Metformin 500mg & 1000mg: Prices & Benefits

Metformin Tablets are a widely used drug for the treatment of type 2 diabetes. The medication is available in two different strengths, 500mg, and 1000mg, and acts by enhancing the sensitivity of the body to insulin and reducing glucose formation in the liver. Let’s learn about the benefits of Metformin tablets, their usage, price information, harmful effects, and safety aspects with proper handling instructions. The information will be more relevant to individuals who are making inquiries such as “Metformin 500 mg price” and more.

What is Metformin?

Metformin is an orally administered antihyperglycemic agent of the biguanide class, primarily used to treat type 2 diabetes. Such diseases are characterized by failure to make enough insulin or insufficient action of the insulin one produces. The main mechanisms of action of metformin are reduction in hepatic glucose production, improved insulin sensitivity, and improved uptake of glucose by the cells of muscle.

An excellent quality of metformin is its ability to achieve marked diminution in blood sugar without causing a noticeable gain in weight, unlike several other medicines for diabetes, which leads to undesirable effects, like weight gain. Except for its core purpose in treating diabetes, this medicine has also been established in the management of many conditions, thereby making it very versatile in modern medical applications.

Metformin Concentration

Metformin is offered as a tablet, and available strengths include the following:

• 500 mg Tablets: Each tablet will contain 500 mg of metformin hydrochloride, which is responsible for regulating blood sugar concentrations..
• 1000 mg Tablets: Each tablet will consist of 1000 mg of metformin hydrochloride, which yields a higher dose for any patient that needs more considerable control of blood glucose concentration.

Active substances are usually mixed with such inert ingredients as magnesium stearate, povidone, and hypromellose both functioning as binders, stabilizers, or fillers so the pharmacological action doesn’t depend on them at all.

Storage for Metformin

To keep the medicine safe and effective, proper storage is required by metformin. Here is the manufacturer’s storage guideline:

• Temperature: The ideal storage for metformin would be at room temperature within the range of 20°C to 25°C or 68°F to 77°F. Even short periods of exposure at 15°C to 30°C or 59°F to 86°F are acceptable, though extensive exposure to high temperatures degrades the medication, hence lowering its effectiveness.
• Light Protection: The tablet should be stored in the original container, usually a light-resistant bottle, to protect the medicine from light. Light causes chemical breakdown, which can decrease the drug’s potency.
• Protection against Moisture: The tablets must be stored such that they are kept aloof from moisture and humidity. It may disintegrate or lose effectiveness. A cap is to be kept tight and not placed in the bathroom.
• Childproofing: Any medication is to be placed out of the reach of children. Inadvertent ingestion of metformin by a child may prove to be fatal in many cases, particularly hypoglycemia or lactic acidosis.
• Expiry Date: All medications are to be consumed before their expiry date. Metformin is also no exception because the efficacy of such a medication after its expiry date is unknown. It can cause improper working of that drug inside the body, and the health of the patient may also be harmed.

Uses of Metformin

Although Metformin is fundamentally used for type 2 diabetes, it has several more applications:

1. The management of Type 2 Diabetes: Metformin is the first-line medicine for type 2 diabetes treatment. It helps maintain control over glycemic levels which is important in averting complications that are the result of high blood sugar concentrations.
2. Weight Loss: It is usually prescribed as an off-label drug for people who have insulin resistance or obese patients because they lose some weight by Metformin. In a patient taking Metformin, they may develop a reduction of appetite and shift of the body fats.
3. Polycystic Ovary Syndrome (PCOS): Those who are diagnosed with PCOS type of hormonal imbalance that leads to irregular menstruation along with the symptom of insulin resistance can use Metformin. They get proper menses by reducing it; apart from this, their condition improves because it favors normal ovulation.
4. Prevention of Diabetes: Metformin is being used in patients at high risk of developing the disease, delaying its progression by improving insulin sensitivity as well as controlling body weight.
5. Cardio Protection: Metformin prevents cardiovascular diseases in the general population of diabetes.
6. Other Conditions: Emerging research has great promise for Metformin in the treatment of non-alcoholic fatty liver disease, some cancers, and even aging.

How Does Metformin Work?

The various ways metformin works to regulate blood sugar levels are as follows:

• Reduces Glucose Production: Its action is mainly on the liver where it decreases hepatic glucose production, especially during fasting. It inhibits gluconeogenesis, which lowers the level of blood glucose.
• Increases Sensitivity of the Body towards Insulin: The medicine increases the sensitivity of the body to insulin, improving the glucose uptake in muscles and fat cells. Thus, this reduces the glucose levels in the blood and also improves metabolic activities.
• Slows Glucose Absorption: It slows glucose absorption from the intestines and reduces the peaks in the blood glucose after meals.
• Enhances glucose utilization by muscle cells: It enhances the action of insulin in peripheral tissues, which enables muscle cells to use glucose and reduce blood sugar.
• Gut Microbiota: The most recent studies suggest that Metformin can alter gut microbiota composition, and this may also be involved in glucose metabolism and sensitivity to insulin.

Who Can Benefit from Metformin?

Metformin is indicated for adults and children aged 10 years or older with type 2 diabetes. It may also be useful for patients who have:

• Obesity and Insulin Resistance: Such patients may benefit from Metformin as it will help in glycemic control and weight reduction.
• PCOS: Women with PCOS, who are usually present with insulin resistance and have anovulatory cycles, will most likely benefit significantly from the therapy of Metformin since it may restore ovulation and regulate menstrual cycles.
• Prediabetes: A patient having prediabetes is someone whose blood sugar is already high, and he takes Metformin as preventive medication to delay the onset of type 2 diabetes.
• Elderly patients: The patient suffers from type 2 diabetes; hence, metformin may be administered since it has a probable impact on the regulation of sugar without any adverse cardiovascular complication such as that presented by the use of other medications for diabetic conditions.

The Different Dosages of Metformin: 500mg and 1000mg Tablets

Metformin is available in different doses, but 500mg and 1000mg remain the most frequently used doses. These vary to assist in tailoring treatment plans for each individual:

Metformin 500mg Tablets

• Induction Dose: The 500mg induction dose is prescribed as the first dose to newly diagnosed type 2 diabetes patients or those whose symptoms have not reached alarming levels.
• Combination Therapy: Metformin 500mg is widely used in combination with other drugs to efficiently control glucose levels in the blood.
• Titration: Dosing can be titrated upwards depending on the tolerance as well as the control over the blood sugar of the patient.

Metformin 1000mg Tablets

• Higher Dose: The 1000mg tablets are primarily required for patients with significant levels of insulin resistance or by patients whose blood glucose may not be controlled at this dose.
• Extended-Release Preparation: There are many formulations designed as extended-release preparation, thereby allowing once-a-day dosing and might therefore minimize gastrointestinal adverse events associated with this medication.

The dosage of 500mg and 1000mg depends on the condition of the patient and the doctor’s prescription according to the response to the treatment.

How to Take Metformin: Dosage and Administration

For an appropriate effect, it should be taken appropriately. This is with general directives on dosage and administration.

1. The Prescribed Instructions of Your Doctor Ought to be Adhered to: Take strictly the prescriptions given by your doctor when you take Metformin. Dosage may alter depending on the needs of the person.
2. With Food: To compensate for some of the gastrointestinal adverse effects brought by Metformin, it should be taken with food. The rise and fall in sugar levels will also be maintained.
3. Time: Try to take it at consistent times so the blood sugar level does not fluctuate. You may set reminders to remind you not to miss your dosing time.
4. Missed Doses: If you missed a dose, then take it right away if you remember to take one. However, if your next dose is approaching, do not take it and resume your usual schedule. You must not take two at a time.
5. Monitoring Blood Sugar: Monitor blood sugar levels as prescribed by your doctor. You will be able to see the progress of treatment if you record all your measurements, and you will make necessary changes in time.

Benefits of Metformin Tablets

Metformin has many benefits for people with type 2 diabetes and its comorbidities, including:

1. Effective Glucose Level Control: Metformin can lower blood glucose levels effectively. It forms the cornerstone of treatment for patients with type 2 diabetes and generally is the first drug to be started.
2. Weight Loss Support: Not many other diabetes medications help support weight loss or the maintenance of weight; a Metformin is normally linked with weight loss, even though the drug generally induces a decrease in appetite, which can also work as a good facilitator to the overall weight loss in a patient.
3. Cardiovascular Protection: Studies from various research have proved that Metformin lowers diseases in the cardiovascular category for patients with diabetes. According to this, it was also seen that heart attacks and strokes were reduced in patients taking this drug. Hence it is a crucial medicine to be prescribed for people with diabetes.
4. Improves Insulin Sensitivity: Metformin is an insulin sensitizer that improves the functioning of insulin thereby enhancing the metabolic metabolism for better results of overall health.
5. Available in a range of strengths: 500 mg and 1000 mg, hence an appropriate dosing change for the needs of the patients.
6. Lower risk of hypoglycemia: Metformin is not associated with causing hypoglycemia when used as monotherapy.
7. Reduced risks for some specific cancers: Some research shows reduced risk for specific cancers like breast and colorectal associated with Metformin administration, but further studies are necessary in this regard.

Buying Metformin: Prices and Where to Order

The price of Metformin 500 mg varies; it might depend on the pharmacy, place, and kind of insurance coverage. This is only a general guide to what you might expect to pay:

Cost

Metformin 500mg Tablets $15.

1. Metformin 1000mg Tablets: This could go as low as $15 to $30 for the same supply. Extended-release types may be a bit pricier.
2. Glucophage: Glucophage is the brand name for Metformin. Glucophage 500mg and 1000mg will be a bit more in line with the price of generic Metformin, but it might be a bit more expensive due to the brand name.

How to Get It

1. Local Pharmacies: Metformin is in the stock of most pharmacies so you should be able to get one from your local pharmacist and ask to check the price.
2. Online Pharmacies: Many legitimate online pharmacies, including Okdermo, sell Metformin at relatively low prices. Okdermo specializes in dermatological and medical products. So, this pharmacy would be a very convenient place to purchase both your skincare products and your diabetes drugs. However, you need to make sure that the pharmacy you choose is reputable and requires a prescription for Metformin.
3. Discount Programs: Some pharmacies offer discount programs or savings cards that may lower your out-of-pocket costs for your medications.
4. Patient Assistance Programs: If you do not have insurance or have bad insurance, search for patient assistance programs offered by pharmaceutical companies or non-profit organizations.

Ordering from Okdermo

Okdermo is an online pharmacy that offers a wide range of medical and dermatological products, including Metformin. Ordering from Okdermo can be a convenient option for those looking to manage their diabetes and skincare needs simultaneously. Here are some key points to consider:

• Prescription Requirements: Ensure you have a valid prescription for Metformin, as it is a prescription medication. Okdermo may not require a prescription for purchase.
• Customer Service: Okdermo provides support for customers inquiring about their orders, product information, and more, ensuring a smooth shopping experience.
• Discreet Shipping: Okdermo typically offers discreet shipping options for medications, maintaining privacy and confidentiality.

Important Safety Information: Before You Start Taking Metformin

Before using Metformin, you must inform your doctor of all the conditions you have and the drugs you are on. Some important safety considerations include:

• Kidney Function: Metformin is primarily excreted by the kidneys. Patients with impaired kidney function should be used with caution because Metformin increases the risk of lactic acidosis, a rare but serious side effect.
• Liver Condition: Patients suffering from liver diseases should be careful about their medication of Metformin since liver disorders will disturb glucose metabolism.
• Cardiac Problems: Patients having a history of cardiac failure or any other problem in the heart should take the medication Metformin from the physician as in some conditions this medicine might not work properly.
• Alcohol Consumption: Higher alcohol consumption will increase the risk of lactic acidosis. Patients on this drug should either abstain or reduce their alcohol intake.
• Contrast Imaging Tests: If you are going to receive a procedure with contrast dye, you have to advise your doctor regarding this matter. You must temporarily withhold metformin from use before and after the test to avoid risks of kidney damage.

Potential Side Effects of Metformin

Though generally well tolerated, side effects may occur. Common side effects are the following:

1. Gastrointestinal Issues: Nausea and diarrhea, stomach pain, decreased appetite, particularly in the first few months. Most people improve with time to tolerate it much better.
2. Lactic acidosis: Though uncommon, lactic acidosis can occur with the use of Metformin, mainly in patients with renal insufficiency. Symptoms are typically weakness, fatigue, muscle pain, shortness of breath, and a sense of impending doom.
3. Vitamin B12 deficiency: Metformin therapy should be maintained for a more extended period, with impaired absorption of Vitamin B12. It is recommended that the patients be monitored regularly for vitamin B12 levels.
4. Dermatologic Reactions: Some patients experience skin rashes or allergic reactions. If you have any type of skin changes, you should see your healthcare provider.
5. Hypoglycemia: Hypoglycemia is rare with the use of Metformin alone. However, if other diabetes drugs are prescribed in addition to Metformin, the patient may suffer from hypoglycemia. The patient needs to be conscious of his blood sugar levels and the symptoms of hypoglycemia.

Limitations for Metformin

Despite this strong efficacy in the control of type 2 diabetes, limitations exist and are very noteworthy. These include risks, which represent potential side effects of a drug, contraindications, limits on a drug’s efficacy in effectiveness, and drug-to-drug interactions.

1. Side-Effects

Metformin has side effects, but toleration is excellent. Even upon initiation or when escalating to a higher dose side effects may be observed for:

• Gastrointestinal Disturbances: Gastrointestinal disturbances (nausea, diarrhea, abdominal pain, and flatulence) are the most common adverse effects of metformin. However, most patients tend to recover from these effects over time. Extended-release formulations of metformin (e.g., metformin XR) can be used in attempts to minimize GI side effects.
• Vitamin B12 deficiency: Long-term therapy with metformin leads to vitamin B12 malabsorption, which sometimes may even lead to a deficiency state in some patients. Clinical manifestations of the deficiency can include fatigue, weakness, and numbness or paresthesias of hands and feet. The importance of monitoring the level of vitamin B12 during treatment with long-term metformin therapy should not be overlooked.
• Lactic acidosis: even though it is a rather rare condition, metformin increases the amount of this chemical in the blood. It is dangerous for an individual because of health conditions that may tend toward kidney disorders, liver failures, failure of heart failure, and excessive consumption of alcohol. Some symptoms under this category include muscle aches, respiratory distress, dizziness, and stomach pains, where medical aid must be sought right away.

2. Efficacy Limitations

While metformin is effective in regulating blood sugar, it carries efficacy limits in that

Its postprandial glucose-elevating effect is modest compared with other antidiabetic drugs. Therefore, in patients who require tight control of postprandial glucose, such drugs as sulfonylureas, meglitinides, or insulin would be added to this treatment regimen.

• Non-Insulin-Dependent Patients: The drug is most effective in patients who still produce insulin but are suffering from a resistance of the hormone, type 2 diabetes. It is not usually effective for patients who have type 1 diabetes or those who have a total loss of insulin production.
• Weight Loss: Metformin causes small weight losses for some, but this drug is not considered a weight-loss medication. Since its modest weight-neutral or modestly weight-reducing effects create lesser desirability when it’s necessary for more sizeable weight reductions to also accompany diabetes therapy.

3. Contraindications

Metformin has relative contraindications within certain patients because its severe side effect risk will increase or is less effective with the patient. Examples include the following:

• Kidney Failure: Metformin is excreted via the kidneys, and the use of metformin in patients with severe kidney failure (eGFR less than 30 mL/min/1.73 m²) places them at risk for lactic acidosis. Thus, metformin should not be administered in severe kidney failure. For those whose kidney impairment falls within the mild to moderate range, that is, eGFR between 30 and 60 mL/min/1.73 m², adjustments can be made.
• Liver Disease: Metformin should be avoided for severe liver disease because the level of risk for lactic acidosis is increased in such cases. The principal organ for lactate metabolization is the liver; hence, a dysfunction will increase the concentration of blood lactate.
• Heart Failure: Patients with unstable or acute heart failure should also be treated cautiously or not be given metformin because such conditions predispose them to lactic acidosis.
• Excessive Alcohol Consumption: Alcohol can make the risk of lactic acidosis higher in the patient, especially if taking metformin. The patient should avoid excessive alcohol intake during this treatment.

Frequently Asked Questions (FAQs)

What is Metformin used for?

Metformin is primarily used to manage type 2 diabetes, helping to control blood sugar levels and improve insulin sensitivity. It is also used for conditions such as PCOS and obesity.

How much do Metformin 500mg and 1000mg cost?

The price varies; Metformin 500mg typically ranges from $4 to $20, while 1000mg costs between $10 and $30 for a 30-day supply.

What are the differences between Metformin 500mg and 1000mg?

The main difference is the dosage strength; 500mg is often used as a starting dose, while 1000mg may be prescribed for more severe cases or those needing additional glucose control.

How should I take Metformin safely?

Take as prescribed, with food, and do not skip doses. Follow your healthcare provider’s instructions closely.

What are the potential side effects of Metformin?

Common side effects include nausea, diarrhea, and stomach pain. Severe side effects, such as lactic acidosis, are rare but may require immediate medical attention.

Can Metformin be taken with other medications?

Yes, Metformin is often used in combination with other diabetes medications. However, it’s crucial to discuss all medications with your healthcare provider to avoid potential interactions.

Is Metformin safe during pregnancy?

Metformin is generally considered safe during pregnancy, particularly for women with PCOS or diabetes. However, always consult with your healthcare provider before starting or continuing medication during pregnancy.

Can Metformin cause weight loss?

Yes, Metformin is often associated with weight loss or stabilization, making it a preferred choice for individuals with insulin resistance and obesity.

How often should I monitor my blood sugar levels while taking Metformin?

Follow your healthcare provider’s recommendations for monitoring your blood sugar levels, typically at least once a day or more frequently if your medication regimen changes.

What should I do if I miss a dose of Metformin?

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Conclusion

Metformin 500mg and 1000mg tablets are also one of the best products available for the treatment of type 2 diabetes because both dosages serve for a flexible treatment with competitive Metformin 500 mg price and extensive benefits. It is thus the core medication for every person looking to regulate the levels of blood sugar within his or her body, though the drug has immense efficacy in the treatment of diabetes and also holds additional advantages of weight loss management and heart health.

Before starting Metformin, the patient should seek consultations from the physician to be sure of the right dosage and possible risks or adverse effects. Adherence to drugs, lifestyle changes, and monitoring of blood glucose are all essential elements in the management of diabetes. Further research is discovering increasingly broader applications of Metformin, but this alone already has a substantial role in diabetes and other challenges in health.

References

1. Pernicova, I., & Márta Korbonits. (2014). Metformin—mode of action and clinical implications for diabetes and cancer. Nature Reviews Endocrinology, 10(3), 143–156. https://doi.org/10.1038/nrendo.2013.256
2. Hameed. (2017). Dose Comparison And Side Effect Profile Of Metformin Extended Release Versus Metformin Immediate Release. Journal of Ayub Medical College, Abbottabad : JAMC, 29(2). https://pubmed.ncbi.nlm.nih.gov/28718236/
3. Ziquan Lv, & Guo, Y. (2020). Metformin and Its Benefits for Various Diseases. Frontiers in Endocrinology, 11. https://doi.org/10.3389/fendo.2020.00191
4. Scheen, A. J. (1996). Clinical Pharmacokinetics of Metformin. Clinical Pharmacokinetics, 30(5), 359–371. https://doi.org/10.2165/00003088-199630050-00003

Post by:

 Dr.Marcella Jiovanni

Health and Beauty Expert

“Marcella Jiovanni actively promotes the importance of maintaining healthy skin, she envisions the future of dermatology as moving away from pure medical, pharmacological dermatology and flowing more toward a holistic approach to wellness and skincare.”