Aziderm Plus® Cream

Description

Aziderm Plus Cream – 15% Azelaic Acid + 70% Glycolic Acid

Dual-Mechanism Dermatological Therapy for Acne, PIH, and Textural Irregularities

Aziderm Plus Cream is a professionally formulated, high-potency topical treatment that synergistically combines 15% Azelaic Acid and 70% Glycolic Acid, two scientifically validated actives used in dermatology for the management of acne vulgaris, post-inflammatory hyperpigmentation (PIH), melasma, and photodamage-related skin texture abnormalities. This formulation is designed for patients requiring intensive intervention within a structured skincare protocol supervised by dermatologists or clinical aestheticians.

Mechanism of Action

• Azelaic Acid (15%) is a naturally occurring dicarboxylic acid with multiple pharmacologically relevant effects on the skin. It exhibits antimicrobial activity against Cutibacterium acnes and Staphylococcus epidermidis, two key contributors to inflammatory acne. Additionally, Azelaic Acid functions as a competitive inhibitor of mitochondrial oxidoreductase enzymes in hyperactive melanocytes, thereby reducing abnormal melanin production without causing cytotoxicity or damaging surrounding skin. Its comedolytic and anti-keratinizing properties also assist in normalizing follicular epithelium differentiation.
• Glycolic Acid (70%), the smallest and most bioavailable alpha-hydroxy acid (AHA), is employed in a controlled-release vehicle in this formulation to deliver targeted chemical exfoliation. At this concentration, Glycolic Acid induces epidermolysis, facilitating the desquamation of corneocytes, improving epidermal turnover, and stimulating dermal fibroblasts. Clinically, this results in smoother skin texture, reduction in superficial scars, and improved absorption of adjunctive topical agents. Glycolic Acid also disrupts corneocyte cohesion at the stratum corneum, thereby enhancing the penetration of Azelaic Acid and potentiating its bioactivity.

Clinical Indications

Aziderm Plus Cream is indicated for patients presenting with:

• Inflammatory and non-inflammatory acne lesions, including papules, pustules, and comedones

• Post-inflammatory hyperpigmentation (PIH) and melasma, particularly in skin types III–V where pigmentary dysregulation is prevalent

• Keratinization disorders such as seborrheic skin or retention hyperkeratosis

• Superficial acne scars and uneven skin tone/texture secondary to chronic breakouts or environmental exposure

Scientific Rationale and Comparative Advantage

While monotherapy with either Azelaic Acid or Glycolic Acid has established dermatological merit, the combination in Aziderm Plus Cream introduces a complementary mechanism of action: Azelaic Acid downregulates tyrosinase and reduces reactive oxygen species in the skin, while Glycolic Acid expedites epidermal turnover and enhances transdermal delivery. Together, they form a high-efficacy system for correcting both active lesions and residual dyschromia.

Studies have shown that Azelaic Acid 15% maintains comparable efficacy to 4% Hydroquinone for melasma, with fewer adverse events. When used adjunctively with a chemical peeling agent like Glycolic Acid, there is enhanced pigment dispersion, reduced epidermal thickening, and improved patient-reported outcomes on tone uniformity and skin clarity.

Formulation Considerations and Usage Guidelines

Due to the strength of the actives, Aziderm Plus Cream is recommended for professional application or under strict dermatological guidance. It may be used:

• As part of a bi-weekly or monthly chemical peel regimen

• In spot treatment protocols for stubborn pigmentation clusters or nodulocystic lesions

• In short-contact therapy (SCT) format for sensitive skin types or those undergoing skin barrier repair

Patch testing is advised prior to full-face application. Post-application, patients should use broad-spectrum sunscreen (SPF 30+) and barrier-supportive emollients to mitigate transient irritation or barrier disruption.

Contraindications and Precautions

This product should not be used in individuals with:

• Known hypersensitivity to alpha-hydroxy acids or Azelaic Acid

• Active eczema, rosacea flare-ups, or open wounds

• Recent use of isotretinoin (within past 6 months) unless cleared by a physician

Use during pregnancy should be evaluated on a case-by-case basis, although Azelaic Acid is categorized as FDA Pregnancy Category B.

Conclusion

Aziderm Plus Cream represents a clinically optimized, high-performance dermatological intervention that targets both the causal factors and residual manifestations of acne and pigmentation disorders. Its dual-active mechanism provides a science-backed solution for patients seeking rapid and sustainable improvements in skin clarity, tone, and texture—making it a valuable addition to any professional skincare protocol.