Description
What is Apixaban Used For?
Apixaban is a direct oral anticoagulant (DOAC) approved for the prevention and treatment of thromboembolic disorders. It is primarily prescribed to:
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Prevent stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF)
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Treat deep vein thrombosis (DVT) and pulmonary embolism (PE)
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Prevent recurrence of DVT and PE
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Prevent DVT following hip or knee replacement surgery
Off-label, Apixaban is occasionally used in cases such as cancer-associated thrombosis and mechanical heart valve thromboprophylaxis, though data in these areas are still being evaluated.
Brand names include: Eliquis (US, Canada, EU, UK, AU), Eliquis Apixaban (varies by region and regulatory status).
Eliquis Mechanism of Action
Apixaban selectively inhibits Factor Xa, a critical enzyme in the coagulation cascade responsible for converting prothrombin to thrombin. By inhibiting Factor Xa, Apixaban reduces thrombin generation, fibrin formation, and thrombus development, resulting in effective anticoagulation without requiring antithrombin III mediation. Unlike warfarin, Apixaban does not require routine INR monitoring and has fewer food-drug interactions.
Clinical Efficacy and Safety
Large-scale clinical trials such as ARISTOTLE and AMPLIFY have established the efficacy of Apixaban in reducing the risk of stroke and systemic embolism in atrial fibrillation patients and treating VTE with fewer bleeding complications compared to warfarin and enoxaparin. Apixaban demonstrates a favorable risk-benefit profile, especially in elderly populations and those with renal impairment.
Apixaban Dosage and Administration
Apixaban is available in two strengths: 2.5 mg and 5 mg tablets. The standard dosage is 5 mg taken orally twice daily. For certain populations, such as patients with at least two of the following: age ≥80 years, weight ≤60 kg, or serum creatinine ≥1.5 mg/dL, a reduced dosage of 2.5 mg twice daily is recommended.
Tablets can be taken with or without food. In case of missed doses, patients are advised to take the dose as soon as possible on the same day.
Source: FDA Prescribing Information
Apixaban Price and Availability
The cost of Eliquis without insurance may be high in certain markets, making it one of the more expensive DOACs. Patients looking to buy Eliquis online or explore cheap Eliquis options may consider verified pharmacy discount programs or manufacturer’s Eliquis coupon offerings. For affordability, many patients use an Eliquis discount card or search for apixaban coupon codes.
Patients frequently ask: Why is Eliquis so expensive? The answer lies in its patent protection, research and development costs, and market exclusivity.
Eliquis Generic Release Date and Price
Although Apixaban (Eliquis) received FDA approval in 2012, its generic availability in the United States has been delayed due to patent litigation. The Eliquis generic release date is currently anticipated no earlier than 2028, as per current court rulings.
In international markets, Eliquis generic price trends may vary. Some countries may have already approved biosimilar versions of Apixaban under different brand names or licensing agreements.
Alternatives to Apixaban
While Apixaban is widely recommended, alternatives include other DOACs such as:
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Rivaroxaban (Xarelto)
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Dabigatran (Pradaxa)
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Edoxaban (Savaysa)
In some patients, especially those with mechanical heart valves or severe renal impairment, warfarin remains the preferred anticoagulant. Patients exploring an alternative to Apixaban should consult a healthcare professional to determine the most appropriate choice based on clinical context.
Source: American Heart Association
Apixaban for Special Populations
Apixaban is considered safe and effective in the elderly and in patients with moderate renal impairment. However, in end-stage renal disease or those on dialysis, caution is advised. Apixaban is generally not recommended during pregnancy or breastfeeding due to limited safety data.
Buy Eliquis Online Safely
Patients can buy Eliquis online through licensed pharmacies. Always ensure that the online pharmacy is certified and provides FDA-approved or Health Canada-approved medications. Be wary of heavily discounted or unverified sellers offering cheap Eliquis, which may be counterfeit.
Price Eliquis 5 mg vs Eliquis 2.5 mg Price
The price for Eliquis 5 mg and Eliquis 2.5 mg price may differ depending on quantity, supplier, and region. Larger quantities typically offer better per-unit pricing. Using coupons or discount cards can substantially reduce both Apixaban price tiers.
Frequently Asked Questions (FAQ)
What is Apixaban used for?
Apixaban is used to prevent and treat blood clots, including stroke prevention in atrial fibrillation, treatment and prevention of DVT and PE, and clot prevention after orthopedic surgery.
How does Apixaban work?
Apixaban works by inhibiting Factor Xa, which plays a crucial role in the formation of blood clots. This mechanism reduces clot formation without needing frequent blood testing.
Is there a generic version of Eliquis?
No, a generic version of Eliquis is not expected to be available in the U.S. until at least 2028 due to patent restrictions.
Why is Eliquis so expensive?
The high cost is due to factors like patent exclusivity, research investments, and its high demand as a safe alternative to warfarin.
What are the alternatives to Apixaban?
Alternatives include rivaroxaban, dabigatran, and edoxaban. Warfarin is also used in specific clinical scenarios.
Can I buy Apixaban online?
Yes, you can buy Apixaban or Eliquis online from verified and licensed pharmacies. Always check for legitimate sources.
How can I lower my Apixaban cost?
You can use an Eliquis coupon, an Eliquis discount card, or seek an Apixaban coupon through pharmacy discount programs.
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