WHAT IS AM-EXIDIL MINOXIDIL 5%, AMINEXIL 1.5% SPRAY
Am-Exidil Spray-On Topical Solution made by reputable Sun Pharma. Am-Exidil Solution comes in spray form and is used for the treatment of hair loss. Amexidil Topical Solution consists of Minoxidil 5% w/v and Aminexil (Kopexil) 1.5% w/v.
Minoxidil 5% – increases the size of the hair follicles and opens up potassium channels which allow more blood and nutrients to the hair follicle. Minoxidil 5% helps to reactivate the hair growth cycle, and after 2-4 months of use, most patients notice thicker hair, intensive and consistent growth, follicles restoration/repair. Minoxidil is a relatively easy, safe way to fight the loss of your hair.
Kopexil 1.5% (diaminopyrimidine oxide, trade name – Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure. The side effect was increased body hair. Aminexil is used in the treatment of hair loss and male pattern baldness. Aminexil works by increasing the blood flow to the hair follicles, thus increasing hair follicle size, and prolonging the growth phase of these follicles, which then promotes hair growth and halting further loss of hair. Both compounds have been used for therapy of alopecia.
Alopecia – is a hair loss condition, also known as baldness, refers to a loss of hair from part of the head or body. Typically at least the head is involved. The severity of hair loss can vary from a small area to the entire body. Typically inflammation or scarring is not present. Hair loss in some people causes psychological distress. Common types include male-pattern hair loss, female-pattern hair loss, alopecia areata, and a thinning of hair known as telogen effluvium. The cause of male-pattern hair loss is a combination of genetics and male hormones, the cause of female pattern hair loss is unclear, the cause of alopecia areata is autoimmune, and the cause of telogen effluvium is typically a physically or psychologically stressful event. Telogen effluvium is very common following pregnancy.
WHAT IS MINOXIDIL 5%
Minoxidil 5% – more commonly known by the brand name Rogaine – is the only topically-applied hair loss treatment approved by the FDA. Various trials have shown it to be effective at regrowing hair. However, no one actually knows how it works and doubts have been raised about how effective it is in the long term.
Minoxidil is a topical hair restoration agent. First approved in 1988 to treat androgenetic alopecia (male pattern hair loss), the drug was originally prescribed in oral form to treat high blood pressure. After noticing unexpected hair growth in patients, the drug was trialled to treat hair loss. When these trials proved successful, Rogaine was approved by the US FDA for this use.
Since then, the patent for Rogaine has expired and manufacturers are now free to produce generic formulations of minoxidil. Typically, these will be 5% concentration, although 2% and 10% solutions are also available. Available in liquid, foam, and spray forms, minoxidil is applied to the scalp twice daily – once in the morning and once at night. For maximum effect, it should be left on the scalp for at least four hours before being washed out. Like most hair loss treatments, minoxidil will only work for as long as you use it. As soon as you stop taking it, hair loss will return to how it was before.
Despite being FDA approved to treat hair loss, nobody is entirely sure how minoxidil actually works. Currently, science says that the hormone dihydrotestosterone (DHT) binds to hair follicles and causes them to shrink. This is why DHT-reducing drugs such as finasteride are effective at slowing and reversing hair loss. But minoxidil has no effect on DHT levels. As minoxidil is a vasodilator, some claim that its hair-regrowing effects are due to increased blood flow. However, the link between hair loss and blood flow is disputed.
Even after the initial trials of minoxidil, the FDA concluded that the product will not work for everyone. And this more recent trial gives an idea of its effectiveness: “Clinical response to 5% topical minoxidil for the treatment of androgenetic alopecia (AGA) is typically observed after 2-5 months. Approximately 50% of patients will regrow hair.“
This is still a somewhat impressive statistic. It is far more difficult to regrow hair than it is to maintain. Of course, there are different strengths, dosages, and methods of administration with minoxidil. Broadly, though, it is dose-dependent, with higher concentrations producing better results than lower concentrations. This study found: “In men with AGA, 5% topical minoxidil was clearly superior to 2% topical minoxidil and placebo in increasing hair regrowth, and the magnitude of its effect was marked (55% more hair regrowth than 2% topical minoxidil at week 48). Men who used 5% topical minoxidil also had an earlier response to treatment than those who used 2% topical minoxidil.”
Despite the ability of minoxidil to regrow hair, it is not likely to be effective at maintaining it as it does not tackle the root cause: DHT. As a standalone treatment minoxidil will not prevent DHT from binding to hair follicles and shrinking them. However it works, it doesn’t appear to slow the cumulative damage caused by hormones. But when used in conjunction with other medications – such as finasteride or dutasteride – it can produce some seriously impressive results. In some cases, patients may see significant and lasting regrowth.
WHO MAY NEED AM-EXIDIL SPRAY & HOW IT WORKS
Minoxidil which is the main ingredient of Am-Exidil Spray applied topically to the scalp works if your hair loss is a result of female pattern baldness and not some other condition. Normally, hair grows about half of an inch each month. Each hair grows for up to six years, then it stops growing, rests for a while, and eventually falls out and is replaced by a new hair that grows for six years. If your hair is growing normally, about 85 percent of it is growing at any given time and 15 percent of it is resting.
But if you have female pattern baldness, your hair follicles get smaller and smaller over time. The smaller they are, the shorter the amount of time your hair grows. Eventually, when strands of hair fall out, they’re not replaced with normal new hair, but instead by thinner, finer strands of hair. Doctors think that, among other possible causes, ageing, genetics, and a change in the level of male hormones, or androgens, after menopause may be part of what brings on female pattern baldness. (That’s why female pattern baldness is also called androgenetic alopecia).
Minoxidil is the only drug which is FDA-approved to treat female pattern baldness. It works by prolonging the growth phase of the hair follicles. It’s recommended that women use minoxidil 2%, while men can use the 5% and 10% formula.
Minoxidil Benefits: In most women, minoxidil slows down or stops hair loss. And in up to a quarter of the women who take it, minoxidil can actually encourage new hair to grow. It works best when you use it as soon as you notice that you’re losing hair. Everyone encouraged to see a primary care doctor or a dermatologist before beginning treatment, because there could be a medical problem that’s causing the hair loss, such as thyroid dysfunction or nutritional abnormalities.
Minoxidil Disadvantages: There also are some disadvantages to taking minoxidil as a hair loss treatment.
- Inconvenient for someone – you have to apply it to the scalp two times a day.
- It can cause unwanted hair growth – some women may experience facial hair growth when they use minoxidil, especially stronger concentration one 5%. That can happen if the medication trickles down onto your face or simply as a side effect when you apply it only to your scalp. The risk is lower for women who use the 2 percent concentration of the drug, as opposed to the 5 and 10 percent concentration that’s designed for men.
- It can cause more hair loss at first – you may notice an increase in hair loss during the first two to four weeks of using minoxidil. That happens because some of the old hairs are being pushed out by new ones.
- It can take months to see results – you have to use it for at least 3 months — and possibly half a year— before you see results. Even then, only about three in five women will have moderate hair regrowth, with a larger percentage noticing only that their hair loss seems to slow down or stop.
- It can irritate your skin – you may experience some irritation, flaking, and redness.
Unsurprisingly, minoxidil is not a miracle hair loss cure. For some users, it can lead to dramatically improved hair, for others, it has no effect. Like all drugs, it has its advantages and disadvantages:
- Regrows hair for many (~50%) of users
- Different mechanism of action means it can be used in conjunction with other treatments for better results
- Minimal side effects
- Low cost
- Doesn’t tackle the underlying cause of hair loss (DHT)
- Some formulas can be messy to apply
- Doesn’t work for everyone
If you do decide to try it out, my advice would be don’t rely on minoxidil alone. Though you may see an initial improvement with minoxidil only, the hair loss process will still continue if the underlying hormonal causes are not addressed. For this reason, minoxidil is best used in conjunction with other proven hair loss treatments like finasteride.
SIDE EFFECTS FROM USING AM-EXIDIL SPRAY
Patients who take Am-Exidil Minoxidil 5%, Aminexil 1.5% Spray Solution may suffer from such side effects: a headache, redness, dryness of the skin, flaking or scaling of the scalp, irritation, allergic reaction, skin rash, chest pain, edema, dermatitis, abnormal hair growth on a women face and body, dizziness, tiredness.