Name: Aklief® Trifarotene Cream
Brand: Galderma
Availability: InStock

Trifarotene 0.005%

USD $93.00

Aklief® Trifarotene Cream helps treat acne (commonly called pimples) by reducing inflammation and targeting other important factors that cause acne.

It may take a few weeks to have a noticeable effect so keep using it even if it appears not working. Sometimes acne may get worse before it gets better, however, with proper use, your skin will get clearer.

The earlier you start using it, the less likely you are to get scars. This medicine will help improve your mood and uplift your confidence as your skin becomes acne-free.

Size: 30g / 1.06oz

Title	Range	Discount
Items:	2 - 4	5% USD $88.35
Items:	5 - 8	10% USD $83.70
Items:	9 +	15% USD $79.05

Description

Trifarotene cream is used to treat acne. This medicine works to help clear acne by keeping the skin pores (tiny openings on the skin) clean. Trifarotene, sold under the brand name Aklief, is a medication for the topical treatment of acne vulgaris. It is a retinoid; specifically, a fourth-generation selective retinoic acid receptor (RAR)-γ agonist.

Aklief® Trifarotene Cream is an innovative topical single-agent retinoid cream proven safe and effective for acne on your face, shoulders, chest, and back. Aklief® Trifarotene Cream contains the retinoid molecule trifarotene, which helps the skin replace its old skin cells at a faster speed, exfoliating away the old cells in the process and helping prevent new acne from forming. It may also reduce inflammatory acne often experienced with pimples.

Trifarotene Cream: Comprehensive Product Overview

Trifarotene Cream, marketed under the brand name Aklief, is a topical retinoid specifically formulated for the treatment of acne vulgaris. As a fourth-generation retinoid, trifarotene selectively targets the retinoic acid receptor gamma (RAR-γ), the most prevalent retinoic acid receptor in the skin. This selectivity enhances its efficacy in promoting cell turnover and reducing inflammation associated with acne.

On-Label Uses

Acne Vulgaris

Facial Acne: Trifarotene Cream is FDA-approved for treating acne on the face, effectively reducing both inflammatory lesions (such as papules and pustules) and non-inflammatory lesions (such as blackheads and whiteheads).
Truncal Acne: Uniquely, trifarotene has demonstrated efficacy in treating acne on the chest, shoulders, and back, areas often overlooked in acne treatments. Clinical studies have shown significant improvement in truncal acne with trifarotene application.

Off-Label Uses

While trifarotene is primarily indicated for acne vulgaris, ongoing research suggests potential off-label applications:

Congenital Ichthyosis: Trifarotene has been granted orphan drug designation for the treatment of congenital ichthyosis, a group of disorders characterized by dry, scaly skin.
Hyperpigmentation: Some studies indicate that trifarotene may possess anti-pigmenting properties, potentially aiding in the reduction of dark spots and post-inflammatory hyperpigmentation.

Benefits

Selective Receptor Targeting: Trifarotene’s specificity for RAR-γ enhances its therapeutic effects on acne lesions while potentially minimizing systemic side effects.
Comprehensive Coverage: Effective for both facial and truncal acne, providing a holistic treatment approach.
Rapid Onset of Action: Patients may observe visible improvements in as little as two weeks.

Precautions and Warnings

Skin Irritation: Common adverse reactions include redness, scaling, dryness, and stinging/burning sensations, particularly during the initial weeks of treatment. Utilizing a moisturizer can help mitigate these effects.
Sun Sensitivity: Trifarotene may increase skin sensitivity to sunlight. Patients are advised to minimize sun exposure and use sunscreen and protective clothing when outdoors.
Application Guidelines: Avoid applying the cream to cuts, abrasions, eczematous, or sunburned skin. The use of waxing for hair removal on treated areas is not recommended.
Pregnancy and Lactation: The safety of trifarotene during pregnancy and breastfeeding has not been established. Consult a healthcare provider before use if you are pregnant, planning to become pregnant, or breastfeeding.

Frequently Asked Questions (FAQ)

1. How should I apply Trifarotene Cream?

Apply a thin layer once daily in the evening to clean, dry skin on the affected areas. For the face, one pump actuation is typically sufficient; for the upper trunk, two actuations may be needed. Avoid contact with eyes, lips, and mucous membranes.

2. When can I expect to see results?

Improvements may be noticeable within two weeks; however, consistent use over several weeks is recommended to achieve optimal results.

3. Can I use other skincare products with Trifarotene Cream?

Yes, but avoid products that may cause additional irritation, such as those containing alcohol, astringents, or exfoliants. Incorporating a moisturizer is advisable to alleviate potential dryness.

4. What should I do if I experience severe skin irritation?

If severe irritation occurs, reduce the frequency of application or temporarily discontinue use. Consult your healthcare provider for personalized advice.

5. Is Trifarotene Cream safe for children?

Trifarotene Cream is approved for use in patients aged nine years and older.

6. Can I undergo hair removal treatments while using Trifarotene Cream?

Avoid waxing on treated areas, as it may cause skin irritation. Consider alternative hair removal methods.

7. Does Trifarotene Cream help with acne scars?

While primarily used for active acne lesions, some studies suggest trifarotene may improve post-inflammatory hyperpigmentation. However, its efficacy on depressed or raised scars is limited.

8. Can I use Trifarotene Cream during the day?

It’s recommended to apply trifarotene in the evening due to potential increased sun sensitivity. If daytime application is necessary, ensure adequate sun protection.