Allegra® Fexofenadine Tablets

Description

What is Fexofenadine Hydrochloride?

Fexofenadine hydrochloride is a selective H1-receptor antagonist classified as a second-generation antihistamine. It is primarily indicated for the symptomatic relief of allergic conditions, including seasonal allergic rhinitis and chronic idiopathic urticaria (CIU). Unlike first-generation antihistamines, fexofenadine does not easily cross the blood-brain barrier, resulting in minimal sedation or cognitive impairment, making it a preferred choice among healthcare providers.

Fexofenadine Brand Names by Market

USA: Allegra
UK: Allevia
Canada: Apo-Fexofenadine, Teva-Fexofenadine
EU: Telfast
Australia: Fexotabs, Telfast

Fexofenadine Over the Counter Availability

Fexofenadine is now available over the counter in many countries, including the USA, UK, and Australia, following a proven record of safety. In the UK, patients often ask, “Can I buy fexofenadine over the counter in UK?” — the answer is yes, under the brand Allevia. Its accessibility makes it convenient to buy fexofenadine 180mg or buy fexofenadine 120mg without a prescription. You can now confidently buy fexofenadine online at OKDERMO for efficient delivery and genuine medication.

Indications and Uses

On-Label Uses:

• Seasonal Allergic Rhinitis (Hay Fever): Fexofenadine 120mg is indicated to relieve sneezing, nasal congestion, runny nose, and itchy/watery eyes caused by pollen, mold, or pet dander.

• Chronic Idiopathic Urticaria (CIU): Fexofenadine 180mg is commonly used to treat persistent hives and itching without an identifiable cause.

Off-Label Uses (Clinically Reported):

• Atopic Dermatitis Adjunct: Occasionally used in cases of moderate eczema to control pruritus PubMed.

• Allergic Conjunctivitis: While not an official indication, fexofenadine is sometimes used adjunctively to reduce eye itching and inflammation.

How Fexofenadine Works

Fexofenadine blocks the histamine H1-receptors located on the surface of cells in the respiratory tract, blood vessels, and gastrointestinal tract. Histamine, released during allergic reactions, causes inflammation and classic allergy symptoms. By inhibiting this mechanism, fexofenadine provides rapid relief without causing drowsiness, unlike older antihistamines like diphenhydramine.

Its pharmacokinetics include:

• Peak plasma concentration: ~2.6 hours after oral administration.

• Half-life: Approximately 14 hours.

• Metabolism: Minimal hepatic metabolism, reducing risk of drug-drug interactions.

• Excretion: Primarily fecal (80%), some renal elimination (10%).

Source: FDA Label – Drugs.com

Dosage and Administration

• Fexofenadine 120mg: Recommended once daily for seasonal allergic rhinitis in adults and children over 12 years.

• Fexofenadine 180mg: Once daily for chronic idiopathic urticaria in adults and children over 12 years.

It should be taken with water, not fruit juice, as juice may reduce bioavailability due to inhibition of intestinal transporters NIH.

Safety and Side Effects

Fexofenadine is generally well-tolerated. Common adverse effects include:

• Headache

• Nausea

• Drowsiness (rare, <1%)

• Dizziness

Serious adverse reactions are rare but may include hypersensitivity reactions and arrhythmia in predisposed patients.

Reference: Mayo Clinic

Contraindications and Interactions

• Contraindications: Known hypersensitivity to fexofenadine or any inactive ingredients.

• Drug Interactions: Avoid concurrent use with antacids containing aluminum or magnesium, as they reduce drug absorption. Avoid grapefruit or apple juice.

Special Populations

• Elderly: No dosage adjustment required, but renal function should be considered.

• Renal Impairment: Caution advised; fexofenadine exposure increases in severe renal impairment.

• Pregnancy Category C: Use only if clearly needed. Not extensively studied in pregnant women.

• Breastfeeding: Fexofenadine is excreted in breast milk; caution is recommended.

Fexofenadine Hydrochloride 180 mg Uses and Novel Insights

Recent studies have shown that fexofenadine hydrochloride 180 mg may have anti-inflammatory effects beyond simple histamine antagonism. These effects include inhibition of eosinophil migration and cytokine release, which may support its use in more complex allergic conditions.

Additionally, research suggests potential benefits in cold-induced urticaria and mast cell activation syndrome (MCAS), though more studies are needed to confirm these off-label applications.

Reference: NIH Clinical Trials

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FAQ

Is Fexofenadine over the counter?
Yes, in many countries like the US, UK, and Australia, fexofenadine is available OTC.

Can I buy Fexofenadine over the counter in UK?
Yes, under the brand name Allevia, it is sold in most UK pharmacies without a prescription.

What is the difference between Fexofenadine 120mg and 180mg?
The 120mg dose is mainly for hay fever, while the 180mg dose is used for chronic urticaria.

How long does it take for Fexofenadine to work?
Onset of action is usually within 1 hour, with peak effects at 2–3 hours.

Can I take Fexofenadine daily?
Yes, both 120mg and 180mg tablets are designed for once-daily use.