain, hair growth in certain areas, acne, tremors, headache, increased size of your gums. If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor.
Serious side effects. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following. Liver damage. Symptoms may include blood in urine, dark urine, pale stools, yellowing of your skin, or the whites of your eyes, pain in your upper abdomen.
How to use Psorid® Capsules Cyclosporine
Take this medication by mouth as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose.
The dosage is based on your weight, medical condition, lab tests, and response to treatment.
Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Dosage for psoriasis:
- Oral capsule strengths: 25 mg, 50 mg, and 100 mg
- Adult dosage (ages 18 years and older) Dosage is based on weight. Typical starting dosage: 2.5 mg/kg per day, divided into two doses (1.25 mg/kg per dose). Maximum dosage: 4 mg/kg per day.
- Note: If you don’t have good results after 6 weeks at the maximum tolerated dose, your doctor will have you stop taking cyclosporine.
Marrie O.L. –
I am taking 100 mg a day for about two weeks and it is doing a good job. Eczema on my hands had destroyed my personal and social life. Thank my dermatologist for prescribing me a cyclosporin-based med that treated my condition to normal and okdermo for providing such a lovely service with prompt delivery to the UK.
Mei-Ling Zhang –
This was prescribed for my ulcerative colitis, and it felt like a miracle. The abdominal pain diminished significantly. While I did experience some minor tremors, they were tolerable and got better over time.
Isabella Dupont –
As an immunosuppressant, it can be a bit intimidating, but I haven’t experienced any major issues. It significantly reduced my symptoms of Cogan’s syndrome. Monitoring my lab results regularly has been essential.
Hans Müller –
Psoriasis was ruining my confidence, and this drug turned things around for me. In just a couple of weeks, the scaling reduced significantly. I do have to be careful about any signs of blood pressure changes.
Sofia Rossi –
This helped prevent my organ transplant from being rejected, and I couldn’t be more grateful. It does require discipline to take it at the same time daily, but overall, it’s been a lifesaver. I haven’t had any severe side effects yet.
Daisuke Tanaka –
I’ve been using it for rheumatoid arthritis, and it’s made a significant difference in managing my inflammation. Remember to keep an eye on your blood pressure, though. It’s crucial to monitor any changes with your doctor.
Rina Patel –
Managing my rheumatoid arthritis has been so much easier since starting this medication. I noticed a bit of hair growth in unusual places, which was odd but not a dealbreaker considering the relief I felt. Discuss any side effects with your doctor.
Sven L. Nilsen –
Using this for inflammatory bowel disease, it’s been a game-changer. Took a little while to dial in the correct dosage, but once settled, symptoms were minimal. It’s essential to have regular check-ins with your healthcare provider.
Thuli M. Ndlovu –
Managing Evans Syndrome with this medicine, and it’s been incredibly effective. The immune system suppression is concerning but necessary. Regular doctor visits to assess the effectiveness keep everything in check.
Abdullah Al-Mansoori –
The medication has been effective for my severe psoriasis, but grapefruit is a no-go. Accidentally drank the juice once and felt unwell. Learned my lesson, and I’ve had no issues since avoiding it.
Emily O’Connor –
After a kidney transplant, this helped me return to a normal life. The consistency in taking it daily is crucial for effectiveness. Honestly, the peace of mind it provides outweighs any minor side effects.
Arjun Mehta –
My Crohn’s disease was out of control until this medication. Although my blood pressure went up slightly, the reduction in flare-ups made it worth adjusting my diet and lifestyle to manage it.
Zuri Adeyemi –
While this medicine has helped greatly with my eczema, I have noticed some mild stomach discomfort. It’s nothing compared to the flare-ups I experienced before starting this treatment. Consistently taking it with food seems to help reduce any stomach issues.
Eleni Papadopoulos –
I’ve experienced a remarkable reduction in my pemphigus symptoms since starting this. It does require careful attention to any changes in mood or body due to potential side effects. However, the relief it provides is worth the diligence.
Seung-Min Choi –
Taking it for psoriatic arthritis, it reduced the inflammation significantly. Can’t stress enough the importance of regular blood tests to monitor kidney function, though. The benefits have far exceeded the downsides in my experience.
Amina Khalil –
I’ve been on this medication for severe psoriasis, and within a month, I noticed a significant improvement in my skin condition. It feels amazing not to have constant itching and redness. I did experience a few headaches, but they were manageable.
Mikhail Petrov –
After starting this for my eczema, the improvement in my skin was palpable. Initially faced some stomach issues, but adjusting my diet helped. It’s been a blessing and has changed my daily comfort level.
Nia P. Johnson –
My psoriasis improved quicker than expected. I had some concerns about long-term use, but short-term, it’s been fantastic. Just be cautious about sun exposure as I’ve noticed increased sensitivity.
George Ivanov –
Noticed my gums were slightly enlarged after starting this for my immune disorder, but the improvement was undeniable. It’s certainly a worthwhile trade-off for the benefits, but dental check-ups are now more frequent.
Lucas Fernández –
I was anxious about side effects, but the potential benefits made it worth it for my Crohn’s disease. It took a few weeks, but my symptoms drastically reduced. Just make sure to stay hydrated as it can be a bit hard on the kidneys.
Yasmin D. Oliveira –
The medication has kept my rheumatoid arthritis at bay. Some expected side effects like mild headaches have come and gone. Ensure to follow the schedule and dosage prescribed by your doctor for optimal results.