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Efficacy and Safety of Topical Clascoterone Cream

Recent Studies have evaluated the effectiveness and safety of a potential new therapy for acne. It is known as Topical Clascoterone Cream. Clascoterone is an artificial androgen receptor antagonist. It reduces sebum production. It is a critical factor in the development of acne. Clascoterone cream affects the hormone that causes acne. The most recent studies on the effectiveness and safety of topical Clascoterone cream for treating acne will be evaluated in this article. Its potential as a novel and creative method of managing acne will also be discussed.

Benefits Of Clascoterone Cream:

Topical Clascoterone cream is a relatively new medication. It comes with great promise in treating acne. We will explore the benefits of clascoterone cream for treating acne:

1. High Efficacy:

Clascoterone cream’s strong effectiveness in treating acne is one of its main advantages. Clascoterone cream significantly reduced the severity of acne in 1445 individuals. They had moderate to severe facial acne compared to the control group. The Facial Acne Severity Index (FASI) score exhibited a mean decrease of 18.5 in the clascoterone group at week 12 compared to 13.8 in the control group (P 0.001). Clascoterone cream is a successful alternative for treating moderate to severe acne.

2. Targeted Hormonal Therapy:

Clascoterone cream focuses on the underlying hormonal causes of acne. Hormonal imbalances significantly higher levels of androgens like testosterone. These are often linked to acne. It reduces excess sebum production. It selectively suppresses the activity of androgens in the sebaceous glands. Clascoterone cream reduces sebum production. So, it reduces acne. This customized hormone therapy is brand-new. It is a cutting-edge method of treating acne.

3. Safe for Long-Term Use:

Clascoterone cream’s superior safety profile is another significant advantage. It is used especially for long-term usage. Clascoterone cream was well tolerated in a 52-week safety trial. It included 1378 individuals with moderate to severe facial acne. They had a low incidence of adverse effects. There was no significant adverse effect. The most frequent adverse effect were erythema at the application site and pruritus. These findings imply that the long-term use of clascoterone cream for treating acne is secure.

4. Minimal Systemic Absorption:

Additionally, the low systemic absorption of clascoterone cream lowers the possibility of systemic side effects. Topical clascoterone cream had a negligible impact on the levels of cortisol, luteinizing hormone, follicle-stimulating hormone, and testosterone in research involving 24 healthy male volunteers. These results imply that even long-term usage of clascoterone cream is unlikely to result in systemic adverse effects.

Dosing Of Clascoterone Cream:

The suggested dosage is a thin coating of topical clascoterone cream twice a day. Apply it in the morning and evening. Gently massage it into the skin. Ensure the safe and efficient use of clascoterone cream. It is crucial to adhere to the dose recommendations given by your healthcare professional. Read those listed on the drug package. Consult your healthcare provider for more information. Discuss questions or concerns about how much clascoterone cream to apply.

How To Use Clascoterone Cream:

Use topical clascoterone cream by the following method:

  • Clean your skin with a cleanser. Pat it dry.
  • The cheeks, forehead, and other affected facial areas should be covered. Apply a thin coating of topical clascoterone cream.
  • Completely absorb the cream. Massage it gently to the skin.
  • Wash your hands.
  • Clascoterone cream should be used in the morning and night. Use as per what your doctor prescribes.
  • Clascoterone cream should be used as instructed. Excessive usage should be avoided. If you use too much cream, you can experience side effects, including dryness or skin irritability.
  • Additionally, you should avoid using the cream on broken or irritated skin. Contact your healthcare provider immediately.


Some precautions must be taken before using topical clascoterone cream. Keep the followings in your mind:

  • Avoid getting topical clascoterone cream in your eyes, lips, or mucous membranes. It is only for external use. If you unintentionally get cream in your eyes, wash them with water. And, Call your doctor.
  • Avoid exposure to sunlight and UV rays. Topical Clascoterone cream may make your skin more sensitive to them. Therefore, wear protective clothing. Use sunscreen to protect your skin.
  • Clascoterone cream must not be used on irritated, infected, or broken skin. Before applying clascoterone cream, allow open sores or skin infections to heal completely.
  • Before using clascoterone cream, you should let your doctor know if you have any allergies to any of the ingredients.
  • If you are expecting or nursing, speak with your doctor. It is crucial to talk with your doctor before taking clascoterone cream if you are pregnant or nursing. It is crucial because its safety has not been determined during these times.
  • Clascoterone cream should only be used as your doctor prescribes or as detailed on the drug’s label.


  • “Efficacy And Safety Of Topical Clascoterone Cream, 1%, For Treatment In Patients With Facial Acne: Two Phases 3 Randomized Clinical Trials.”. Retrieved from
  • Shrooq Tail. “Efficacy And Safety Of Topical Clascoterone Cream For The Treatment Of Acne Vulgaris: A Systematic Review And Meta‐Analysis Of Randomized Placebo‐Controlled Trials.” Retrieved from
  • “Androgens And Acne: Perspectives On Clascoterone, The First Topical Androgen Receptor Antagonist.” Retrieved from
  • “Open-Label, Long-Term Extension Study To Evaluate The Safety Of Clascoterone (CB-03-01) Cream, 1% Twice Daily, In Patients With Acne Vulgaris.”Retrieved from
  • Y. “Clascoterone As A Novel Treatment For Androgenetic Alopecia.”Retrieved from

Post by:

Dermatologist Marcela J






Marcella Jiovanni

Skin Care Professional

“Marcella Jiovanni actively promotes the importance of maintaining healthy skin, she envisions the future of dermatology as moving away from pure medical, pharmacological dermatology and flowing more toward a holistic approach to wellness and skincare.”